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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/15 07:41:10」(JST)

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Unoprostone (INN) is a prostaglandin analogue. Its isopropyl ester, unoprostone isopropyl, is marketed under the trade name Rescula (eyedrops, 0.15%) for the management of open-angle glaucoma and ocular hypertension.

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1. 原発性乳児緑内障 primary infantile glaucoma

English Journal

A platform for controlled dual-drug delivery to the retina: protective effects against light-induced retinal damage in rats.

Nagai N1, Kaji H, Onami H, Katsukura Y, Ishikawa Y, Nezhad ZK, Sampei K, Iwata S, Ito S, Nishizawa M, Nakazawa T, Osumi N, Mashima Y, Abe T.
Advanced healthcare materials.Adv Healthc Mater.2014 Oct;3(10):1555-60, 1524. doi: 10.1002/adhm.201400114. Epub 2014 Apr 19.
Controlled transscleral co-delivery of two drugs, edaravone (EDV) and unoprostone (UNO), using a platform that comprises a microfabricated reservoir, controlled-release cover, and drug formulations, which are made of photopolymerized poly(ethyleneglycol) dimethacrylates, shows synergistic retinal ne
PMID 24753450

Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa.

Akiyama M, Ikeda Y, Yoshida N, Notomi S, Murakami Y, Hisatomi T, Enaida H, Ishibashi T.
Acta ophthalmologica.Acta Ophthalmol.2014 May;92(3):e229-34.
PURPOSE: To evaluate the therapeutic effect of topical unoprostone isopropyl (unoprostone) on patients with retinitis pigmentosa (RP).METHODS: Forty patients with typical forms of RP were included in the study.Seventeen of 40 patients were treated with 0.12% topical unoprostone twice daily in a rand
PMID 24868583

Activation of the prostanoid FP receptor inhibits adipogenesis leading to deepening of the upper eyelid sulcus in prostaglandin-associated periorbitopathy.

Taketani Y1, Yamagishi R, Fujishiro T, Igarashi M, Sakata R, Aihara M.
Investigative ophthalmology & visual science.Invest Ophthalmol Vis Sci.2014 Mar 4;55(3):1269-76. doi: 10.1167/iovs.13-12589.
PURPOSE: To investigate the effects of prostaglandin (PG) analogues on adipogenesis so as to clarify the mechanism of a side effect of topical PG analogues: deepening of the upper eyelid sulcus (DUES), which has been reported in this decade.METHODS: The 3T3-L1 preadipocytes were treated to promote d
PMID 24508785

Japanese Journal

LABORATORY INVESTIGATION : Regeneration of optic nerve fibers with unoprostone, a prostaglandin-related antiglaucoma drug, in adult cats

Japanese journal of ophthalmology : the official international journal of the Japanese Ophthalmological Society 58(1), 100-109, 2014-01
NAID 40019946996

広義の原発性開放隅角緑内障もしくは高眼圧症に対するコソプト<sup>®</sup>点眼液に変更後の眼圧下降効果

日本医科大学医学会雑誌 9(3), 152-155, 2013
NAID 130004471538

正常眼圧緑内障に対するイソプロピルウノプロストン3年間点眼の眼圧およびセクター別の視野に及ぼす効果

あたらしい眼科 = Journal of the eye 27(11), 1593-1597, 2010-11-30
NAID 10028246726

「ウノプロストン」

Unoprostone
Systematic (IUPAC) name
	(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl); cyclopentyl]hept-5-enoic acid
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	?
Legal status	?
Routes	Topical (eye drops)
Identifiers
CAS number	120373-36-6 120373-24-2
ATC code	S01EE02
PubChem	CID 5311236
UNII	6X4F561V3W
KEGG	D08661
ChEMBL	CHEMBL1201407
Chemical data
Formula	C22H38O5
Mol. mass	382.534 g/mol
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