II型過敏性免疫反応
WordNet
- write by means of a keyboard with types; "type the acceptance letter, please" (同)typewrite
- a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper; "he dropped a case of type, so they made him pick them up"
- (biology) the taxonomic group whose characteristics are used to define the next higher taxon
- a subdivision of a particular kind of thing; "what type of sculpture do you prefer?"
- all of the tokens of the same symbol; "the word `element contains five different types of character"
- printed characters; "small type is hard to read"
- identify as belonging to a certain type; "Such people can practically be typed" (同)typecast
- (mechanics) the equal and opposite force that is produced when any force is applied to a body; "every action has an equal and opposite reaction"
- a response that reveals a persons feelings or attitude; "he was pleased by the audiences reaction to his performance"; "John feared his mothers reaction when she saw the broken lamp"
- a bodily process occurring due to the effect of some antecedent stimulus or agent; "a bad reaction to the medicine"; "his responses have slowed with age" (同)response
- doing something in opposition to another way of doing it that you dont like; "his style of painting was a reaction against cubism"
- an idea evoked by some experience; "his reaction to the news was to start planning what to do"
- extreme conservatism in political or social matters; "the forces of reaction carried the election"
- the 9th letter of the Roman alphabet (同)i
- pathological sensitivity
- extreme sensitivity
PrepTutorEJDIC
- 〈C〉(…の)『型』,タイプ,類型,種類(kind)《+of+名》 / 〈C〉(その種類の特質を最もよく表している)『典型』,手本,模範《+of+名》 / 〈U〉《集合的に》活字;〈C〉(1個の)活字 / 〈U〉(印刷された)字体,活字 / 〈C〉(貨幣・メダルなどの)模様,図柄 / 〈C〉血液型(blood group) / …‘を'タイプに打つ / (…として)…‘を'分類する《+名+as+名(doing)》 / …‘の'型を決める / タイプライターを打つ
- {名}(…に対する)『反応』《+『to』+『名』》 / 〈U〉(…に対する)(政治的・社会的な)『反動』,逆コース《+『against』+『名』》 / 〈U〉〈C〉化学反応,化学変化 / 〈U〉〈C〉(物理学で)反作用
- 『私は』私が
- iodineの化学記号
- 過敏,過敏症
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/13 20:46:13」(JST)
[Wiki en表示]
| Type II hypersensitivity |
| Classification and external resources |
| DiseasesDB |
33482 |
| MedlinePlus |
000821 |
| MeSH |
D001327 |
In type II hypersensitivity (or cytotoxic hypersensitivity)[1] the antibodies produced by the immune response bind to antigens on the patient's own cell surfaces. The antigens recognized in this way may either be intrinsic ("self" antigen, innately part of the patient's cells) or extrinsic (adsorbed onto the cells during exposure to some foreign antigen, possibly as part of infection with a pathogen). These cells are recognized by macrophages or dendritic cells, which act as antigen-presenting cells. This causes a B cell response, wherein antibodies are produced against the foreign antigen.
An example of type II hypersensitivity is the ABO blood incompatibility where the red blood cells have different antigens, causing them to be recognized as different; B cell proliferation will take place and antibodies to the foreign blood type are produced. IgG and IgM antibodies bind to these antigens to form complexes that activate the classical pathway of complement activation to eliminate cells presenting foreign antigens. That is, mediators of acute inflammation are generated at the site and membrane attack complexes cause cell lysis and death. The reaction takes hours to a day.
Type II reactions can affect healthy cells. Examples include Red blood cells in Haemolytic Anaemia, Acetylcholine receptors in Myasthenia Gravis, and TSH receptors in Grave's Disease.
Another example of type II hypersensitivity reaction is Goodpasture's syndrome where the basement membrane (containing collagen type IV) in the lung and kidney is attacked by one's own antibodies.[2]
Another form of type II hypersensitivity is called antibody-dependent cell-mediated cytotoxicity (ADCC). Here, cells exhibiting the foreign antigen are tagged with antibodies (IgG or IgM). These tagged cells are then recognised by natural killer cells (NK) and macrophages (recognised via IgG bound (via the Fc region) to the effector cell surface receptor, CD16 (FcγRIII)), which in turn kill these tagged cells.
See also
- Type I hypersensitivity
- Type III hypersensitivity
- Type IV hypersensitivity
- Type V hypersensitivity
References
- ^ "Hypersensitivity reactions".
