WordNet
- write by means of a keyboard with types; "type the acceptance letter, please" (同)typewrite
- a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper; "he dropped a case of type, so they made him pick them up"
- (biology) the taxonomic group whose characteristics are used to define the next higher taxon
- a subdivision of a particular kind of thing; "what type of sculpture do you prefer?"
- all of the tokens of the same symbol; "the word `element contains five different types of character"
- printed characters; "small type is hard to read"
- identify as belonging to a certain type; "Such people can practically be typed" (同)typecast
- the 9th letter of the Roman alphabet (同)i
- writing done with a typewriter (同)typewriting
PrepTutorEJDIC
- 〈C〉(…の)『型』,タイプ,類型,種類(kind)《+of+名》 / 〈C〉(その種類の特質を最もよく表している)『典型』,手本,模範《+of+名》 / 〈U〉《集合的に》活字;〈C〉(1個の)活字 / 〈U〉(印刷された)字体,活字 / 〈C〉(貨幣・メダルなどの)模様,図柄 / 〈C〉血液型(blood group) / …‘を'タイプに打つ / (…として)…‘を'分類する《+名+as+名(doing)》 / …‘の'型を決める / タイプライターを打つ
- 『私は』私が
- iodineの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/13 19:58:50」(JST)
[Wiki en表示]
| Type I pneumocyte |
| Code |
TH H3.05.02.0.0028 |
Type I pneumocyte cells (also called type I alveolar cells or squamous alveolar cells) are extremely attenuated cells that line the alveolar surfaces of the lungs. They cover 97% of the alveolar surface, with type II pneumocytes covering the remainder. These cells are so thin (sometimes only 25 nm) that the electron microscope was needed to prove that all alveoli are covered with an epithelial lining. It is important that these cells are thin so that gas exchange between the alveoli and blood can occur easily. Their main role is to provide a barrier of minimal thickness that is readily permeable to gases such as oxygen and carbon dioxide.
Description[edit]
Organelles of Type 1 pneumocyte cells such as the ER, Golgi apparatus, and mitochondria are clustered around the nucleus. This leaves large areas of cytoplasm virtually free of organelles and reduces the thickness of the cell, thus reducing the thickness of the blood-air barrier. The cytoplasm in the thin portion contains pinocytotic vesicles, which may play a role in the turnover of surfactant and the removal of small particulate contaminants from the outer surface. (However, type 2 pneumocytes are primarily responsible for secretion of surfactant). In addition to desmosomes, all type I pneumocyte cells have occluding junctions that prevent the leakage of tissue fluid into the alveolar air space.
Type I pneumocytes are unable to replicate and are susceptible to toxic insults. In the event of damage, Type II cells can proliferate and/or differentiate into type I cells to compensate.
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Anatomy: Lower RT respiratory system (TA A06.3–5, TH H3.05.02, GA 11.1084)
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| TB tree |
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Trachea
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- Tracheal rings
- Annular ligaments of trachea
- Carina
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Bronchus
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- main bronchus
- lobar/secondary bronchi
- segmental/tertiary bronchi
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| Lungs |
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General
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- Left lung/Right lung
- Base/Apex
- Root/Hilum
- Superior lobe
- Lingula of left lung/Middle lobe of right lung
- Inferior lobe
- borders: Anterior border
- Posterior border
- Inferior border
- surfaces: Costal surface
- Mediastinal surface
- Diaphragmatic surface
- fissures: Oblique fissure
- Horizontal fissure
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BP segment
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- Bronchiole: Conducting zone (Terminal bronchiole)
- Respiratory zone (Respiratory bronchiole
- Alveolar duct
- Alveolus
- Blood-air barrier)
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Cells
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- Pneumocyte (Type I pneumocyte
- Type II pneumocyte)
- Clara cell
- Goblet cell
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anat (n, x, l, c)/phys/devp
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noco (c, p)/cong/tumr, sysi/epon, injr
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proc, drug (R1/2/3/5/6/7)
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Human cell types / list derived primarily from endoderm
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| Foregut |
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Respiratory
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Pneumocyte (Type I pneumocyte, Type II pneumocyte) · Clara cell · Goblet cell
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Digestive
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Stomach
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enteroendocrine: G cell · D cell · ECL cell
exocrine: Gastric chief cell · Parietal cell
Foveolar cell
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Intestine
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enteroendocrine: K cell · S cell · D cell · I cell
Goblet cell · Paneth cell
Enterocyte (Microfold cell)
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Liver
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Hepatocyte · Hepatic stellate cell · (Kupffer cell from mesoderm)
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Gallbladder
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Cholecystocyte
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Exocrine pancreas
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Centroacinar cell · Pancreatic stellate cell
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Endocrine
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endocrine pancreas (alpha cell, beta cell, delta cell, F cell(PP cell), epsilon cell)
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| Pharyngeal pouch |
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Endocrine
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thyroid (Follicular cell) · parathyroid (Parathyroid chief cell, Oxyphil cell)
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| Hindgut/cloaca |
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Urogenital
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Urothelial cells
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UpToDate Contents
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English Journal
- MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.
