- 同
- ampicillin-sulbactam
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/09/04 11:33:54」(JST)
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Ampicillin/sulbactam
Combination of |
Ampicillin |
Penicillin antibiotic |
Sulbactam |
Beta-lactamase inhibitor |
Clinical data |
MedlinePlus |
a693021 |
Pregnancy cat. |
? |
Legal status |
? |
Identifiers |
ATC code |
J01CR01 |
PubChem |
CID 656676 |
ChemSpider |
10482157 Y |
Y (what is this?) (verify)
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Ampicillin/sulbactam is a combination of the common penicillin-derived antibiotic ampicillin and sulbactam, an inhibitor of bacterial beta-lactamase. Two different forms of the drug exist. The first, developed in 1987 and marketed in the United States under the tradename Unasyn, is an intravenous antibiotic. The second, an oral form called sultamicillin, is marketed under the trade name Ampictam outside of the United States. Ampicillin/sulbactam is used to treat infections caused by bacteria resistant to beta-lactam antibiotics. Sulbactam blocks the enzyme which breaks down ampicillin and thereby allows ampicillin to attack and kill the bacteria.
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Skeletal formula of ampicillin |
Skeletal formula of sulbactam |
Skeletal formula of sultamicillin, highlighting ampicillin in blue and sulbactam in orange |
Ampicillin/sulbactam is also used when the cause of an infection is not known (empiric therapy). Intra-abdominal infections, skin infections, pneumonia, and gynecologic infections. It is active against a wide range of bacterial groups, including Staphylococcus aureus, Enterobacteriaceae, and anaerobic bacteria. Importantly, it is not active against Pseudomonas aeruginosa and should not be used alone when infection with this organism is suspected or known.
Synonyms
- Unasyn (USA)
- Subacillin (Taiwan)
- Sultamicillin
Antibacterials: cell envelope antibiotics (J01C-J01D)
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Intracellular |
- inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
- DADAL/AR inhibitors (Cycloserine)
- bactoprenol inhibitors (Bacitracin)
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Glycopeptide |
- inhibit PG chain elongation: Vancomycin# (Oritavancin
- Telavancin)
- Teicoplanin (Dalbavancin)
- Ramoplanin
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β-lactams/
(inhibit PBP
cross-links) |
Penicillins
(penams)
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Extended sp.
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- aminopenicillins: Amoxicillin#
- Ampicillin# (Pivampicillin
- Hetacillin
- Bacampicillin
- Metampicillin
- Talampicillin)
- Epicillin
- carboxypenicillins: Carbenicillin (Carindacillin)
- Ticarcillin
- Temocillin
- ureidopenicillins: Azlocillin
- Piperacillin
- Mezlocillin
- other: Mecillinam (Pivmecillinam)
- Sulbenicillin
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Narrow sp.
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β-lactamase sensitive
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- Benzylpenicillin (G)#: Clometocillin
- Benzathine benzylpenicillin#
- Procaine benzylpenicillin#
- Azidocillin
- Penamecillin
- Phenoxymethylpenicillin (V)#: Propicillin
- Benzathine phenoxymethylpenicillin
- Pheneticillin
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β-lactamase resistant
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- Cloxacillin# (Dicloxacillin
- Flucloxacillin)
- Oxacillin
- Meticillin
- Nafcillin
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Penems
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Carbapenems
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- Biapenem
- Ertapenem
- antipseudomonal (Doripenem
- Imipenem
- Meropenem)
- Panipenem
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Cephalosporins/Cephamycins
(cephems)
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1st (PEcK)
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- Cefazolin#
- Cefacetrile
- Cefadroxil
- Cefalexin
- Cefaloglycin
- Cefalonium
- Cefaloridine
- Cefalotin
- Cefapirin
- Cefatrizine
- Cefazedone
- Cefazaflur
- Cefradine
- Cefroxadine
- Ceftezole
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2nd (HEN)
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- Cefaclor
- Cefamandole
- Cefminox
- Cefonicid
- Ceforanide
- Cefotiam
- Cefprozil
- Cefbuperazone
- Cefuroxime
- Cefuzonam
- cephamycin (Cefoxitin
- Cefotetan
- Cefmetazole)
- carbacephem (Loracarbef)
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3rd
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- Cefixime#
- Ceftriaxone#
- antipseudomonal (Ceftazidime#
- Cefoperazone)
- Cefcapene
- Cefdaloxime
- Cefdinir
- Cefditoren
- Cefetamet
- Cefmenoxime
- Cefodizime
- Cefotaxime
- Cefpimizole
- Cefpiramide
- Cefpodoxime
- Cefsulodin
- Cefteram
- Ceftibuten
- Ceftiolene
- Ceftizoxime
- oxacephem (Flomoxef
- Latamoxef ‡)
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4th (antips-)
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- Cefepime
- Cefozopran
- Cefpirome
- Cefquinome
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5th
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- Ceftobiprole
- Ceftaroline fosamil
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Veterinary
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- Ceftiofur
- Cefquinome
- Cefovecin
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Monobactams
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- Aztreonam
- Tigemonam
- Carumonam
- Nocardicin A
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β-lactamase inh.
