unfavorably

　

WordNet

1. showing disapproval; in a disparaging way; "he reviewed the play unfavorably" (同)unfavourably

PrepTutorEJDIC

1. 不利に;好意的でなく

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• 1. 気絶心筋または冬眠心筋の病態生理 pathophysiology of stunned or hibernating myocardium
• 2. 塩分摂取量および塩分摂取量制限と原発性（本態性）高血圧 salt intake salt restriction and primary essential hypertension
• 3. 家庭での血液透析 home hemodialysis
• 4. 平均赤血球容積 mean corpuscular volume
• 5. 癌関連疲労：治療 cancer related fatigue treatment

English Journal

• Multilevel structural characteristics for the natural substrate proteins of bacterial small heat shock proteins.

• Fu X, Chang Z, Shi X, Bu D, Wang C.Author information State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, 100871, China.AbstractSmall heat shock proteins (sHSPs) are ubiquitous molecular chaperones that prevent the aggregation of various non-native proteins and play crucial roles for protein quality control in cells. It is poorly understood what natural substrate proteins, with respect to structural characteristics, are preferentially bound by sHSPs in cells. Here we compared the structural characteristics for the natural substrate proteins of Escherichia coli IbpB and Deinococcus radiodurans Hsp20.2 with the respective bacterial proteome at multiple levels, mainly by using bioinformatics analysis. Data indicate that both IbpB and Hsp20.2 preferentially bind to substrates of high molecular weight or moderate acidity. Surprisingly, their substrates contain abundant charged residues but not abundant hydrophobic residues, thus strongly indicating that ionic interactions other than hydrophobic interactions also play crucial roles for the substrate recognition and binding of sHSPs. Further, secondary structure prediction analysis indicates that the substrates of low percentage of β-sheets or coils but high percentage of α-helices are un-favored by both IbpB and Hsp20.2. In addition, IbpB preferentially interacts with multi-domain proteins but unfavorably with α + β proteins as revealed by SCOP analysis. Together, our data suggest that bacterial sHSPs, though having broad substrate spectrums, selectively bind to substrates of certain structural features. These structural characteristic elements may substantially participate in the sHSP-substrate interaction and/or increase the aggregation tendency of the substrates, thus making the substrates more preferentially bound by sHSPs.
• Protein science : a publication of the Protein Society.Protein Sci.2013 Dec 8. doi: 10.1002/pro.2404. [Epub ahead of print]
• Small heat shock proteins (sHSPs) are ubiquitous molecular chaperones that prevent the aggregation of various non-native proteins and play crucial roles for protein quality control in cells. It is poorly understood what natural substrate proteins, with respect to structural characteristics, are pref
• PMID 24318917

• Increasing cell plating density mimics an early post-LH stage in cultured bovine granulosa cells.

• Baufeld A, Vanselow J.Author information Reproductive Biology, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196, Dummerstorf, Germany.AbstractCultured ovarian granulosa cells are essential models to study molecular mechanisms of gene regulation during folliculogenesis. Here, we characterize primary tissue culture models for bovine granulosa cells by morphological and physiological parameters and by novel molecular luteinization markers, as transcript abundance and DNA methylation levels. The data show that: (1) collagen substrate increased the number of attached, viable cells; (2) the expression of the key transcripts of estrogen synthesis, CYP19A1, could be induced and maintained in granulosa cells from small to medium but not from large follicles, whereas (3) only granulosa cells from large but not from smaller follicles were responsive to LH; (4) serum supplementation unfavorably transformed the cellular phenotype, induced proliferation and PCNA expression, reduced or abolished the transcript abundance of steroidogenic key genes and of gonadotropin receptor genes, CYP11A1, CYP19A1, FSHR and LHCGR but, however, did not increase the abundance of the luteinization-specific marker transcripts PTGS2, PTX3, RGS2 and VNN2; but (5) by increasing the plating density, estradiol production and the abundance of CYP19A1 transcripts, in particular those derived from the main ovarian promoter P2, were decreased concurrently leaving P2-specific DNA methylation levels unchanged, whereas progesterone secretion was stimulated and the expression of both luteinization-specific marker transcripts, RGS2 and VNN2, was significantly induced. From these data, we conclude that increasing the plating density induces a different, partly complementary, physiological and gene expression profile in cultured bovine granulosa cells and drives the cells towards an early post-LH stage of luteinization, even in the absence of luteinizing agents.
• Cell and tissue research.Cell Tissue Res.2013 Dec;354(3):869-80. doi: 10.1007/s00441-013-1712-9. Epub 2013 Sep 13.
• Cultured ovarian granulosa cells are essential models to study molecular mechanisms of gene regulation during folliculogenesis. Here, we characterize primary tissue culture models for bovine granulosa cells by morphological and physiological parameters and by novel molecular luteinization markers, a
• PMID 24026437

