UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

English Journal

A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification.

Iverson SV1, Eriksson S, Xu J, Prigge JR, Talago EA, Meade TA, Meade ES, Capecchi MR, Arnér ES, Schmidt EE.
Free radical biology & medicine.Free Radic Biol Med.2013 Oct;63:369-80. doi: 10.1016/j.freeradbiomed.2013.05.028. Epub 2013 Jun 3.
Besides helping to maintain a reducing intracellular environment, the thioredoxin (Trx) system impacts bioenergetics and drug metabolism. We show that hepatocyte-specific disruption of Txnrd1, encoding Trx reductase-1 (TrxR1), causes a metabolic switch in which lipogenic genes are repressed and peri
PMID 23743293

Establishment of rat precision-cut fibrotic liver slice technique and its application in verapamil metabolism.

Guo Y1, Wang H, Zhang C.
Clinical and experimental pharmacology & physiology.Clin Exp Pharmacol Physiol.2007 May-Jun;34(5-6):406-13.
1. Liver fibrosis is the compensatory state of cirrhosis. In the long asymptomatic period, it is imperative to select a proper dosing regimen for drugs that are applicable to hepatic fibrosis. Otherwise, progressive deterioration to uncompensated cirrhosis may occur. The present study explored the c
PMID 17439408

Liquid chromatography/mass spectrometry of plasma glucose and secreted glucuronate for metabolic studies in humans.

Reid S1, Shackleton C, Wu K, Kaempfer S, Hellerstein MK.
Biomedical & environmental mass spectrometry.Biomed Environ Mass Spectrom.1990 Sep;19(9):535-40.
Negative ion thermospray liquid chromatographic/mass spectrometric methods have been developed for the determination of isotopic enrichments for glucose and acetaminophen-uridine diphosphate glucuronate from (1-2H1)glucose, (1-2H1)galactose and (2-13C)acetate in humans. The error of estimate ranged
PMID 2224180