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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/08 04:25:19」(JST)
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| Uridine triphosphate |
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IUPAC name
[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan- 2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate
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| Identifiers |
| CAS number |
63-39-8 Y |
| PubChem |
1181 |
| MeSH |
Uridine+triphosphate |
| ChEMBL |
CHEMBL605653 N |
| Properties |
| Molecular formula |
C9H15N2O15P3 |
| Molar mass |
484.141 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) |
| N (verify) (what is: Y/N?) |
| Infobox references |
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Uridine-5'-triphosphate (UTP) is a pyrimidine nucleoside triphosphate, consisting of the organic base uracil linked to the 1' carbon of the ribose sugar, and esterified with tri-phosphoric acid at the 5' position. Its main role is as substrate for the synthesis of RNA during transcription.
Role in metabolism
UTP also has the role of a source of energy or an activator of substrates in metabolic reactions, like that of ATP, but more specific. When UTP activates a substrate, UDP-substrate is usually formed and inorganic phosphate is released. UDP-glucose enters the synthesis of glycogen. UTP is used in the metabolism of galactose, where the activated form UDP-galactose is converted to UDP-glucose. UDP-glucuronate is used to conjugate bilirubin to a more water-soluble bilirubin diglucuronide.
Role in receptor mediation
UTP also has roles in mediating responses by extracellular binding to the P2Y receptors of cells. UTP and its derivatives are still being investigated for their applications in human medicine.
See also
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Nucleic acid constituents
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| Nucleobase |
- Purine
- Adenine
- Guanine
- Hypoxanthine
- Xanthine
- Purine analogue
- Pyrimidine
- Uracil
- Thymine
- Cytosine
- Pyrimidine analogue
- Unnatural base pair (UBP)
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| Nucleoside |
| Ribonucleoside |
- Adenosine
- Guanosine
- 5-Methyluridine
- Uridine
- Cytidine
- Inosine
- Xanthosine
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| Deoxyribonucleoside |
- Deoxyadenosine
- Deoxyguanosine
- Thymidine
- Deoxyuridine
- Deoxycytidine
- Deoxyinosine
- Deoxyxanthosine
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Nucleotide
(Nucleoside monophosphate) |
| Ribonucleotide |
- AMP
- GMP
- m5UMP
- UMP
- CMP
- IMP
- XMP
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| Deoxyribonucleotide |
- dAMP
- dGMP
- dTMP
- dUMP
- dCMP
- dIMP
- dXMP
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| Cyclic nucleotide |
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| Nucleoside diphosphate |
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| Nucleoside triphosphate |
- ATP
- GTP
- m5UTP
- UTP
- CTP
- ITP
- XTP
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- dATP
- dGTP
- dTTP
- dUTP
- dCTP
- dITP
- dXTP
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- Biochemical families
- carbohydrates
- alcohols
- glycoproteins
- glycosides
- lipids
- eicosanoids
- fatty acids / intermediates
- glycerides
- phospholipids
- sphingolipids
- steroids
- nucleic acids
- constituents / intermediates
- proteins
- amino acids / intermediates
- tetrapyrroles / intermediates
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UpToDate Contents
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- 1. フルオロピリミジンによる心毒性：発生率、臨床症状、発生機序、マネージメントfluoropyrimidine associated cardiotoxicity incidence clinical manifestations mechanisms and management [show details]
…related to its metabolite fluorouridine triphosphate (FUTP). Uridine is a naturally occurring pyrimidine nucleoside that augments cellular uridine triphosphate (UTP) pools and competes with FUTP for incorporation …
- 2. 運動生理学exercise physiology [show details]
…oxygen binding protein myoglobin, a high content of oxidative enzymes for producing adenosine triphosphate (ATP), and a high density of mitochondria . These fibers tend to be fatigue resistant and are …
- 3. 術後に生じる電解質異常の概要overview of postoperative electrolyte abnormalities [show details]
…commonly observed as extracellular phosphate is rapidly taken into the cells to generate adenosine triphosphate (ATP). Hypokalemia and hypocalcemia are also commonly observed. Malnourished patients should…
- 4. 拡張能障害の細胞学的機序cellular mechanisms of diastolic dysfunction [show details]
…myocyte relaxation include: Ischemia and/or hypoxia; Cellular calcium overload and/or adenosine triphosphate (ATP) depletion; Certain cardiovascular drugs, eg, digitalis; The hypertrophy process itself which …
- 5. 薬と肝臓：代謝および肝障害の機序drugs and the liver metabolism and mechanisms of injury [show details]
… Phase II reactions occur predominantly within the hepatocyte cytoplasm via the uridine diphospho (UDP)-glucuronyl transferases (UGT),… The biliary transporters are members of the adenosine triphosphate (ATP)-binding cassette (ABC) superfamily and include…
English Journal
- Synthesis of photocaged 6-O-(2-nitrobenzyl)guanosine and 4-O-(2-nitrobenzyl) uridine triphosphates for photocontrol of the RNA transcription reaction.
