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1. トラスツズマブおよびその他の抗HER2薬の心毒性 cardiotoxicity of trastuzumab and other her2 targeted agents
2. 血管新生阻害剤の概要 overview of angiogenesis inhibitors

Amplicon rearrangements during the extrachromosomal and intrachromosomal amplification process in a glioma.

Vogt N1, Gibaud A2, Lemoine F3, de la Grange P3, Debatisse M2, Malfoy B2.
Nucleic acids research.Nucleic Acids Res.2014 Dec 1;42(21):13194-205. doi: 10.1093/nar/gku1101. Epub 2014 Nov 6.
The mechanisms of gene amplification in tumour cells are poorly understood and the relationship between extrachromosomal DNA molecules, named double minutes (dmins), and intrachromosomal homogeneously staining regions (hsr) is not documented at nucleotide resolution. Using fluorescent in situ hybrid
PMID 25378339

Noninvasive saliva-based EGFR gene mutation detection in patients with lung cancer.

Wei F1, Lin CC, Joon A, Feng Z, Troche G, Lira ME, Chia D, Mao M, Ho CL, Su WC, Wong DT.
American journal of respiratory and critical care medicine.Am J Respir Crit Care Med.2014 Nov 15;190(10):1117-26. doi: 10.1164/rccm.201406-1003OC.
RATIONALE: Constitutive activation of the epidermal growth factor receptor (EGFR) is prevalent in epithelial cancers, particularly in non-small cell lung carcinoma (NSCLC). Mutations identified in EGFR predict the sensitivity to EGFR-targeted therapy. Detection of these mutations is mainly based on
PMID 25317990

ALK rearrangement in a large series of consecutive non-small cell lung cancers: comparison between a new immunohistochemical approach and fluorescence in situ hybridization for the screening of patients eligible for crizotinib treatment.

Alì G1, Proietti A, Pelliccioni S, Niccoli C, Lupi C, Sensi E, Giannini R, Borrelli N, Menghi M, Chella A, Ribechini A, Cappuzzo F, Melfi F, Lucchi M, Mussi A, Fontanini G.
Archives of pathology & laboratory medicine.Arch Pathol Lab Med.2014 Nov;138(11):1449-58. doi: 10.5858/arpa.2013-0388-OA. Epub 2014 Jun 2.
CONTEXT: Echinoderm microtubule associated proteinlike 4-anaplastic lymphoma receptor tyrosine kinase (EML4-ALK) translocation has been described in a subset of patients with non-small cell lung cancer (NSCLC) and has been shown to have oncogenic activity. Fluorescence in situ hybridization (FISH) i
PMID 24885803