- ^ Goodpasture Syndrome at eMedicine
|
Hypersensitivity and autoimmune diseases (279.5–6)
|
|
Type I/allergy/atopy
(IgE) |
| Foreign |
- Atopic eczema
- Allergic urticaria
- Allergic rhinitis (Hay fever)
- Allergic asthma
- Anaphylaxis
- Food allergy
- common allergies include: Milk
- Egg
- Peanut
- Tree nut
- Seafood
- Soy
- Wheat
- Penicillin allergy
|
|
| Autoimmune |
|
|
|
Type II/ADCC
|
| Foreign |
- Hemolytic disease of the newborn
|
|
| Autoimmune |
| Cytotoxic |
- Autoimmune hemolytic anemia
- Idiopathic thrombocytopenic purpura
- Bullous pemphigoid
- Pemphigus vulgaris
- Rheumatic fever
- Goodpasture's syndrome
- Guillain–Barré syndrome
|
|
| "Type V"/receptor |
- Graves' disease
- Myasthenia gravis
- Pernicious anemia
|
|
|
|
Type III
(Immune complex) |
| Foreign |
- Henoch–Schönlein purpura
- Hypersensitivity vasculitis
- Reactive arthritis
- Farmer's lung
- Post-streptococcal glomerulonephritis
- Serum sickness
- Arthus reaction
|
|
| Autoimmune |
- Systemic lupus erythematosus
- Subacute bacterial endocarditis
- Rheumatoid arthritis
|
|
|
Type IV/cell-mediated
(T cells) |
| Foreign |
- Allergic contact dermatitis
- Mantoux test
|
|
| Autoimmune |
- Diabetes mellitus type 1
- Hashimoto's thyroiditis
- Multiple sclerosis
- Coeliac disease
- Giant-cell arteritis
- Postorgasmic illness syndrome
- Reactive arthritis[1]
|
|
| GVHD |
- Transfusion-associated graft versus host disease
|
|
|
Unknown/
multiple |
| Foreign |
- Hypersensitivity pneumonitis
- Allergic bronchopulmonary aspergillosis
- Transplant rejection
- Latex allergy (I+IV)
|
|
| Autoimmune |
- Sjögren's syndrome
- Autoimmune hepatitis
- Autoimmune polyendocrine syndrome
- Autoimmune adrenalitis
- Systemic autoimmune disease
|
|
|
|
Index of the immune system
|
|
| Description |
- Physiology
- cells
- autoantigens
- autoantibodies
- complement
- surface antigens
- IG receptors
|
|
| Disease |
- Allergies
- Immunodeficiency
- Immunoproliferative immunoglobulin disorders
- Hypersensitivity and autoimmune disorders
- Neoplasms and cancer
|
|
| Treatment |
- Procedures
- Drugs
- antihistamines
- immunostimulants
- immunosuppressants
- monoclonal antibodies
|
|
|
- ^ Basic Pathology - Robbins et al - 9th edition
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Treatment with Chemotherapy and Dendritic Cells Pulsed with Multiple Wilms' Tumor 1 (WT1)-Specific MHC Class I/II-Restricted Epitopes for Pancreatic Cancer.
- Koido S1, Homma S2, Okamoto M3, Takakura K4, Mori M5, Yoshizaki S5, Tsukinaga S4, Odahara S4, Koyama S6, Imazu H6, Uchiyama K4, Kajihara M4, Arakawa H6, Misawa T7, Toyama Y7, Yanagisawa S7, Ikegami M8, Kan S2, Hayashi K2, Komita H2, Kamata Y2, Ito M2, Ishidao T5, Yusa S5, Shimodaira S9, Gong J10, Sugiyama H11, Ohkusa T4, Tajiri H4.
- Clinical cancer research : an official journal of the American Association for Cancer Research.Clin Cancer Res.2014 Aug 15;20(16):4228-39. doi: 10.1158/1078-0432.CCR-14-0314. Epub 2014 Jul 23.
- PURPOSE: We performed a phase I trial to investigate the safety, clinical responses, and Wilms' tumor 1 (WT1)-specific immune responses following treatment with dendritic cells (DC) pulsed with a mixture of three types of WT1 peptides, including both MHC class I and II-restricted epitopes, in combin
- PMID 25056373
- Activation of transient receptor potential vanilloid 2-expressing primary afferents stimulates synaptic transmission in the deep dorsal horn of the rat spinal cord and elicits mechanical hyperalgesia.
- Petitjean H1, Hugel S, Barthas F, Bohren Y, Barrot M, Yalcin I, Schlichter R.
- The European journal of neuroscience.Eur J Neurosci.2014 Aug 8. doi: 10.1111/ejn.12688. [Epub ahead of print]
- Probenecid, an agonist of transient receptor vanilloid (TRPV) type 2, was used to evaluate the effects of TRPV2 activation on excitatory and inhibitory synaptic transmission in the dorsal horn (DH) of the rat spinal cord and on nociceptive reflexes induced by thermal heat and mechanical stimuli. The
- PMID 25104469
- Suppression of collagen-induced arthritis with a serine proteinase inhibitor (serpin) derived from myxoma virus.
- Brahn E1, Lee S2, Lucas A3, McFadden G4, Macaulay C5.
- Clinical immunology (Orlando, Fla.).Clin Immunol.2014 Aug;153(2):254-63. doi: 10.1016/j.clim.2014.05.003. Epub 2014 May 17.
- Many viruses encode virulence factors to facilitate their own survival by modulating a host's inflammatory response. One of these factors, secreted from cells infected with myxoma virus, is the serine proteinase inhibitor (serpin) Serp-1. Because Serp-1 had demonstrated anti-inflammatory properties
- PMID 24845791
Japanese Journal
- The Effect of a Newly Synthesized Indazole Compound, TAS-3-124, on Experimental Autoimmune Disease(Pharmacology)
- Effect of (3,5,6-Trimethylpyrazin-2-yl)methyl 2-[4-(2-Methylpropyl)-phenyl]propanoate (ITE), a Newly Developed Anti-inflammatory Drug, on Type II Collagen-Induced Arthritis in Mice(Pharmacology)
- Efficacy and safety of rituximab in type II mixed delayed-type hypersensitivity reaction or serum sickness after rituximab treatment cryoglobulinemia
Related Links
- TRU Nursing Students explaining the pathophysiology of a type II Hypersensitivity reaction during an incompatible blood transfusion as their HLSC 3550 (advanced pathophysiology) project. Kayla, Amanda ...
- Information on the symptoms, treatment and diagnosis of hypersensitivity Type II by professional health specialists. ... What is Hypersensitivity reaction – Type II Statistics on Hypersensitivity reaction – Type II Risk Factors for ...
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