WordNet

exert oneself to meet a challenge; "rise to a challenge"; "rise to the occasion"
increase in value or to a higher point; "prices climbed steeply"; "the value of our house rose sharply last year" (同)go_up, climb
rise in rank or status; "Her new novel jumped high on the bestseller list" (同)jump, climb up
the act of changing location in an upward direction (同)ascent, ascension, ascending
an increase in cost; "they asked for a 10% rise in rates" (同)boost, hike, cost increase
a movement upward; "they cheered the rise of the hot-air balloon" (同)rising, ascent, ascension
a growth in strength or number or importance
come up, of celestial bodies; "The sun also rises"; "The sun uprising sees the dusk night fled..."; "Jupiter ascends" (同)come_up, uprise, ascend
move upward; "The fog lifted"; "The smoke arose from the forest fire"; "The mist uprose from the meadows" (同)lift, arise, move up, go_up, come_up, uprise
rise up; "The building rose before them" (同)lift, rear
increase in volume; "the dough rose slowly in the warm room" (同)prove
become heartened or elated; "Her spirits rose when she heard the good news"
earn on some commercial or business transaction; earn as salary or wages; "How much do you make a month in your new job?"; "She earns a lot in her new job"; "this merger brought in lots of money"; "He clears $5,000 each month" (同)take_in, clear, make, earn, realize, realise, pull_in, bring_in
increase or develop; "the peace movement gained momentum"; "the car gathers speed" (同)gather
increase (ones body weight); "She gained 20 pounds when she stopped exercising" (同)put_on
the amount by which the revenue of a business exceeds its cost of operating
obtain advantages, such as points, etc.; "The home team was gaining ground"; "After defeating the Knicks, the Blazers pulled ahead of the Lakers in the battle for the number-one playoff berth in the Western Conference" (同)advance, win, pull ahead, make headway, get ahead, gain ground
a process of becoming larger or longer or more numerous or more important; "the increase in unemployment"; "the growth of population" (同)increment, growth
become bigger or greater in amount; "The amount of work increased"
make bigger or more; "The boss finally increased her salary"; "The university increased the number of students it admitted"
the amount by which something increases; "they proposed an increase of 15 percent in the fare" (同)increment
the act of increasing something; "he gave me an increase in salary" (同)step-up
a change resulting in an increase; "the increase is scheduled for next month"
in several ways; in a multiple manner; "they were multiply checked for errors"
combine or increase by multiplication; "He managed to multiply his profits" (同)manifold
combine by multiplication; "multiply 10 by 15"
used up; "time is up"
raise; "up the ante"
extending or moving toward a higher place; "the up staircase"; "a general upward movement of fish" (同)upward
to a later time; "they moved the meeting date up"; "from childhood upward" (同)upwards, upward
spatially or metaphorically from a lower to a higher position; "look up!"; "the music surged up"; "the fragments flew upwards"; "prices soared upwards"; "upwardly mobile" (同)upwards, upward, upwardly
(used of computers) operating properly; "how soon will the computers be up?"
(usually followed by `on or `for'
being or moving higher in position or greater in some value; being above a former position or level; "the anchor is up"; "the sun is up"; "he lay face up"; "he is up by a pawn"; "the market is up"; "the corn is up"
nearer to the speaker; "he walked up and grabbed my lapels"
open; "the windows are up"
to a higher intensity; "he turned up the volume"
to a more central or a more northerly place; "was transferred up to headquarters"; "up to Canada for a vacation"
prescribed by or according to regulation; "regulation army equipment"
(embryology) the ability of an early embryo to continue normal development after its structure has been somehow damaged or altered
the state of being controlled or governed
the act of bringing to uniformity; making regular (同)regularization, regularisation
the act of controlling or directing according to rule; "fiscal regulations are in the hands of politicians" (同)regulating
an authoritative rule (同)ordinance
(chiefly British) of or appropriate to the upper classes especially in language use

