urocortin

Urocortin
	Rendering based on PDB 2RMF.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2RMF, 3N96
Identifiers
Symbols	UCN ; UI; UROC
External IDs	OMIM: 600945 MGI: 1276123 HomoloGene: 2515 GeneCards: UCN Gene
Gene ontology
Molecular function	• neuropeptide hormone activity; • protein binding; • histone deacetylase inhibitor activity; • corticotropin-releasing hormone receptor 1 binding; • corticotropin-releasing hormone receptor 2 binding;
Cellular component	• extracellular region; • dendrite; • varicosity; • perikaryon; • axon terminus;
Biological process	• inflammatory response; • response to oxidative stress; • G-protein coupled receptor signaling pathway; • neuropeptide signaling pathway; • female pregnancy; • sensory perception of sound; • associative learning; • aerobic respiration; • negative regulation of gene expression; • pancreatic juice secretion; • positive regulation of cell growth; • positive regulation of cAMP biosynthetic process; • negative regulation of histone deacetylation; • neuron projection development; • negative regulation of appetite; • response to estradiol; • positive regulation of interleukin-6 production; • positive regulation of collagen biosynthetic process; • positive regulation of peptidyl-serine phosphorylation; • activation of protein kinase A activity; • social behavior; • gastric emptying; • drinking behavior; • negative regulation of apoptotic process; • positive regulation of vascular permeability; • positive regulation of translation; • positive regulation of DNA replication; • negative regulation of blood pressure; • negative regulation of cell size; • positive regulation of vasodilation; • negative regulation of hormone secretion; • response to pain; • response to glucocorticoid; • positive regulation of corticotropin secretion; • regulation of synaptic transmission, glutamatergic; • positive regulation of cardiac muscle contraction; • negative regulation of gastric acid secretion; • negative regulation of necrotic cell death; • positive regulation of calcium ion import; • negative regulation of neuron death; • negative regulation of feeding behavior; • positive regulation of behavioral fear response;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/27 00:29:17」(JST)

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[Wiki en表示]

Urocortin is a protein that in humans is encoded by the UCN gene.^[1]^[2]^[3]

Function

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain, it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.^[3]

Urocortin is a potent anorexigenic peptide of 40 amino acids that induces fed-like motor activity when administered centrally or peripherally in fasted animals. Urocortin belongs to the corticotropin-releasing factor (CRF) family that includes CRF, urotensin I, sauvagine, urocortin II and urocortin III. Urocortin is also a potent and long-lasting hypotensive agent and increases coronary blood flow.

Interactions

Urocortin has been shown to interact with Corticotropin releasing hormone receptor 1.^[4]^[5]

References

^ Zhao L, Donaldson CJ, Smith GW, Vale WW (April 1999). "The structures of the mouse and human urocortin genes (Ucn and UCN)". Genomics 50 (1): 23–33. doi:10.1006/geno.1998.5292. PMID 9628819.
^ Tsarev OB (July 1977). "[Dynamics of matrix synthesis in molecular biophysics. II. Principle of insertability and the single-valued solution of feedback tasks]". Biofizika 22 (2): 197–200. PMID 861256.
^ ^a ^b "Entrez Gene: UCN urocortin".
^ Donaldson CJ, Sutton SW, Perrin MH, Corrigan AZ, Lewis KA, Rivier JE, Vaughan JM, Vale WW (May 1996). "Cloning and characterization of human urocortin". Endocrinology 137 (5): 2167–70. doi:10.1210/en.137.5.2167. PMID 8612563.
^ Gottowik J, Goetschy V, Henriot S, Kitas E, Fluhman B, Clerc RG, Moreau JL, Monsma FJ, Kilpatrick GJ (October 1997). "Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin". Neuropharmacology 36 (10): 1439–46. doi:10.1016/S0028-3908(97)00098-1. PMID 9423932.

UpToDate Contents

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1. コルチコトロピン-放出ホルモン（CRH）の生理学 physiology of corticotropin releasing hormone
2. 妊娠に対する母体の内分泌系および代謝の適応 maternal endocrine and metabolic adaptation to pregnancy
3. 胎盤の発達および生理学 placental development and physiology
4. 分娩の生理学 physiology of parturition
5. Genetic contribution and pathophysiology of obesity

English Journal

Angiotensin II's role in sodium lactate-induced panic-like responses in rats with repeated urocortin 1 injections into the basolateral amygdala: Amygdalar angiotensin receptors and panic.

Johnson PL, Sajdyk TJ, Fitz SD, Hale MW, Lowry CA, Hay-Schmidt A, Shekhar A.SourceDepartment of Anatomy & Cell Biology, Indiana University School of Medicine, Indianapolis, IN, United States; Institute of Psychiatric Research Departments of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2013 Jul;44:248-56. doi: 10.1016/j.pnpbp.2013.02.014. Epub 2013 Mar 21.
Rats treated with three daily urocortin 1 (UCN) injections into the basolateral amygdala (BLA; i.e., UCN/BLA-primed rats) develop prolonged anxiety-associated behavior and vulnerability to panic-like physiological responses (i.e., tachycardia, hypertension and tachypnea) following intravenous infusi
PMID 23523745

Urocortin increased LPS-induced endothelial permeability by regulating the cadherin-catenin complex via corticotrophin-releasing hormone receptor 2.

Wan R, Guo R, Chen C, Jin L, Zhu C, Zhang Q, Xu Y, Li S.SourceDepartment of Pharmacology, Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Nanjing Medical University, Nanjing, P.R. China.
Journal of cellular physiology.J Cell Physiol.2013 Jun;228(6):1295-303. doi: 10.1002/jcp.24286.
Urocortin (Ucn1), a member of corticotrophin-releasing hormone (CRH) family, has been reported to be upregulated in inflammatory diseases and function as an autocrine or paracrine inflammatory mediator. Growing evidence shows that Ucn1 increases the endothelial permeability in inflammatory condition
PMID 23168683

Cellular insulin resistance disrupts leptin-mediated control of neuronal signaling and transcription.

Nazarians-Armavil A, Menchella JA, Belsham DD.SourcePhD, Department of Physiology, University of Toronto, Medical Sciences Building 3247A, 1 Kings College Circle, Toronto, Ontario, Canada M5S 1A8. d.belsham@utoronto.ca.
Molecular endocrinology (Baltimore, Md.).Mol Endocrinol.2013 Jun;27(6):990-1003. doi: 10.1210/me.2012-1338. Epub 2013 Apr 11.
Central resistance to the actions of insulin and leptin is associated with the onset of obesity and type 2 diabetes mellitus, whereas leptin and insulin signaling is essential for both glucose and energy homeostasis. Although it is known that leptin resistance can lead to attenuated insulin signalin
PMID 23579487

Japanese Journal

Urocortin Iの心筋細胞における抗酸化作用の検討 (第129回成医会総会一般演題)

池田惠一,藤岡宏樹,東條克能,馬目佳信
東京慈恵会医科大学雑誌 127(6), 235-235, 2012-11-15
NAID 120005104571

ACTH response to desmopressin in a patient with acromegaly ; Expression of corticotropin-releasing factor, urocortins and vasopressin V1b receptor in GH-producing pituitary adenoma

ARIHARA Zenei,SAKURAI Kanako,OSAKI Yoshinori,FUKAZAWA Hiroshi,YAMADA Shozo,INOSHITA Naoko,MURAKAMI Osamu,OHBA Koji,TAKAHASHI Kazuhiro
Endocrine journal 58(12), 1029-1036, 2011-12-01
NAID 10030392435