- Fell MJ1, Mirescu C2, Basu K2, Cheewatrakoolpong B2, DeMong DE2, Ellis JM2, Hyde LA2, Lin Y2, Markgraf CG2, Mei H2, Miller M2, Poulet FM2, Scott JD2, Smith MD2, Yin Z2, Zhou X2, Parker EM2, Kennedy ME2, Morrow JA2.
- The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2015 Dec;355(3):397-409. doi: 10.1124/jpet.115.227587. Epub 2015 Sep 25.
- Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of familial and sporadic Parkinson's disease (PD). That the most prevalent mutation, G2019S, leads to increased kinase activity has led to a concerted effort to identify LRRK2 kinase inhibitors as a potentia
- PMID 26407721
- Preclinical Development of an Anti-NaPi2b (SLC34A2) Antibody-Drug Conjugate as a Therapeutic for Non-Small Cell Lung and Ovarian Cancers.
- Lin K1, Rubinfeld B1, Zhang C1, Firestein R1, Harstad E1, Roth L1, Tsai SP1, Schutten M1, Xu K1, Hristopoulos M1, Polakis P2.
- Clinical cancer research : an official journal of the American Association for Cancer Research.Clin Cancer Res.2015 Nov 15;21(22):5139-50. doi: 10.1158/1078-0432.CCR-14-3383. Epub 2015 Jul 8.
- PURPOSE: Antibody-drug conjugates (ADC) selectively deliver a cytotoxic drug to cells expressing an accessible antigenic target. Here, we have appended monomethyl auristatin E (MMAE) to an antibody recognizing the SLC34A2 gene product NaPi2b, the type II sodium-phosphate cotransporter, which is high
- PMID 26156394
- CaMKII inhibition in Type II pneumocytes protects from bleomycin-induced pulmonary fibrosis by preventing Ca2+-dependent apoptosis.
- Winters CJ1, Koval OM2, Murthy S1, Allamargot C1, Sebag SC1, Paschke JD1, Jaffer OA3, Carter AB2, Grumbach IM4.
- American journal of physiology. Lung cellular and molecular physiology.Am J Physiol Lung Cell Mol Physiol.2015 Nov 6:ajplung.00132.2015. doi: 10.1152/ajplung.00132.2015. [Epub ahead of print]
- Purpose/Aim of the study-The Calcium and calmodulin-dependent kinase II (CaMKII) translates increases in intracellular Ca2+ into downstream signaling events. Its function in pulmonary pathologies remains largely unknown. CaMKII is a well-known mediator of apoptosis and regulator of ER Ca2+. Endoplas
- PMID 26545899
Japanese Journal
- A Patient who Survived Primary Seasonal Influenza Viral Pneumonia: Histologic Findings Obtained via Bronchoscopy
- Ishiguro Takashi,Takayanagi Noboru,Shimizu Yoshihiko,Kagiyama Naho,Yanagisawa Tsutomu,Sugita Yutaka
- Internal Medicine 52(24), 2795-2800, 2013
- … A right lower lobe transbronchial lung biopsy revealed type II pneumocyte metaplasia, acute and chronic interstitial infiltrates and alveolar organization without hyaline membranes or fibrin thrombi in the vascular lumen. …
- NAID 130003383760
- 症例 微小結節性肺胞上皮過形成を合併した腎血管筋脂肪腫
- A Case of Papillary Adenoma of the Lung
- 若林 綾,冨田 尚吾,土屋 裕,臼田 亮介,鈴木 隆,國分 二三男
- 肺癌 52(6), 878-883, 2012
- … Electron microscopy revealed that the tumor cells contained lamellar inclusion bodies in their cytoplasm that were characteristic of type II pneumocytes. … These findings led to a diagnosis of papillary adenoma of the lung with pneumocytic differentiation into type II alveolar lining cells. …
- NAID 130003314993
Related Links
- Definition of type I pneumocyte in the Medical Dictionary. type I pneumocyte explanation. Information about type I pneumocyte in Free online English dictionary. What is type I pneumocyte? Meaning of type I pneumocyte medical ...
- ...capillaries are lined by flat endothelial cells with thin cytoplasmic extensions. The interalveolar septum is covered on both sides by the alveolar epithelial cells. A thin, squamous cell type, the type I pneumocyte, covers between 92 ...
★リンクテーブル★
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- 英
- alveolar epithelial type I cell alveolar type I cell、alveolar type I epithelial cell
- 同
- I型肺胞細胞 type I pneumocyte、小肺胞細胞 small alveolar cell、扁平肺胞細胞 squamous alveolar cell、呼吸肺胞細胞 respiratory epithelial cell、肺上皮細胞 pulmonary epithelial cell
- 関
- 肺胞上皮細胞、II型肺胞上皮細胞
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- (windows)ファイル内容表示(linux -> cat])
- ex. type report_20111118.jp.htm | php a.php > report_20111118.jp.jp.jp.html
- 関
- form、mode、pattern、type specimen、typed
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- 関
- form、mode、pattern、type
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