PrepTutorEJDIC

《文》『立ち上がる』《+『up』》 / 《文》『起床する』,起きる / (下から上へ)『上がる』,上昇する,昇る / 〈土地が〉上り[坂]になる / 〈山・建物などが〉そびえ立つ(進行形にできない) / 〈…の数量・価値・程度・力などが〉増す,増大する,増加する / 〈地位・身分などが〉(…から…へ)上がる,高くなる《+『from』+『名』+『to』+『名』》 / 〈川などが〉高さを増す,増水する / 〈パンなどが〉ふくれる / (…に)源を発する,始まる《+『from』(『in』)+『名』》(進行形にできない) / (…に)反乱を起こす,背いて立ち上がる《+『against』+『名』》 / 生き返る,よみがえる / (表面に)浮かび上がる / (…に)応じて立ち上がる,うまく対処する《+『to』+『名』》 / 〈C〉(…の)『上昇』《+『of』+『名』》 / 〈C〉(数量・価値・程度などの)増大,増加《+『in』(『of』)+『名』》 / 〈U〉立身;繁栄 / 〈C〉(…の)上り坂,上り勾配(こうばい)《+『in』(『of』)+『名』》 / 〈C〉丘,高台 / 〈C〉(…の)起源,始まり《+『of』+『名』》 / 《英話》昇給,昇給額(《米》raise) / 〈C〉魚がえさを求めて水面に浮き上がること
(努力して)…‘を'『得る』,手に入れる / …‘を'『増す』 / 〈競争など〉‘に'勝つ;〈賞など〉‘を'勝ち取る / 《文》(特に努力をして)〈目指す場所〉‘に'到達する;〈目的など〉‘を'達成する / 得をする / (…において)進歩する,よくなる,向上する;(体重・身長・能力など)増す《+in+名》 / 〈時計が〉進む / 〈C〉(…に)加えたもの《+『to』+『名』》;(…において)増加したもの《+『in』+『名』》 / 《複数形で》『利益』(profits);賞金 / 〈U〉利益を得ること,獲得
『増える』,『増大する』 / (…に)…‘を'『増やす』《+『名』+『to』+『名』》 / (…の)『増加』,増大;〈C〉増加量(額)《+『of』(『in』,『on』)+『名』》
…‘を'『増す』,ふやす;…‘を'繁殖させる / (ある数を)〈ある数〉‘に'『掛ける』《+『名』〈被乗数〉+『by』+『名』〈乗数〉》 / 〈数・量などが〉『ふえる』,増大する;繁殖する / 掛け算をする
多様に,複雑に,複合的に
(ある高さに)…‘を'『上げる』,‘の'程度を高める《『名』+『to』+『名』》 / (知的・精神的に)…‘を'向上させる,高める / (…から…に)〈人〉‘を'昇進させる《+『from』+『名』+『to』+『名』》
《上への動作》『上へ』,上のほうへ / 《上の位置》『上に』,上のほうで / 『起こして』,立てて,直立して / (地図・紙面などの)『上へ(に)』,北のほうへ(に) / (遠くから)『近くへ,中心へ』;(周辺から)中心へ;(川下から)川上へ;(地方から)都会へ / (大きさ・量・価値・地位などが)『上のほうへ』,高く / (話者,話題の場所へ)『近づいて』,追いついて / 『活動して』,活動状態に / (物事・人が)現れて・起こって / 『すっかり』,完全に,終わって,…し尽くして / 保管(貯蔵)して;くるんだ(閉ざした)状態に / 《動詞を省略した命令文で》 / (野球・クリケットで)打席へ / (競技で)勝ち越して / (対抗の競技で)おのおの / 《移動・位置》『…の高いほうへ』,をのぼって;…の上のほうに / (川の)『上流へ』;(流れ・風)に逆らって;…の内陸(奥地)のほうへ / (自分が今いる所,またはある地点から前方へ)『…に沿って』 / 『上へ向かう』,(列車などが)上りの;上り坂の,(情勢などが)上向きの / 上り,上昇,上り坂 / 上昇気運,向上,幸運 / 上りの列車(バス・エレボーターなど) / 値上がり / …‘を'持ち上げる / …‘を'増大する,〈賃金・物価など〉‘を'引き上げる / 〈人〉‘を'昇進させる / 立ち上がる,起き上がる / 《and を伴って》急に(突然)…する
〈C〉『規則』,『規定』;法規,条例 / 〈U〉(…の)『規制』,『調整』《+『of』+『名』》 / 正規の,規定どおりの

