unstable hemoglobin disease

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  • Relationship of dental diseases with coronary artery diseases and diabetes in Bangladesh.
  • Choudhury AR1, Choudhury KN1, Islam SM1.
  • Cardiovascular diagnosis and therapy.Cardiovasc Diagn Ther.2016 Apr;6(2):131-7. doi: 10.21037/cdt.2016.02.05.
  • BACKGROUND: Evidence suggests that dental diseases might have a role in the development and progression of coronary artery diseases (CAD) and diabetes mellitus (DM). The objective of this study was to determine the relationship of dental diseases with CAD and DM in Bangladesh.METHODS: We conducted a
  • PMID 27054102
  • HB Puerta del Sol [HBA1:c.148A>C], HB Valdecilla [HBA2:c.3G>T], HB Gran Vía [HBA2:c.98T>G], HB Macarena [HBA2:c.358C>T] and HB El Retiro [HBA2:c.364_366dupGTG]: description of five new hemoglobinopathies.
  • de la Fuente-Gonzalo F, Nieto JM, Velasco D, Cela E, Pérez G, Fernández-Teijeiro A, Escudero A, Villegas A, González-Fernández FA, Ropero P.
  • Clinical chemistry and laboratory medicine.Clin Chem Lab Med.2016 Apr 1;54(4):553-60. doi: 10.1515/cclm-2015-0649.
  • BACKGROUND: Structural hemoglobinopathies do not usually have a clinical impact, but they can interfere with the analytical determination of some parameters, such as the glycated hemoglobin in diabetic patients. Thalassemias represent a serious health problem in areas where their incidence is high.
  • PMID 26485748


  • Clinical Predictors of Contrast-Induced Acute Kidney Injury in Patients Undergoing Emergency Versus Elective Percutaneous Coronary Intervention:– Results From the Ibaraki Cardiovascular Assessment Study Registry –
  • Abe Daisuke,Sato Akira,Hoshi Tomoya,Kakefuda Yuki,Watabe Hiroaki,Ojima Eiji,Hiraya Daigo,Harunari Tomohiko,Takeyasu Noriyuki,Aonuma Kazutaka
  • Circulation Journal, 2013
  • … Background: To evaluate the incidence and clinical predictors of contrast-induced acute kidney injury (CI-AKI) in patients with ST-segment elevation myocardial infarction (STEMI), unstable angina pectoris/non-STEMI (UAP/NSTEMI), and stable AP (SAP) undergoing percutaneous coronary intervention (PCI). … P=0.005), and hemoglobin <10g/dl (OR 0.02; …
  • NAID 130003382178
  • 生活習慣病に潜む心理社会的ストレス(パネルディスカッション : 生活習慣病と心身医学,2007年,第48回日本心身医学会総会(福岡))
  • 中尾 睦宏
  • 心身医学 48(3), 195-203, 2008-03-01
  • 心理社会的ストレスは生活習慣病の発症や途中経過に深く関与している.日本で策定されたメタボリックシンドロームの診断基準は,各項目が健康診断で簡便に測定でき,動脈硬化を原因とする心血管疾患を明確なエンドポイントにしているので,生活習慣の予防的戦略が立てやすくなった.今こそ公衆衛生学と臨床医学が一致団結して生活習慣病に取り組むチャンスであり,心身医学はその牽引役になりえる.パネルディスカッションでは心理 …
  • NAID 110006622715


1. Nihon Rinsho. 1996 Sep;54(9):2436-41. [The unstable hemoglobin disease]. [Article in Japanese] Maeda M, Yamamoto M. The unstable hemoglobin disease result from the presence of a structurally abnormal hemoglobin variant ...
[Intro] Unstable hemoglobin disease is due to the α or β globin chain amino acid composition changes resulting in structural instability of the hemoglobin molecule, denaturation and precipitation, the formation of denatured globin bodies in ...






unstable hemoglobinopathy, unstable hemoglobin disease
不安定血色素症不安定ヘモグロビン溶血性貧血 unstable hemoglobin hemolytic anemia先天性ハインツ小体溶血性貧血 congenital Heinz body hemolytic anemia
異常ヘモグロビン症 hemoglobinopathy

  • 異常ヘモグロビンが変性して沈殿し、溶血を促進させる疾患。
  • 溶血貧血を来す → 正球性貧血
  • 赤血球中にハインツ小体が見られる

日本で見られる不安定ヘモグロビン症をきたすグロビンの変異 IMD.960

  • Hb Geneva , β鎖
  • Hb Hammersmith , β鎖
  • Hb Tochigi , β鎖
  • Hb Bristol , β鎖
  • Hb Mizuno , β鎖
  • Hb Koln , β鎖



  • n.
疾患illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)
特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)
  • something that is very wrong with people's attitudes, way of life or with society.
ailailmentdisease entitydisorderillillnessmaladysicksickness
  • 注意

WordNet   license wordnet

「an impairment of health or a condition of abnormal functioning」

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「(体の)『病気』,疾患 / (精神・道徳などの)病気,病弊」

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「女性の話術芸人 =diseur」



  • adj.
  • 不安定な

WordNet   license wordnet

「lacking stability or fixity or firmness; "unstable political conditions"; "the tower proved to be unstable in the high wind"; "an unstable world economy"」

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「(物が)不安定な,ぐらぐらする / 情緒不安定な,落ち着のない / (気候・経済などが)安定性のない,不安定な / (化合物が)分解しやすい」

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「disposed to psychological variability; "his rather unstable religious convictions"」

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「highly or violently reactive; "sensitive and highly unstable compounds"」


  [★] ヘモグロビン

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「a hemoprotein composed of globin and heme that gives red blood cells their characteristic color; function primarily to transport oxygen from the lungs to the body tissues; "fish have simpler hemoglobin than mammals"」
haemoglobin, Hb

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「caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes"」
morbid, pathologic, pathological

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「病気にかかった / 病的な,不健全な(morbid)」