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English Journal
- Polysaccharides isolated from Digenea simplex inhibit inflammatory and nociceptive responses.
- Pereira JG1, Mesquita JX1, Aragão KS2, Franco AX2, Souza MH2, Brito TV3, Dias JM3, Silva RO3, Medeiros JV3, Oliveira JS3, Abreu CM4, de Paula RC4, Barbosa AL5, Freitas AL6.Author information 1Laboratory of Proteins and Carbohydrates of Marine Algae, Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Brazil.2LAFICA - Laboratory of Pharmacology of Inflammation and Cancer, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.3LAFFEX - Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piauí, Parnaiba, Piauí, Brazil.4Polymer Laboratory, Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Brazil.5LAFFEX - Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piauí, Parnaiba, Piauí, Brazil. Electronic address: andreluiz@ufpi.edu.br.6Laboratory of Proteins and Carbohydrates of Marine Algae, Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Brazil. Electronic address: pfreitas@ufc.br.AbstractPolysaccharides (PLS) have notably diverse pharmacological properties. In the present study, we investigated the previously unexplored anti-inflammatory and antinociceptive activities of the PLS fraction isolated from the marine red alga Digenea simplex. We found that the PLS fraction reduced carrageenan-induced edema in a dose-dependent manner, and inhibited inflammation induced by dextran, histamine, serotonin, and bradykinin. The fraction also inhibited neutrophil migration into both mouse paw and peritoneal cavity. This effect was accompanied by decreases in IL1-β and TNF-α levels in the peritoneal fluid. Pre-treatment of mice with PLS (60mg/kg) significantly reduced acetic acid-induced abdominal writhing. This same dose of PLS also reduced total licking time in both phases of a formalin test, and increased latency in a hot plate test. Therefore, we conclude that PLS extracted from D. simplex possess anti-inflammatory and antinociceptive activities and can be useful as therapeutic agents against inflammatory diseases.
- Carbohydrate polymers.Carbohydr Polym.2014 Aug 8;108:17-25. doi: 10.1016/j.carbpol.2014.01.105. Epub 2014 Mar 12.
- Polysaccharides (PLS) have notably diverse pharmacological properties. In the present study, we investigated the previously unexplored anti-inflammatory and antinociceptive activities of the PLS fraction isolated from the marine red alga Digenea simplex. We found that the PLS fraction reduced carrag
- PMID 24751242
- Unilateral cortical hyperexcitability in congenital hydrocephalus: A TMS study.
- Guerra A1, Curcio G, Pasqualetti P, Bressi F, Petrichella S, Scrascia F, Ponzo D, Ferilli M, Vernieri F, Rossini PM, Ferreri F.Author information 1a Department of Neurology , University Campus Bio-Medico , Rome , Italy.AbstractIntroduction: Changes in cortical excitability are considered to play an important role in promoting brain plasticity both in healthy people and in neurological diseases. Hydrocephalus is a brain development disorder related to an excessive accumulation of cerebrospinal fluid (CSF) in the ventricular system. The functional relevance of cortical structural changes described in this disease is largely unexplored in human. We investigated cortical excitability using multimodal transcranial magnetic stimulation (TMS) in a case of congenital hydrocephalus with almost no neurological signs. Methods: A caucasian 40 years old, ambidextrous and multilingual woman affected by occult spina bifida and congenital symmetrical hydrocephalous underwent a TMS study. The intracortical and interhemispheric paired pulse paradigms were used, together with the mapping technique. Results: No significant differences were found in the resting motor thresholds between the two hemispheres. Instead, the intracortical excitability curves were statistically different between the two hemispheres (with short intracortical inhibition (SICI) being strongly reduced and intracortical facilitation (ICF) enhanced in the right one), and the interhemispheric curves showed a general hyper-excitability on the right hemisphere (when conditioned by the left one) and a general hypo-excitability in the left hemisphere (when conditioned by the right one). It is noteworthy that an asymmetric right hemisphere (RH) change of excitability was observed by means of mapping technique. Conclusion: We hypothesize that in this ambidextrous subject, the observed RH hyper-excitability could represent a mechanism of plasticity to preserve functionality of specific brain areas possibly devoted to some special skills, such as multilingualism.
- Neurocase.Neurocase.2014 Aug;20(4):456-65. doi: 10.1080/13554794.2013.791866. Epub 2013 May 17.
- Introduction: Changes in cortical excitability are considered to play an important role in promoting brain plasticity both in healthy people and in neurological diseases. Hydrocephalus is a brain development disorder related to an excessive accumulation of cerebrospinal fluid (CSF) in the ventricula
- PMID 23682715
- Sex differences in response to reduced nicotine content cigarettes.
- Vogel RI1, Hertsgaard LA2, Dermody SS3, Luo X4, Moua L2, Allen S5, Al'absi M6, Hatsukami DK7.Author information 1University of Minnesota, Masonic Comprehensive Cancer Center, Minneapolis, MN, United States.2University of Minnesota, Tobacco Research Programs, Minneapolis, MN, United States.3University of Pittsburgh, Department of Psychology, Pittsburgh, PA, United States.4University of Minnesota, Masonic Comprehensive Cancer Center, Minneapolis, MN, United States; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States.5University of Minnesota, Tobacco Research Programs, Minneapolis, MN, United States; University of Minnesota, Family Medicine and Community Health, Minneapolis, MN, United States.6University of Minnesota, Departments of Family Medicine and Community Health and Behavioral Sciences, Duluth, MN, United States.7University of Minnesota, Masonic Comprehensive Cancer Center, Minneapolis, MN, United States; University of Minnesota, Tobacco Research Programs, Minneapolis, MN, United States; University of Minnesota, Department of Psychiatry, Minneapolis, MN, United States. Electronic address: hatsu001@umn.edu.AbstractBACKGROUND: When switching from usual brand cigarettes, very low nicotine content (VLNC) cigarettes lead to a reduction in the number of cigarettes smoked, toxicant exposure, withdrawal symptoms and dependence. One area that has been relatively unexplored is what factors might moderate the effects of VLNC cigarettes. This exploratory analysis focuses on sex differences in responses to VLNC cigarettes and nicotine replacement therapy.
- Addictive behaviors.Addict Behav.2014 Jul;39(7):1197-204. doi: 10.1016/j.addbeh.2014.03.021. Epub 2014 Mar 30.
- BACKGROUND: When switching from usual brand cigarettes, very low nicotine content (VLNC) cigarettes lead to a reduction in the number of cigarettes smoked, toxicant exposure, withdrawal symptoms and dependence. One area that has been relatively unexplored is what factors might moderate the effects o
- PMID 24746485
Japanese Journal
- タンパク質の細胞内局在を操る小分子リガンド
- YAKUGAKU ZASSHI 136(1), 9-16, 2016
- NAID 130005115187
- Unexplored Reactivity of N-Alkyl Unsaturated Imines: A Simple Procedure for Producing Optically Active 1,3-Diamines via a Stereocontrolled Formal [4+2] and [4+2+2] Iminocycloaddition
- Bulletin of the Chemical Society of Japan advpub(0), 2016
- NAID 130005112198
- GaN系未開拓波長QCLの進展 (電子デバイス)
- 電子情報通信学会技術研究報告 = IEICE technical report : 信学技報 115(387), 31-35, 2015-12-21
- NAID 40020701434
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