• Quantification of thoracic blood flow using volumetric magnetic resonance imaging with radial velocity encoding: in vivo validation.

• Frydrychowicz A, Wieben O, Niespodzany E, Reeder SB, Johnson KM, François CJ.Author information From the *University Hospital Schleswig-Holstein, Campus Lübeck, Clinic for Radiology and Nuclear Medicine, Lübeck, Germany; Departments of †Radiology, ‡Medical Physics, §Biomedical Engineering, and ∥Medicine, University of Wisconsin-Madison, Madison, WI.AbstractOBJECTIVES: The objective of this study was to validate radially undersampled 5-point velocity-encoded time-resolved flow-sensitive magnetic resonance imaging (MRI) ("PC-VIPR", phase contrast vastly undersampled imaging with isotropic resolution projection reconstruction magnetic resonance) for the quantification of ascending aortic (AAO) and main pulmonary artery (MPA) flow in vivo.
• Investigative radiology.Invest Radiol.2013 Dec;48(12):819-25. doi: 10.1097/RLI.0b013e31829a4f2f.
• OBJECTIVES: The objective of this study was to validate radially undersampled 5-point velocity-encoded time-resolved flow-sensitive magnetic resonance imaging (MRI) ("PC-VIPR", phase contrast vastly undersampled imaging with isotropic resolution projection reconstruction magnetic resonance) for the
• PMID 23857136

Japanese Journal

• 日本人学習者による英語のリズム制御におけるモーラの影響(感情音声,韻律,声質,音声生成・知覚,脳機能,一般)

• 中村 静,加藤 宏明,匂坂 芳典
• 電子情報通信学会技術研究報告. SP, 音声 109(99), 45-50, 2009-06-17
• 我々は、日本人学習者の英語音声におけるリズム制御に対する客観評価法について研究してきた。この研究の経過で、日本語を母語とする学習者の潜在的なモーラ・タイミングの習慣が,英語のストレス・タイミングの生成に悪い影響を及ぼしているらしいことに注目した。そこで、本研究ではこの影響を調べるために、主にリズム制御に関与する音節の強弱の対比の観点から、母語話者音声に対する学習者音声の対応する種々の音声区分(強勢 …
• NAID 110007340425

• 主題表現法に基づく造形表現力と鑑賞及び評価能力育成に関する考察 : 題材「季節感のある和菓子のデザイン〜仙台市の四季〜」を通して

• 立原 慶一,小野 あけみ
• 宮城教育大学紀要 44, 85-94, 2009
• … Of the three types identified by dividing the content for evaluation by item, in particular need ofconsideration in terms of instruction for the purpose of fostering pupils' art appreciation and evaluation abilitiesare the ten percent of pupils belonging to number two, "the type that ended unfavorably, perhaps because thecontent for evaluation was not itemized." These pupils were unable to perceive any theme in the work, andtheir sensibilities are functioning insufficiently to sense the meaning and sentiment of the work. …
• NAID 110007543437

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• unfavorablyの意味 - 英和辞書 - goo辞書

unfavorablyとは。意味や和訳。[副] ⇒ugrave;n・favorable／((英))-favourable - goo辞書は国語、英和、和英、中国語、百科事典等からまとめて探せる辞書検索サービスです。 ... 辞書すべて 国語 類語 英和 和英 中日 日中 ※「説明文に ...

• Unfavorably | Define Unfavorably at Dictionary.com

Unfavorably definition, not favorable; contrary; adverse: an unfavorable wind. See more. Added to Favorites Dictionary Thesaurus Word Dynamo Quotes Reference Translator Spanish Log In Sign Up Premium unfavorably Use in a / / ...

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