vacuolar H+-ATPase

出典: meddic

V-ATPaseV-type ATPasevacuolar ATPasevacuolar proton-translocating ATPase

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  • RAF265, a dual BRAF and VEGFR2 inhibitor, prevents osteoclast formation and resorption. Therapeutic implications.
  • Garcia-Gomez A, Ocio EM, Pandiella A, San Miguel JF, Garayoa M.SourceCentro de Investigación del Cáncer, IBMCC (Universidad de Salamanca-CSIC), Campus Miguel de Unamuno, Avda. Coimbra s/n, 37007, Salamanca, Spain.
  • Investigational new drugs.Invest New Drugs.2013 Feb;31(1):200-5. doi: 10.1007/s10637-012-9845-3. Epub 2012 Jul 7.
  • Introduction The RAS/RAF/MEK/ERK signaling pathway plays an important role in osteoclast (OC) differentiation and survival mediated by macrophage-colony stimulating factor (M-CSF). Also, vascular endothelial growth factor (VEGF) may greatly influence OC formation and resorption through VEGFR1 and VE
  • PMID 22773056
  • SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts.
  • Coury F, Zenger S, Stewart AK, Stephens S, Neff L, Tsang K, Shull GE, Alper SL, Baron R, Aliprantis AO.SourceDepartment of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115.
  • Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2013 Jan 22. [Epub ahead of print]
  • Bone remodeling requires osteoclasts to generate and maintain an acidified resorption compartment between the apical membrane and the bone surface to solubilize hydroxyapatite crystals within the bone matrix. This acidification process requires (i) apical proton secretion by a vacuolar H(+)-ATPase,
  • PMID 23341620
  • Activation of the proton pump, V-ATPase, triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium.
  • Petzoldt AG, Gleixner EM, Fumagalli A, Vaccari T, Simons M.SourceFreie Universität, Berlin, Germany;
  • Disease models & mechanisms.Dis Model Mech.2013 Jan 18. [Epub ahead of print]
  • The C subunit of the vacuolar H(+)-ATPase or V-ATPase regulates the activity and assembly of the proton pump at cellular membranes. It has been shown to be strongly upregulated in oral squamous cell carcinoma, a highly metastatic epithelial cancer. In addition, increased V-ATPase activity appears to
  • PMID 23335205


  • Increased production of reactive oxygen species by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A in RAW 264 cells
  • YOKOMAKURA Aya,HONG JangJa,OHUCHI Kazuo,OH Seong-Eun,LEE Jin-Yong,MANO Nariyasu,TAKAHASHI Tsutomu,HWANG Gi-Wook,NAGANUMA Akira
  • Journal of toxicological sciences 37(5), 1045-1048, 2012-10-01
  • NAID 10030876740
  • Increased production of reactive oxygen species by the vacuolar-type (H)-ATPase inhibitors bafilomycin A1 and concanamycin A in RAW 264 cells
  • Yokomakura Aya,Hong JangJa,Ohuchi Kazuo
  • The Journal of toxicological sciences 37(5), 1045-1048, 2012-10
  • NAID 40019458234


1. Physiol Rev. 2004 Oct;84(4):1263-314. Renal vacuolar H+-ATPase. Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP. Institute of Physiology, Univ. of Zurich, Winterthurerstrasse 190, CH-8057 Zurich ...
73 REVIEW (Pro)renin Receptor and Vacuolar H+−ATPase Atsuhiro Ichihara Department of Medicine II, Endocrinology and Hypertension, Tokyo Women’s Medical University, Tokyo, Japan (Received for publication on August 9, 2011)


Original file ‎ (Ogg Theora video file AtpaseATPaseATPase, see Proton ATPase .FIG. 2.Vacuolar-type H + -ATPase ( V-ATPase ) is

先読みV-ATPase」「vacuolar proton-translocating ATPase」「vacuolar ATPase」「V-type ATPase」「液胞型プロトンATPase



V-type ATPasevacuolar ATPasevacuolar H+-ATPasevacuolar proton-translocating ATPase

vacuolar proton-translocating ATPase」


V-ATPaseV-type ATPasevacuolar ATPasevacuolar H+-ATPase

vacuolar ATPase」



V-ATPaseV-type ATPasevacuolar H+-ATPasevacuolar proton-translocating ATPase

V-type ATPase」


V-ATPasevacuolar ATPasevacuolar H+-ATPasevacuolar proton-translocating ATPase



vacuolar H+-ATPase



WordNet   license wordnet

「the 8th letter of the Roman alphabet」

PrepTutorEJDIC   license prepejdic


PrepTutorEJDIC   license prepejdic

「鉛筆の硬度 / 《俗》heroin」



  • adj.
  • 空胞の、空胞性の、液胞の



ATP hydrolase