tyrosine 3-monooxygenase

出典: meddic

チロシン水酸化酵素

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/01/18 16:39:29」(JST)

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英文文献

  • Reference gene for primary culture of prostate cancer cells.
  • Souza AF, Brum IS, Neto BS, Berger M, Branchini G.SourceLaboratório de Biologia Molecular Endócrina e Tumoral, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite 500, 2º andar, laboratório 09, Porto Alegre, RS, 90050-170, Brazil.
  • Molecular biology reports.Mol Biol Rep.2013 Apr;40(4):2955-62. doi: 10.1007/s11033-012-2366-5. Epub 2012 Dec 27.
  • Selection of reference genes to normalize mRNA levels between samples is critical for gene expression studies because their expression can vary depending on the tissues or cells used and the experimental conditions. We performed ten cell cultures from samples of prostate cancer. Cells were divided i
  • PMID 23269617
  • Exposure to the polybrominated diphenyl ether mixture DE-71 damages the nigrostriatal dopamine system: role of dopamine handling in neurotoxicity.
  • Bradner JM, Suragh TA, Wilson WW, Lazo CR, Stout KA, Kim HM, Wang MZ, Walker DI, Pennell KD, Richardson JR, Miller GW, Caudle WM.SourceDepartment of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322-3090, USA. joshua.m.bradner@emory.edu
  • Experimental neurology.Exp Neurol.2013 Mar;241:138-47. doi: 10.1016/j.expneurol.2012.12.013. Epub 2012 Dec 31.
  • In the last several decades polybrominated diphenyl ethers (PBDEs) have replaced the previously banned polychlorinated biphenyls (PCBs) in multiple flame retardant utilities. As epidemiological and laboratory studies have suggested PCBs as a risk factor for Parkinson's disease (PD), the similarities
  • PMID 23287494
  • Association of monoamine-synthesizing genes with the depression tendency and personality in chronic fatigue syndrome patients.
  • Fukuda S, Horiguchi M, Yamaguti K, Nakatomi Y, Kuratsune H, Ichinose H, Watanabe Y.SourceDepartment of Medical Science on Fatigue, Osaka City University, Graduate School of Medicine, Osaka, Japan.
  • Life sciences.Life Sci.2013 Feb 27;92(3):183-6. doi: 10.1016/j.lfs.2012.11.016. Epub 2012 Dec 13.
  • AIMS: Tyrosine hydroxylase (TH) and GTP cyclohydrolase I (GCH) are the rate-limiting enzymes for the biosynthesis of catecholamines and tetrahydrobiopterin (BH4), respectively. Since catecholamines and BH4 are thought to be involved in the pathophysiology of CFS, we explored the genetic factors that
  • PMID 23246742

和文文献

  • Methylmercury can induce Parkinson's-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells
  • Chronic high-dose haloperidol has qualitatively similar effects to risperidone and clozapine on immediate-early gene and tyrosine hydroxylase expression in the rat locus coeruleus but not medial prefrontal cortex
  • Neuroscience research : the official journal of the Japan Neuroscience Society 57(1), 17-28, 2007-01-01
  • NAID 10021187949
  • The catecholamine system in health and disease -Relation to tyrosine 3-monooxygenase and other catecholamine-synthesizing enzymes-:—Relation to tyrosine 3-monooxygenase and other catecholamine-synthesizing enzymes—

関連リンク

Tyrosine 3-monooxygenase (TH) Aromatic-L-amino-acid decarboxylase (DDC) This subpathway is part of the pathway dopamine biosynthesis, which is itself part of Catecholamine biosynthesis. View all proteins of this organism . ...
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and ...

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★リンクテーブル★
リンク元カテコールアミン」「チロシン水酸化酵素」「チロシン3-水酸化酵素
関連記事tyrosine」「monooxygenases」「monooxygenase

カテコールアミン」

  [★]

catecholamine catecholamines CA
カテコラミン
副腎髄質ホルモン
  • カテコールでかつアミンを持つ構造

Wikipedia

生合成

チロシン tyrosine
 (フェニル基の3位にOHを導入) :律速酵素
 -チロシン 3-モノオキシゲナーゼ tyrosine 3-monooxygenase, チロシン水酸化酵素 tyrosine hydroxylase
 ←{H4biopterin}
 →{H2biopterin}
L-ドーパ L-dopa
 (アミノ酸から脱炭酸)
 -芳香族アミノ酸デカルボキシラーゼ dopa decarboxylase + {ピリドキサル5-リン酸(VB6)}
 →CO2
ドパミン dopamine
 (β位の炭素にOHを導入)
 -ドーパミン β-モノオキシゲナーゼ dopamine β-monoxygenase, dopamine β-odidase
 ←O2 + ビタミンC(アスコルビン酸)
 →H2O + デヒドロアスコルビン酸
ノルアドレナリン norepinephrine
 (アミノ基にメチル基を転移)
 -フェニルエタノールアミン N-メチルトランスフェラーゼ phenylethanolamine N-methyl transferase
 ←S-アデノシルメチオニン S-adenosylmethionineS-アデノシルホモシステイン S-adenosylhemocysteine
アドレナリン epinephrine

分解

分解産物

ドパミン
dopamine
---→ ジヒドロキシフェニル酢酸
3,4-dihydroxyphenylacetic acid
DOPAC
---→ ホモバニリン酸
homovanillic acid
HVA

MAO
COMT
     


       
ノルエピネフリン
norepinephrine
---→ バニリルマンデリン酸
vanillylmandelic acid
VMA
       ・
メトキシヒドロキシフェニルグリコール
methoxyhydroxyphenylglycol
MHPG
   


MAO
COMT
   
エピネフリン
epinephrine
---→    
  MAO
COMT
   

薬理作用

昇圧作用






チロシン水酸化酵素」

  [★]

tyrosine 3-hydroxylase, TH, tyrosine 3-monooxygenase
チロシンヒドロキシラーゼ
カテコラミン
[show details]



チロシン3-水酸化酵素」

  [★]

tyrosine 3-hydroxylase TH
チロシン3-ヒドロキシラーゼチロシン3-モノオキシゲナーゼ tyrosine 3-monooxygenase


tyrosine」

  [★] チロシン

WordNet   license wordnet

「an amino acid found in most proteins; a precursor of several hormones」


monooxygenases」

  [★]

See also Cytochrome P450 system


monooxygenase」

  [★] モノオキシゲナーゼ




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