uroguanylin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/03/04 07:33:20」(JST)

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guanylate cyclase activator 2B (uroguanylin)
Identifiers
Symbol	GUCA2B
Entrez	2981
HUGO	4683
OMIM	601271
RefSeq	NM_007102
UniProt	Q16661
Other data
Locus	Chr. 1 p34-p33

Uroguanylin

Identifiers
CAS Registry Number	152175-68-3 Y
ChemSpider	4589972 Y
InChI InChI=1S/C61H101N17O25S4/c1-9-26(6)46(60(101)72-33(17-40(64)81)54(95)76-45(25(4)5)59(100)66-27(7)48(89)73-36(21-105)57(98)78-47(28(8)79)58(99)65-19-41(82)67-38(23-107)61(102)103)77-56(97)37(22-106)75-52(93)32(16-24(2)3)70-51(92)31(12-15-43(85)86)69-55(96)35(20-104)74-53(94)34(18-44(87)88)71-50(91)30(11-14-42(83)84)68-49(90)29(62)10-13-39(63)80/h24-38,45-47,79,104-107H,9-23,62H2,1-8H3,(H2,63,80)(H2,64,81)(H,65,99)(H,66,100)(H,67,82)(H,68,90)(H,69,96)(H,70,92)(H,71,91)(H,72,101)(H,73,89)(H,74,94)(H,75,93)(H,76,95)(H,77,97)(H,78,98)(H,83,84)(H,85,86)(H,87,88)(H,102,103)/t26-,27-,28+,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,45-,46-,47-/m0/s1 Y Key: SJMPVWVIVWEWJK-AXEIBBKLSA-N Y
Jmol-3D images	Image
MeSH	uroguanylin
PubChem	5488765
SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CS)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CS)C(O)=O
Properties
Molecular formula	C61H101N17O25S4
Molar mass	1,600.81 g·mol−1
Related compounds
Related compounds	PMDTA
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Uroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor GC-C and regulates electrolyte and water transport in intestinal and renal epithelia.

In humans, the uroguanylin peptide is encoded by the GUCA2B gene.

See also

• Natriuretic peptide

References

External links

• uroguanylin at the US National Library of Medicine Medical Subject Headings (MeSH)

English Journal

• Uroguanylin action in the brain reduces weight gain in obese mice via different efferent autonomic pathways.

• Folgueira C1, Beiroa D2, Callon A3, Al-Massadi O2, Barja-Fernandez S4, Senra A5, Fernø J6, López M2, Dieguez C2, Casanueva FF7, Rohner-Jeanrenaud F3, Seoane LM8, Nogueiras R9.
• Diabetes.Diabetes.2015 Nov 13. pii: db150889. [Epub ahead of print]
• The gut-brain axis is of great importance in the control of energy homeostasis. The identification of uroguanylin (UGN), an intestinal released peptide regulated by nutritional status and with anorectic actions, as the endogenous ligand for guanylyl cyclase 2C (GUCY2C) receptor, has revealed a new s
• PMID 26566631

• Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis.

• Shailubhai K1, Palejwala V1, Arjunan KP1, Saykhedkar S1, Nefsky B1, Foss JA1, Comiskey S1, Jacob GS1, Plevy SE1.
• World journal of gastrointestinal pharmacology and therapeutics.World J Gastrointest Pharmacol Ther.2015 Nov 6;6(4):213-22. doi: 10.4292/wjgpt.v6.i4.213.
• AIM: To evaluate the effect of orally administered plecanatide or dolcanatide, analogs of uroguanylin, on amelioration of colitis in murine models.METHODS: The cyclic guanosine monophosphate (cGMP) stimulatory potency of plecanatide and dolcanatide was measured using a human colon carcinoma T84 cell
• PMID 26558155

• The differential role of renoguanylin in osmoregulation and apical Cl-/HCO3- exchange activity in the posterior intestine of the Gulf toadfish (Opsanus beta).

• Ruhr IM1, Mager EM2, Takei Y3, Grosell M2.
• American journal of physiology. Regulatory, integrative and comparative physiology.Am J Physiol Regul Integr Comp Physiol.2015 Aug 15;309(4):R399-409. doi: 10.1152/ajpregu.00118.2015. Epub 2015 May 27.
• The guanylin family of peptides are effective regulators of intestinal physiology in marine teleosts. In the distal intestinal segments, they inhibit or reverse fluid absorption by inhibiting the absorptive short-circuit current (Isc). The present findings demonstrate that mRNA from guanylin and uro
• PMID 26017493

Japanese Journal

• 消化管ホルモン ウログアニリン : 肥満に対する消化管由来の新たな治療手段となるか

• Nature reviews. Endocrinology 5(1), 36-38, 2012-07
• NAID 40019400133

• Folding Analysis of Prouroguanylin via Specific Intermediates Using Protein Disulfide Isomerase

• Peptide science : proceedings of the ... Japanese Peptide Symposium 2011, 227-228, 2012-03-01
• NAID 10030204305

• Cooperative Communication between the Mature and the Pro-Peptide Region in Prouroguanylin during Folding

• Peptide science : proceedings of the ... Japanese Peptide Symposium 2011, 193-196, 2012-03-01
• NAID 10030204248

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