WordNet

occurring or encountered or experienced or observed frequently or in accordance with regular practice or procedure; "grew the usual vegetables"; "the usual summer heat"; "came at the usual time"; "the childs usual bedtime"
of or relating to interstices
respiratory disease characterized by inflammation of the lung parenchyma (excluding the bronchi) with congestion caused by viruses or bacteria or irritants

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『いつもの』,通例の,おきまりの
肺炎

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/26 06:42:54」(JST)

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Usual interstitial pneumonia (UIP) is a form of lung disease characterized by progressive scarring of both lungs.^[1] The scarring (fibrosis) involves the supporting framework (interstitium) of the lung. UIP is thus classified as a form of interstitial lung disease. The term "usual" refers to the fact that UIP is the most common form of interstitial fibrosis. "Pneumonia" indicates "lung abnormality", which includes fibrosis and inflammation. The term used for UIP in the British literature is cryptogenic fibrosing alveolitis, a term that has fallen out of favor since the basic underlying pathology is now thought to be fibrosis, not inflammation.

Causes

The cause of the scarring in UIP may be known (less commonly) or unknown (more commonly). Since the medical term for conditions of unknown cause is "idiopathic", the clinical term for UIP of unknown cause is idiopathic pulmonary fibrosis (IPF). Examples of known causes of UIP include systemic sclerosis/scleroderma, rheumatoid arthritis, asbestosis and chronic nitrofurantoin toxicity.

Symptoms

The typical symptoms of UIP are progressive shortness of breath and cough for a period of months. In some patients, UIP is diagnosed only when a more acute disease supervenes and brings the patient to medical attention.

Diagnosis

UIP may be diagnosed by a radiologist using a computed tomogram of the chest (CT scan of the chest), or by a pathologist using tissue obtained by a lung biopsy. Radiologically, the main feature required for a confident diagnosis of UIP is honeycomb change in the periphery and the lower portions (bases) of the lungs.^[2] The histologic hallmarks of UIP, as seen in lung tissue under a microscope by a pathologist, are interstitial fibrosis in a "patchwork pattern", honeycomb change and fibroblast foci (see images below).^[3]

Pathological findings in usual interstitial pneumonia (UIP)
Appearance of usual interstitial pneumonia (UIP) in a surgical lung biopsy at low magnification. The tissue is stained with hematoxylin (purple dye) and eosin (pink dye) to make it visible. The pink areas in this picture represent lung fibrosis (collagen stains pink). Note the "patchwork" (quilt-like) pattern of the fibrosis.
Appearance of honeycomb change in a surgical lung biopsy at low magnification. The dilated spaces seen here are filled with mucin. Hematoxylin-eosin stain, low magnification.
A fibroblast focus in a surgical lung biopsy of UIP. Hematoxylin-eosin stain, high magnification. The white space to the left is an airspace. The pale area to the right is a fibroblast focus. It is an area of active fibroblast proliferation within the interstitium of the lung.

Differential diagnosis

The differential diagnosis includes other types of lung disease that cause similar symptoms and show similar abnormalities on chest radiographs. Some of these diseases cause fibrosis, scarring or honeycomb change. The most common considerations include:

chronic hypersensitivity pneumonitis
non-specific interstitial pneumonia
sarcoidosis
pulmonary Langerhans cell histiocytosis
asbestosis ^[4]

Prognosis

Regardless of etiology, UIP is relentlessly progressive, usually leading to respiratory failure and death. Some patients do well for a prolonged period of time, but then deteriorate rapidly because of a superimposed acute illness (so-called "accelerated UIP"). The outlook for long-term survival is poor. In most studies, the median survival is 3 to 4 years. Patients with UIP in the setting of rheumatoid arthritis have a slightly better prognosis than UIP without a known cause (IPF).

History

UIP, as a term, first appeared in the pathology literature. It was coined by Averill Abraham Liebow.^[5]

References

^ Travis WD, King TE, Bateman ED, et al. (2002). "ATS/ERS international multidisciplinary consensus classification of idiopathic interstitial pneumonias. General principles and recommendations.". American Journal of Respiratory and Critical Care Medicine 165 (5): 277–304. PMID 11790668.
^ Sumikawa H, et al (2008). "Computed tomography findings in pathological usual interstitial pneumonia: relationship to survival.". American Journal of Respiratory and Critical Care Medicine 177 (4): 433–439. doi:10.1164/rccm.200611-1696OC. PMID 17975197.
^ Katzenstein AL, Mukhopadhyay S, Myers JL (2008). "Diagnosis of usual interstitial pneumonia and distinction from other fibrosing interstitial lung diseases.". Human Pathology 39 (9): 1275–1294. doi:10.1016/j.humpath.2008.05.009. PMID 18706349.
^ Leslie, Kevin O; Wick, Mark R. (2005). Practical pulmonary pathology: a diagnostic approach. Edinburgh: Churchill Livingstone. ISBN 0-443-06631-0. OCLC 156861539.
^ Averill Abraham Liebow at Who Named It?

External links

Coalition for Pulmonary Fibrosis: Pulmonary Fibrosis Patient Services, Education; Funding Research to Find a Cure for PF - coalitionforpf.org.
PA-IPF - The Pennsylvania Idiopathic Pulmonary Fibrosis State Registry at University of Pittsburgh

UpToDate Contents

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1. 特発性間質性肺炎：臨床症状および病理 idiopathic interstitial pneumonias clinical manifestations and pathology
2. 特発性肺線維症の治療 treatment of idiopathic pulmonary fibrosis
3. 間質性肺疾患を有する成人に対するアプローチ：臨床的評価 approach to the adult with interstitial lung disease clinical evaluation
4. 非特異的間質性肺炎 nonspecific interstitial pneumonia
5. 肺の高分解能CT high resolution computed tomography of the lungs

English Journal

Preclinical murine models of Chronic Obstructive Pulmonary Disease.