- Ohno K1, Sugiyama D1, Takeshita L1, Kanamori T1, Masaki Y1, Sekine M1, Seio K2.
- Bioorganic & medicinal chemistry.Bioorg Med Chem.2017 Nov 1;25(21):6007-6015. doi: 10.1016/j.bmc.2017.09.032. Epub 2017 Sep 21.
- PMID 28986114
- Abiotic production of sugar phosphates and uridine ribonucleoside in aqueous microdroplets.
- Nam I1,2, Lee JK1, Nam HG3,4, Zare RN5.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2017 Oct 23. pii: 201714896. doi: 10.1073/pnas.1714896114. [Epub ahead of print]
- PMID 29078402
- Synapse formation in the brain can be enhanced by co-administering three specific nutrients.
- Wurtman RJ1.
- European journal of pharmacology.Eur J Pharmacol.2017 Oct 12. pii: S0014-2999(17)30624-6. doi: 10.1016/j.ejphar.2017.09.038. [Epub ahead of print]
- PMID 29031899
Japanese Journal
- ウンシュウミカン茎における着果が低分子物質に及ぼす影響
- 西川 芙美恵,岩崎 光徳,深町 浩 [他],松本 光
- The Horticulture Journal 85(1), 23-29, 2016
- カンキツ樹では，着果が花成と樹の栄養状態に影響する．このため，着果過多あるいは過少になると翌春に花数が変動する．この特性は，豊作と不作を交互に繰り返す隔年結果を引き起こす．隔年結果に関連する代謝産物を明らかにするために，11 月に採取された春枝の茎組織を用いて，代謝産物量を網羅的に調査した．本研究では，着果量の異なるウンシュウミカン 12 樹を使用した．それぞれの樹における着果量は，11 月茎組織 …
- NAID 130005121328
- Ca<sup>2+</sup> dependent but PKC independent signalling mediates UTP induced contraction of rat mesenteric arteries
- Panhwar Fouzia,Rainbow Richard D,Jackson Robert,Davies Noel W
- Ｊｏｕｒｎａｌ ｏｆ Ｓｍｏｏｔｈ Ｍｕｓｃｌｅ Ｒｅｓｅａｒｃｈ 51(0), 58-69, 2015
- … Uridine triphosphate (UTP) can be released from damaged cells to cause vasoconstriction. …
- NAID 130005103357
- Purinergic Signaling Is a Novel Mechanism of the Cellular Response to Ionizing Radiation
- Tsukimoto Mitsutoshi
- Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ 38(7), 951-959, 2015
- … On the other hand, it is known that extracellular ATP, ADP, uridine 5′-triphosphate (UTP), and uridine 5′-diphosphate (UDP), which are released from cells, act as intercellular signaling molecules by activating purinergic P2X and P2Y receptors (purinergic signaling). …
- NAID 130005086282
Related Links
- INS316 is a short-acting, aerosolized uridine 5-triphosphate (UTP) solution used as a diagnostic aid for lung cancer. INS316 appears to improve sputum expectoration mediated through the P2Y2 receptor, a nucleotide receptor ...
- 7.3 Tip If possible, use a magnetic stirrer. This is to ensure a homogeneous enzymatic reaction throughout the allotted time. 7.4 Tip The final concentration of CTPS can be decreased or increased if needed without majorly affecting ...
- Biochem/physiol Actions P2Y receptor agonist. Uridine-5′-Triphosphate (UTP) is a cytosolic nucleotide component of nucleic acids. It serves as a signaling molecule in the extracellular space. Uridine-5′-Triphosphate (UTP) is ...
★リンクテーブル★
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[★]
- 英
- uridine triphosphate、UTP
[★]
三リン酸エステル、三リン酸塩、三リン酸
- 関
- trisphosphate