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- penam (Sulbactam
- Tazobactam)
- clavam (Clavulanic acid)
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Combinations
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- Amoxicillin/clavulanic acid#
- Imipenem/cilastatin#
- Ampicillin/flucloxacillin
- Ampicillin/sulbactam (Sultamicillin)
- Piperacillin/tazobactam
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Other |
- polymyxins/detergent (Colistin
- Polymyxin B)
- depolarizing (Daptomycin)
- hydrolyze NAM-NAG (Lysozyme)
- Gramicidin
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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gr+f/gr+a(t)/gr-p(c)/gr-o
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UpToDate Contents
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English Journal
- Prospective study on antimicrobial prophylaxis in total hip arthroplasty.
- Yuasa T1, Yamakawa J, Maezawa K, Kaneko K.
- European journal of orthopaedic surgery & traumatology : orthopédie traumatologie.Eur J Orthop Surg Traumatol.2015 May;25(4):737-40. doi: 10.1007/s00590-014-1540-y. Epub 2014 Sep 21.
- AIMS AND BACKGROUND: Prophylactic use of antibiotics against the pathogens likely to contaminate the procedure is considered beneficial to prevent surgical site infections. We asked that an increase in the effective blood concentration by increasing the administration dose immediately before the ope
- PMID 25240428
- The effectiveness of Tualang honey in reducing post-tonsillectomy pain.
- Abdullah B1, Lazim NM, Salim R.
- Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat.Kulak Burun Bogaz Ihtis Derg.2015 May-Jun;25(3):137-43. doi: 10.5606/kbbihtisas.2015.00008.
- OBJECTIVES: This study aims to evaluate the effectiveness of Tualang honey in reducing post-tonsillectomy pain.PATIENTS AND METHODS: The study included 63 patients (31 males, 32 females; mean age 10±4.16 years; range 3 to 18 years) who were planned to undergo tonsillectomy. Patients were randomized
- PMID 26050853
- Efficacy and safety of intravenous sulbactam/ampicillin 3 g 4 times daily in Japanese adults with moderate to severe community-acquired pneumonia: a multicenter, open-label, uncontrolled study.
- Kohno S1, Tateda K2, Mikamo H3, Kadota J4, Niki Y5, Itamura R6.
- Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.J Infect Chemother.2015 Mar;21(3):182-8. doi: 10.1016/j.jiac.2014.11.006. Epub 2014 Nov 20.
- Although sulbactam/ampicillin (SBT/ABPC) 3 g 4 times daily (QID) is widely used worldwide for patients with moderate to severe community-acquired pneumonia (CAP), the 3 g QID regimen was not available in Japan. In fact, there has been no evidence from a formal clinical study regarding the efficacy a
- PMID 25533886
Japanese Journal
- ウサギ耳介静脈を用いた静脈内投与抗菌剤の溶解量変更に伴う血管障害性に関する研究
- 大井 一弥,新井 純一,君塚 弘行,上田 秀雄,森本 雍憲
- 医療薬学 32(7), 710-713, 2006-07-10
- … We continuously injected 9 antimicrobial drugs (Viccillin^[○!R], Penicillin^[○!R], Unasyn-S^[○!R], Pansporin^[○!R], Cefmetazon^[○!R], Rocephin^[○!R], Sulperazon^[○!R], Flumarin^[○!R], Fosmicin-S^[○!R]) intravenously into the rabbit pinna vein. …
- NAID 110004740990
- 口腔外科領域の感染症に対するトシル酸スルタミシリン (SBTPC, ユナシン<SUP>®</SUP>) の臨床的検討
- 伊藤 暖果,高井 克憙,今井 隆生,石原 朗,加藤 久喜,金 度完,山下 敏康,中山 和久,吉田 憲司,深谷 昌彦,山田 史郎,神野 卓三,富田 陽二,稲本 浩,藤本 毅
- 日本口腔外科学会雑誌 35(12), 2979-2987, 1989
- … study of Sultamicillin (SBTPC, Unasyn<SUP>®</SUP>) in infections in the field of oral surgery was carried out.Sultamicillin was orally given in a daily dose of 1, 125 mg (375 mg × 3 times) to 70 patients with two type of infections (41 ostitis of the jaws, 29 pericoronitis).<BR>The following results were obtained.The clinical effects obtained by subjective judgement were excellent in 34 cases, good in 29, fair in 2 and poor in 2.The clinical effects obtained by scoring judgement were excellent in 31 cases, good in 35, poor …
- NAID 130001356999
Related Links
- Unasyn official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.
- Learn about the prescription medication Unasyn (Ampicillin and Sulbactam), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling.
Related Pictures