Vlahos R1, Bozinovski S2.
European journal of pharmacology.Eur J Pharmacol.2015 Jul 15;759:265-71. doi: 10.1016/j.ejphar.2015.03.029. Epub 2015 Mar 24.
Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and is the 4th leading cause of death worldwide. It is believed that an exaggerated inflammatory response to cigarette smoke causes progressive airflow limitation. This inflammation, where macrophages, neutrophils
PMID 25818750

Mixed-effects model of epithelial-mesenchymal transition reveals rewiring of signaling networks.

Desai P1, Yang J2, Tian B3, Sun H2, Kalita M4, Ju H5, Paulucci-Holthauzen A6, Zhao Y7, Brasier AR7, Sadygov RG8.
Cellular signalling.Cell Signal.2015 Jul;27(7):1413-25. doi: 10.1016/j.cellsig.2015.03.024. Epub 2015 Apr 8.
The type II epithelial-mesenchymal transition (EMT) produces airway fibrosis and remodeling, contributing to the severity of asthma and chronic obstructive pulmonary disease. While numerous studies have been done on the mechanisms of the transition itself, few studies have investigated the system ef
PMID 25862520

Anti-profibrotic effects of artesunate on bleomycin-induced pulmonary fibrosis in Sprague Dawley rats.

Wang C1, Xuan X1, Yao W2, Huang G1, Jin J2.
Molecular medicine reports.Mol Med Rep.2015 Jul;12(1):1291-7. doi: 10.3892/mmr.2015.3500. Epub 2015 Mar 17.
The present study aimed to determine whether artesunate has beneficial effects on bleomycin‑induced pulmonary fibrosis in rats and to examine the possible mechanisms underlying these effects. All experiments were performed with male Sprague Dawley rats weighing 180‑250 g. Animals were randomly
PMID 25816117

Japanese Journal

Complication of Chronic Eosinophilic Pneumonia in an Elderly Patient with Sjögren Syndrome

Waseda Koichi,Hagiya Hideharu,Hanayama Yoshihisa,Terasaka Tomohiro,Kimura Kosuke,Tsuzuki Takao,Hasegawa Kou,Nada Takahiro,Nakamura Eri,Murakami Kazutoshi,Kondo Eisei,Otsuka Fumio
Acta Medica Okayama 69(2), 123-127, 2015-04
… Based on the high level of eosinophils observed in his bronchial alveolar lavage, he was diagnosed with chronic eosinophilic pneumonia (CEP) and successfully treated by oral prednisolone. … Interstitial lung diseases associated with pSS (pSS-ILDs) usually present as nonspecific interstitial pneumonia or usual interstitial pneumonia; …
NAID 120005595786

間質性肺炎合併肺癌手術例におけるリスク評価

伊達洋至
呼吸器内科 26(6), 479-483, 2014-12
NAID 40020307643

病理学的な概説と今後の課題 (特集 ATS/ERS 2013 IIPs分類と今後の課題)

寺﨑泰弘,漆山博和,福田悠
日本胸部臨床 73(11), 1295-1306, 2014-11
NAID 40020252543

Related Pictures

★リンクテーブル★

リンク元	「蜂巣肺」「通常型間質性肺炎」
関連記事	「interstitial」「usual」

「蜂巣肺」

Usual Interstitial Pneumonia
	Classification and external resources
	Usual interstitial pneumonia seen on CT scan. Honeycomb fibrosis is seen at the bases of both lungs.
ICD-9	515
DiseasesDB	4815

　　[★]

英: honey-comb lung, honeycomb lung, honey comb lung
同: 蜂窩肺
関: 嚢胞性肺線維症

臨床関連

「通常型間質性肺炎」

　　[★]

英: usual interstitial pneumonia
関: 特発性間質性肺炎、間質性肺炎

「interstitial」

　　[★]

adj.

間質性の、間質内の、侵入型の、組織内の、介在の、介在性の、中間部の、間質の

関: intercalary、intermediate、internuncial、interstitial tissue、interstitium、intervene、intervening、interzonal、invasive、stroma、stromal、stromata

「usual」

　　[★]

adj.

常の、平常の、平素の、普段の、いつもの。通常の、通例の、ありふれた、日常の

n.

(the [one's] ～)いつものこと

関: common、commonly、conventional、general、generally、in general、normal、normally、ordinarily、ordinary、usually

[1] Travis WD, King TE, Bateman ED, et al. (2002). "ATS/ERS international multidisciplinary consensus classification of idiopathic interstitial pneumonias. General principles and recommendations.". American Journal of Respiratory and Critical Care Medicine 165 (5): 277–304. PMID 11790668.

[2] Sumikawa H, et al (2008). "Computed tomography findings in pathological usual interstitial pneumonia: relationship to survival.". American Journal of Respiratory and Critical Care Medicine 177 (4): 433–439. doi:10.1164/rccm.200611-1696OC. PMID 17975197.

[3] Katzenstein AL, Mukhopadhyay S, Myers JL (2008). "Diagnosis of usual interstitial pneumonia and distinction from other fibrosing interstitial lung diseases.". Human Pathology 39 (9): 1275–1294. doi:10.1016/j.humpath.2008.05.009. PMID 18706349.

[leslie-4] Leslie, Kevin O; Wick, Mark R. (2005). Practical pulmonary pathology: a diagnostic approach. Edinburgh: Churchill Livingstone. ISBN 0-443-06631-0. OCLC 156861539.

[5] Averill Abraham Liebow at Who Named It?

匿名

検索

案内

案内

usual interstitial pneumonia