I型アレルギー
WordNet
- write by means of a keyboard with types; "type the acceptance letter, please" (同)typewrite
- a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper; "he dropped a case of type, so they made him pick them up"
- (biology) the taxonomic group whose characteristics are used to define the next higher taxon
- a subdivision of a particular kind of thing; "what type of sculpture do you prefer?"
- all of the tokens of the same symbol; "the word `element contains five different types of character"
- printed characters; "small type is hard to read"
- identify as belonging to a certain type; "Such people can practically be typed" (同)typecast
- the 9th letter of the Roman alphabet (同)i
- pathological sensitivity
- extreme sensitivity
- writing done with a typewriter (同)typewriting
PrepTutorEJDIC
- 〈C〉(…の)『型』,タイプ,類型,種類(kind)《+of+名》 / 〈C〉(その種類の特質を最もよく表している)『典型』,手本,模範《+of+名》 / 〈U〉《集合的に》活字;〈C〉(1個の)活字 / 〈U〉(印刷された)字体,活字 / 〈C〉(貨幣・メダルなどの)模様,図柄 / 〈C〉血液型(blood group) / …‘を'タイプに打つ / (…として)…‘を'分類する《+名+as+名(doing)》 / …‘の'型を決める / タイプライターを打つ
- 『私は』私が
- iodineの化学記号
- 過敏,過敏症
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/28 13:28:33」(JST)
[Wiki en表示]
| Type I hypersensitivity |
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SEM of miscellaneous plant pollens. Pollens are very common allergens.
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| Classification and external resources |
| MeSH |
D006969 |
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[edit on Wikidata]
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Type I hypersensitivity (or immediate hypersensitivity) is an allergic reaction provoked by reexposure to a specific type of antigen referred to as an allergen.[1] Type I is not to be confused with Type II, Type III, or Type IV hypersensitivities.
Exposure may be by ingestion, inhalation, injection, or direct contact.
Contents
- 1 Pathophysiology
- 2 Treatment and prognosis
- 3 Examples
- 4 See also
- 5 References
- 6 External links
Pathophysiology
In type 1 hypersensitivity, B-cells are stimulated (by CD4+TH2 cells) to produce IgE antibodies specific to an antigen. The difference between a normal infectious immune response and a type 1 hypersensitivity response is that in type 1 hypersensitivity the antibody is IgE instead of IgA, IgG, or IgM. During sensitisation, the IgE antibodies bind to Fcε receptors on the surface of tissue mast cells and blood basophils.[2] Mast cells and basophils coated by IgE antibodies are "sensitised." Later exposure to the same allergen cross-links the bound IgE on sensitised cells, resulting in degranulation and the secretion of pharmacologically active mediators such as histamine, leukotriene (LTC4 and LTD4), and prostaglandin that act on the surrounding tissues. The principal effects of these products are vasodilation and smooth-muscle contraction.
Type 1 hypersensitivity can be further classified into an immediate and late-phase reaction. The immediate hypersensitivity reaction occurs minutes after exposure and includes release of vasoactive amines and lipid mediators, whereas the late-phase reaction occurs 2–4 hours after exposure and includes the release of cytokines.[3]
Overview of mediators released by mast cells in type 1 hypersensitivity, and their actions:
| Vasodilation and increased permeability |
- Histamine
- PAF
- Leukotriene C4, D4 and E4
- Prostaglandin D2
- Neutral proteases
|
| Smooth muscle spasm |
- Histamine
- PAF
- Leukotriene C4, D4 and E4
- Prostaglandin
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| Leukocyte extravasation |
- Cytokines (e.g. chemokines and TNF)
- Leukotriene B4
- Chemotactic factors for neutrophils and eosinophils
|
| Unless otherwise specified, the reference for this table is:[4] |
The reaction may be either local or systemic. Symptoms vary from mild irritation to sudden death from anaphylactic shock.
Treatment and prognosis
Treatment usually involves adrenaline (epinephrine), antihistamines, and corticosteroids. If the entire body gets involved, then anaphylaxis can take place, which is an acute, systemic reaction that can prove fatal.
Examples
Some examples:
- Allergic asthma
- Allergic conjunctivitis
- Allergic rhinitis ("hay fever")
- Anaphylaxis
- Angioedema
- Urticaria (hives)
- Eosinophilia
- Penicillin allergy
- Cephalosporin allergy
- Food allergy
- Sweet itch
See also
- Type II hypersensitivity
- Type III hypersensitivity
- Type IV hypersensitivity
- Type V hypersensitivity
References
- ^ med/1101 at eMedicine
- ^ "The Adaptive Immune System: Type I Immediate Hypersensitivity". Retrieved 2008-09-22.
- ^ Shiv Pillai MD; Abul K. Abbas MBBS; Andrew Wilson (2011). Cellular and Molecular Immunology: with STUDENT CONSULT Online Access. Philadelphia: Saunders. ISBN 1-4377-1528-1.
- ^ Table 5-2 in:Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.
