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「a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/09/03 06:38:53」(JST)

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  • Sulfonamides: a patent review (2008 - 2012).
  • Carta F, Scozzafava A, Supuran CT.SourceUniversità degli Studi di Firenze, Laboratorio di Chimica Bioinorganica , Rm. 188, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Florence) , Italy +39 0554573273 ; +39 055 4573385 ;
  • Expert opinion on therapeutic patents.Expert Opin Ther Pat.2012 Jul;22(7):747-58. Epub 2012 Jun 15.
  • Introduction: The primary sulfonamide moiety is present in many clinically used drugs, such as diuretics (furosemide, indapamide, chlorthalidone, thiazides); carbonic anhydrase (CA) inhibitors (CAIs) (including acetazolamide, dichlorophenamide, dorzolamide and brinzolamide); antiepileptics (zonisam
  • PMID 22697257
  • Nonsteroidal anti-inflammatory drug-activated gene-1 plays a role in the impairing effects of cyclooxygenase inhibitors on gastric ulcer healing.
  • Colucci R, Antonioli L, Bernardini N, Ippolito C, Segnani C, Awwad O, Tuccori M, Blandizzi C, Scarpignato C, Fornai M.SourceInterdepartmental Centre for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, Via Roma 55, 56126, Pisa, Italy.
  • The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2012 Jul;342(1):140-9. Epub 2012 Apr 10.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) can impair gastric ulcer healing. This study investigates the involvement of NSAID-activated gene-1 (NAG-1) in ulcer repair impairment by cyclooxygenase (COX) inhibitors. Gastric ulcers were induced in rats by acetic acid. Four days later, animals receiv
  • PMID 22495067


  • 酸化的芳香化の制御を機軸とするヨード環化反応の開発
  • 沖津 貴志
  • YAKUGAKU ZASSHI 131(9), 1323-1327, 2011
  • … The utility of our methodology was demonstrated in the synthesis of valdecoxib and its 2,5-dihydro analogs. …
  • NAID 130001871938
  • Preparation, Characterization and in Vitro Dissolution Studies of Solid Systems of Valdecoxib with Chitosan
  • Vijaya Kumar Sengodan Gurusamy,Mishra Dina Nath
  • Chemical & pharmaceutical bulletin 54(8), 1102-1106, 2006-08-01
  • … In the present study, the solubilizing and amorphizing properties of Valdecoxib (a poorly water soluble anti inflammatory drug) with low molecular weight chitosan (a polymer), have been investigated. … Enhanced dissolution combined with its direct compression feasibility and anti ulcerogenic action results in low molecular weight chitosan for developing fast release oral solid dosage forms of valdecoxib. …
  • NAID 110004847226
  • Spray Dried Excipient Base : A Novel Technique for the Formulation of Orally Disintegrating Tablets
  • Mishra Dina Nath,Bindal Madhu,Singh Shailendra Kumar [他],VIJAYA KUMAR Sengodan Gurusamy
  • Chemical & pharmaceutical bulletin 54(1), 99-102, 2006-01-01
  • … The purpose of this study is to assess the suitability of spray dried excipient base in the formulation of ODTs of Valdecoxib (low aqueous solubility) and Metoclopramide (high aqueous solubility). …
  • NAID 110004820332


Valdecoxibとは?goo Wikipedia (ウィキペディア) 。出典:Wikipedia(ウィキペディア)フリー百科事典。 Valdecoxibとは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ヘルプ メニューへスキップ 本文へ ...
Buy Valdecoxib (CAS 181695-72-7), a selective inhibitor of Cox-2, from Santa Cruz. Purity ≥98%, Molecular Formula C16H14N2O3S, Molecular Weight 314.36 ... Valdecoxib is a prescription NSAID exhibiting anti-inflammatory ...


Fazem mal para o coraçãoThe Bextra -- (Valdecoxib) Molecule..Valdecoxib drug moleculeDescription Valdecoxib-from-xtal-3D-balls Valdecoxib has the following structural Valdecoxib is a non-steroidal anti