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/03/14 10:36:14」(JST)

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[Wiki en表示]

Downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external variable. An increase of a cellular component is called upregulation.

An example of downregulation is the cellular decrease in the number of receptors to a molecule, such as a hormone or neurotransmitter, which reduces the cell's sensitivity to the molecule. This phenomenon is an example of a locally acting negative feedback mechanism.

An example of upregulation is the increased number of cytochrome P450 enzymes in liver cells when xenobiotic molecules such as dioxin are administered (resulting in greater degradation of these molecules).

Some receptor agonists may cause downregulation of their respective receptor(s), while most receptor antagonists may temporally upregulate their respective receptor(s). The disequilibrium caused by these changes often causes withdrawal when the long-term use of a medication or drug is discontinued. However, the use of certain receptor antagonists may also damage receptors faster than they upregulate (internalization of receptors due to antagonism).^{[citation needed]}

Upregulation and downregulation can also happen as a response to toxins or hormones. An example of upregulation in pregnancy is hormones that cause cells in the uterus to become more sensitive to oxytocin.

§Receptor downregulation

§Insulin receptor mechanism

The process of downregulation occurs when there are elevated levels of the hormone insulin in the blood. When insulin binds to its receptors on the surface of a cell, the hormone receptor complex undergoes endocytosis and is subsequently attacked by intracellular lysosomal enzymes. The internalization of the insulin molecules provides a pathway for degradation of the hormone as well as for regulation of the number of sites that are available for binding on the cell surface. At high plasma concentrations, the number of surface receptors for insulin is gradually reduced by the accelerated rate of receptor internalization and degradation brought about by increased hormonal binding. The rate of synthesis of new receptors within the endoplasmic reticulum and their insertion in the plasma membrane do not keep pace with their rate of destruction. Over time, this self-induced loss of target cell receptors for insulin reduces the target cell’s sensitivity to the elevated hormone concentration. The process of decreasing the number of receptor sites is virtually the same for all hormones; it varies only in the receptor hormone complex.

§Cases

This process is illustrated by the insulin receptor sites on target cells in a person with type 2 diabetes. Due to the elevated levels of blood glucose in an overweight individual, the β-cells (islets of Langerhans) in the pancreas must release more insulin than normal to meet the demand and return the blood to homeostatic levels. The near-constant increase in blood insulin levels results from an effort to match the increase in blood glucose, which will cause receptor sites on the liver cells to downregulate and decrease the number of receptors for insulin, increasing the subject’s resistance by decreasing sensitivity to this hormone. There is also a hepatic decrease in sensitivity to insulin. This can be seen in the continuing gluconeogenesis in the liver even when blood glucose levels are elevated. This is the more common process of insulin resistance, which leads to adult-onset diabetes.

Another example can be seen in diabetes insipidus, in which the kidneys become insensitive to arginine vasopressin.

§Reversal

The process of downregulation can be counteracted in the above example. A person with type 2 diabetes can increase their sensitivity to insulin through proper diet and regular exercise, resulting in weight loss; some individuals may even return to their pre-diabetic state by following such a regimen.

§See also

Regulation of gene expression
Desensitization (medicine)

§References

Sherwood, L. (2004). “Human Physiology From Cells to Systems, 5th Ed” (p. 680). Belmont, CA: Brooks/Cole-Thomson Learning

Wilmore, J., Costill, D. (2004). Physiology of Sport and Exercise, 3rd Ed (p. 164). Champaign, IL: Human Kinetics

§External links

Down-Regulation at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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