External links
- Type I hypersensitivity (Flash Animation)
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Hypersensitivity and autoimmune diseases (279.5–6)
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Type I/allergy/atopy
(IgE) |
| Foreign |
- Atopic eczema
- Allergic urticaria
- Allergic rhinitis (Hay fever)
- Allergic asthma
- Anaphylaxis
- Food allergy
- common allergies include: Milk
- Egg
- Peanut
- Tree nut
- Seafood
- Soy
- Wheat
- Penicillin allergy
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|
| Autoimmune |
|
|
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Type II/ADCC
|
| Foreign |
- Hemolytic disease of the newborn
|
|
| Autoimmune |
| Cytotoxic |
- Autoimmune hemolytic anemia
- Immune thrombocytopenic purpura
- Bullous pemphigoid
- Pemphigus vulgaris
- Rheumatic fever
- Goodpasture's syndrome
- Guillain–Barré syndrome
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| "Type V"/receptor |
- Graves' disease
- Myasthenia gravis
- Pernicious anemia
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Type III
(Immune complex) |
| Foreign |
- Henoch–Schönlein purpura
- Hypersensitivity vasculitis
- Reactive arthritis
- Farmer's lung
- Post-streptococcal glomerulonephritis
- Serum sickness
- Arthus reaction
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| Autoimmune |
- Systemic lupus erythematosus
- Subacute bacterial endocarditis
- Rheumatoid arthritis
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Type IV/cell-mediated
(T cells) |
| Foreign |
- Allergic contact dermatitis
- Mantoux test
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| Autoimmune |
- Diabetes mellitus type 1
- Hashimoto's thyroiditis
- Multiple sclerosis
- Coeliac disease
- Giant-cell arteritis
- Postorgasmic illness syndrome
- Reactive arthritis
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| GVHD |
- Transfusion-associated graft versus host disease
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Unknown/
multiple |
| Foreign |
- Hypersensitivity pneumonitis
- Allergic bronchopulmonary aspergillosis
- Transplant rejection
- Latex allergy (I+IV)
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| Autoimmune |
- Sjögren's syndrome
- Autoimmune hepatitis
- Autoimmune polyendocrine syndrome
- Autoimmune adrenalitis
- Systemic autoimmune disease
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UpToDate Contents
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English Journal
- Pretreatment with glycomacropeptide reduces allergen sensitization, alleviates immediate cutaneous hypersensitivity and protects from anaphylaxis.
- Jiménez M, Chávez NA, Salinas E.SourceDepartment of Microbiology Department of Biochemical Engineering, Basic Science Center, Autonomous University of Aguascalientes, Aguascalientes, Mexico.
- Clinical and experimental immunology.Clin Exp Immunol.2012 Oct;170(1):18-27. doi: 10.1111/j.1365-2249.2012.04631.x.
- Allergic disorders are characterized by the involvement of allergen-specific immunoglobulin (Ig)E antibodies and T helper type 2 (Th2) cells. The search for new therapies for allergic diseases has been the primary focus of interest for many investigators in recent years. Glycomacropeptide (GMP) is a
- PMID 22943197
- CɛmX peptide-carrying HBcAg virus-like particles induced antibodies that down-regulate mIgE-B lymphocytes.
- Lin CJ, Chen NY, Chen JB, Lu CS, Hung AF, Shiung YY, Wu PC, Pan RL, Chang TW.SourceInstitute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 300, Taiwan.
- Molecular immunology.Mol Immunol.2012 Oct;52(3-4):190-9. Epub 2012 Jun 15.
- Type-I hypersensitivity reactions play a critical role in the pathogenesis of various allergic diseases. The successful development of the anti-IgE antibody, omalizumab, has validated IgE as an effective therapeutic target for the treatment of various IgE-mediated allergic diseases. Two research gro
- PMID 22706073
Japanese Journal
- Novel concept of iSALT (inducible skin-associated lymphoid tissue) in the elicitation of allergic contact dermatitis
- 症例報告 市販点眼薬の添加物であるクロルヘキシジングルコン酸塩による即時型アレルギーの1例
- 臨床皮膚科 = Japanese journal of clinical dermatology 69(13), 993-996, 2015-12
- NAID 40020660173
- 口腔粘膜における実験的な遅延型過敏反応とサイトカインの誘導
- 日本口腔内科学会雑誌 = Journal of Japanese Society of Oral Medicine 21(1), 1-8, 2015-06
- NAID 40020575482
Related Links
- What is type I hypersensitivity? Type I hypersensitivity, or sometimes IgE-mediated hypersensitivity or immediate hypersensitivity, is a type of immune reaction in which tissue is damaged due to IgE ...
- This video includes a beautiful animation that shows clearly all of the steps involved in the early (primary) and late (secondary) responses from a type I hypersensitivity reaction. We hope you enjoy the ...
★リンクテーブル★
[★]
- 英
- type I allergic reaction, type I hypersensitivity
- 同
- I型アレルギー反応、即時型アレルギー反応 immediate allergic reaction、IgE依存型アレルギー反応 IgE-dependent allergic reaction、即時型過敏反応 immediate-type hypersensitivity immediate type hypersensitivity
- 関
- アレルギー
概念
免疫反応の主体
抗原
エフェクター機構
アレルギー疾患の例
アレルゲン
検査方法
immediate reaction and late-phase reaction (IMM.571)
- 30分
- 肥満細胞からのヒスタミン・プロスタグランジンの放出、血管透過性を亢進させる物質の素早い合成による
- 8-12時間
- 肥満細胞が放出したchemokineにより白血球細胞が遊走してくることによる
[★]
- 英
- type I hypersensitivity
- 関
- 即時型過敏症、I型過敏症、IgE依存性過敏症、I型アレルギー反応、I型アレルギー
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I型アレルギー
- 関
- hypersensitivity reactions＆type I
[★]
- (windows)ファイル内容表示(linux -> cat])
- ex. type report_20111118.jp.htm | php a.php > report_20111118.jp.jp.jp.html
- 関
- form、mode、pattern、type specimen、typed
[★]
[★]
[★]
- 関
- form、mode、pattern、type
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