同: UDP／ UDPGlc

WordNet

a monosaccharide sugar that has several forms; an important source of physiological energy

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/09/17 18:11:19」(JST)

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Uridine diphosphate glucose (uracil-diphosphate glucose, UDP-glucose) is a nucleotide sugar. It is involved in glycosyltransferase reactions in metabolism.

Functions

It is used in nucleotide sugars metabolism as an activated form of glucose as a substrate for enzymes called glucosyltransferases.^[1]

It is a precursor of glycogen and can be converted into UDP-galactose and UDP-glucuronic acid, which can then be used as substrates by the enzymes that make polysaccharides containing galactose and glucuronic acid.

UDP-glucose can also be used as a precursor of sucrose lipopolysaccharides, and glycosphingolipids.

Components

UDP-glucose consists of the pyrophosphate group, the pentose sugar ribose, glucose, and the nucleobase uracil.

References

^ Rademacher T, Parekh R, Dwek R (1988). "Glycobiology". Annu Rev Biochem 57: 785–838. doi:10.1146/annurev.bi.57.070188.004033. PMID 3052290.

UpToDate Contents

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1. 成人糖尿病患者のマネージメントにおける血糖の自己モニタリング（SMBG） blood glucose self monitoring in management of adults with diabetes mellitus
2. 乳児および小児における低血糖に対するアプローチ approach to hypoglycemia in infants and children
3. グルコース-6-リン酸脱水素酵素欠損症の診断および治療 diagnosis and treatment of glucose 6 phosphate dehydrogenase deficiency
4. ガラクトース血症：臨床的特徴および診断 galactosemia clinical features and diagnosis
5. 糖尿病性多発性神経障害の病因および予防 pathogenesis and prevention of diabetic polyneuropathy

English Journal

Kinetic studies on recombinant UDP-glucose: sterol 3-O-β-glycosyltransferase from Micromonospora rhodorangea and its bioconversion potential.

Hoang NH1, Huong NL1, Kim B2, Park JW3.
AMB Express.AMB Express.2016 Dec;6(1):52. doi: 10.1186/s13568-016-0224-x. Epub 2016 Aug 2.
Kinetics of a recombinant uridine diphosphate-glucose: sterol glycosyltransferase from Micromonospora rhodorangea ATCC 27932 (MrSGT) were studied using a number of sterols (including phytosterols) as glycosyl acceptors. The lowest K m value and the highest catalytical efficiency (k cat/K m) were fou
PMID 27485517

The Characterization of Three Glucosyltransferase Genes in Tartary Buckwheat and their Expression after Cold Stress.

Zhou J, Li C, Gao F, Luo XP, Li QQ, Zhao HX, Yao H, Chen H, Wang AH, Wu Q.
Journal of agricultural and food chemistry.J Agric Food Chem.2016 Aug 29. [Epub ahead of print]
Anthocyanins confer the red color in the hypocotyl of tartary buckwheat sprouts. Uridine diphosphate (UDP)-glucose:flavonoid 3-O-glycosyltransferase (UFGT) stabilizes anthocyanin by attaching the glucosyl moiety from UDP-glucose to the C3 hydroxyl of anthocyanin. In this study, we characterized thre
PMID 27571449

Engineering Saccharomyces cerevisiae with the deletion of endogenous glucosidases for the production of flavonoid glucosides.

Wang H1, Yang Y1, Lin L2, Zhou W3, Liu M3, Cheng K3, Wang W4.
Microbial cell factories.Microb Cell Fact.2016 Aug 4;15(1):134. doi: 10.1186/s12934-016-0535-2.
BACKGROUND: Glycosylation of flavonoids is a promising approach to improve the pharmacokinetic properties and biological activities of flavonoids. Recently, many efforts such as enzymatic biocatalysis and the engineered Escherichia coli biotransformation have increased the production of flavonoid gl
PMID 27491546

Japanese Journal

The Effect of Fruit Bearing on Low-molecular-weight Metabolites in Stems of Satsuma Mandarin (Citrus unshiu Marc.)

Nishikawa Fumie,Iwasaki Mitsunori,Fukamachi Hiroshi,Matsumoto Hikaru
The Horticulture Journal advpub(0), 2016
… Other coenzymes such as uridine triphosphate, nicotinamide adenine dinucleotide phosphate, and ascorbic acid were also more abundant in the off-crop trees. … In addition, the off-crop trees accumulated sugar phosphates such as fructose 6-phosphate, glucose 6-phosphate, and ribulose 1,5-diphosphate. …
NAID 130005083312

Glucosyltransferase activity of Arabidopsis UGT71C1 towards pinoresinol and lariciresinol

Okazawa Atsushi,Kusunose Tatsuya,Ono Eiichiro [他],Kim Hyun Jung,Satake Honoo,Shimizu Bun-ichi,Mizutani Masaharu,Seki Hikaru,Muranaka Toshiya
Plant Biotechnology 31(5), 561-566, 2014
Lignans are a class of phenylpropanoids that are widely distributed in the plant kingdom and some lignans are known to be present as glycosides. In the model plant Arabidopsis thaliana, pinoresinol an …
NAID 130004721165

Glucosyltransferase activity of Arabidopsis UGT71C1 towards pinoresinol and lariciresinol

Okazawa Atsushi,Kusunose Tatsuya,Ono Eiichiro,Kim Hyun Jung,Satake Honoo,Shimizu Bun-ichi,Mizutani Masaharu,Seki Hikaru,Muranaka Toshiya
Plant Biotechnology, 2014
Lignans are a class of phenylpropanoids that are widely distributed in the plant kingdom and some lignans are known to be present as glycosides. In the model plant Arabidopsis thaliana, pinoresinol an …
NAID 130004704192

Related Pictures

★リンクテーブル★

リンク元	「ウリジン二リン酸グルコース」
拡張検索	「uridine diphosphate glucose pyrophosphorylase」
関連記事	「diphosphate」

「ウリジン二リン酸グルコース」

Uridine diphosphate glucose
	IUPAC name [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate
	Other names UDP-glucose
Identifiers
CAS number	133-89-1
PubChem	8629
ChemSpider	8308
MeSH	Uridine+Diphosphate+Glucose
ChEBI	CHEBI:52249
ChEMBL	CHEMBL375951
IUPHAR ligand	1783
Jmol-3D images	Image 1
	SMILES O=P(O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)CO)(O)OP(=O)(O)OC[C@H]3O[C@@H](N2/C=C\C(=O)NC2=O)[C@H](O)[C@@H]3O ;
	InChI InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1 ; Key: HSCJRCZFDFQWRP-JZMIEXBBSA-N InChI=1/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1; Key: HSCJRCZFDFQWRP-JZMIEXBBBU ;
Properties
Molecular formula	C15H24N2O17P2
Molar mass	566.302 g/mol
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references