- 関
- Niemann-Pick disease type A
WordNet
- select carefully from a group; "She finally picked her successor"; "He picked his way carefully"
- remove in small bits; "pick meat from a bone"
- a heavy iron tool with a wooden handle and a curved head that is pointed on both ends; "they used picks and sledges to break the rocks" (同)pickax, pickaxe
- a small thin device (of metal or plastic or ivory) used to pluck a stringed instrument (同)plectrum, plectron
- a basketball maneuver; obstructing an opponent with ones body; "he was called for setting an illegal pick"
- a thin sharp implement used for removing unwanted material; "he used a pick to clean the dirt out of the cracks"
- attack with or as if with a pickaxe of ice or rocky ground, for example; "Pick open the ice" (同)break_up
- look for and gather; "pick mushrooms"; "pick flowers" (同)pluck, cull
- pilfer or rob; "pick pockets"
- provoke; "pick a fight or a quarrel"
- write by means of a keyboard with types; "type the acceptance letter, please" (同)typewrite
- a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper; "he dropped a case of type, so they made him pick them up"
- (biology) the taxonomic group whose characteristics are used to define the next higher taxon
- a subdivision of a particular kind of thing; "what type of sculpture do you prefer?"
- all of the tokens of the same symbol; "the word `element contains five different types of character"
- printed characters; "small type is hard to read"
- identify as belonging to a certain type; "Such people can practically be typed" (同)typecast
- an impairment of health or a condition of abnormal functioning
- the 1st letter of the Roman alphabet (同)a
- the blood group whose red cells carry the A antigen (同)type_A, group A
- caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological
PrepTutorEJDIC
- (入念に)…‘を'『選ぶ』,選び取る / 〈草花・果実など〉‘を'『摘む』,もぐ / 〈鳥など〉‘の'羽をむしる;(…から)…‘を'むしる《+『名』+『from』+『名』》 / (とがった物で)…‘を'つつく,つついて穴をあける《+『名』+『with』+『名』》 / 〈鳥などが〉〈えさ〉‘を'つつく,つついて食べる / 〈争いなど〉‘を'しかける;(人に)〈口論など〉‘を'ふっかける《+『名』+『with』+『名』〈人〉》 / (針金などで)〈錠〉‘を'こじあける / 〈ポケット・さいふなど〉‘の'中身をすり取る / 〈弦楽器・弦〉‘を'指で鳴らす,つまびく / 入念に選ぶ / 〈鳥が〉えさをつつく;(食浴がなくて)〈人が〉(…を)少しずつ食べる《+『at』+『名』》 / 〈U〉(…の)選択(choice),(…を)選ぶこと(権利)《+『of』+『名』》 / 〈C〉(…から)選択された人(物);《the~》(…から)選ばれた最上の人(物)《+『of』+『名』》
- 《複合語を作って》「ほじる(つつく)道具」の意を表す / 《話》=plectrum
- 〈C〉(…の)『型』,タイプ,類型,種類(kind)《+of+名》 / 〈C〉(その種類の特質を最もよく表している)『典型』,手本,模範《+of+名》 / 〈U〉《集合的に》活字;〈C〉(1個の)活字 / 〈U〉(印刷された)字体,活字 / 〈C〉(貨幣・メダルなどの)模様,図柄 / 〈C〉血液型(blood group) / …‘を'タイプに打つ / (…として)…‘を'分類する《+名+as+名(doing)》 / …‘の'型を決める / タイプライターを打つ
- (体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
- 女性の話術芸人 =diseur
- answer / ampere
- 病気にかかった / 病的な,不健全な(morbid)
UpToDate Contents
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- 1. ニーマン・ピック病の概要 overview of niemann pick disease
- 2. アシュケナージ系ユダヤ人集団における遺伝的疾患の出生前スクリーニング prenatal screening for genetic disease in the ashkenazi jewish population
English Journal
- Clathrin-mediated endocytosis is impaired in type A-B Niemann-Pick disease model cells and can be restored by ICAM-1-mediated enzyme replacement.
- Rappaport J1, Garnacho C, Muro S.
- Molecular pharmaceutics.Mol Pharm.2014 Aug 4;11(8):2887-95. doi: 10.1021/mp500241y. Epub 2014 Jun 26.
- Drugs often use endocytosis to achieve intracellular delivery, either by passive uptake from the extracellular fluid or by active targeting of cell surface features such as endocytic receptors. An example is enzyme replacement therapy, a clinically practiced treatment for several lysosomal storage d
- PMID 24949999
- Pharmacological reversion of sphingomyelin-induced dendritic spine anomalies in a Niemann Pick disease type A mouse model.
- Arroyo AI1, Camoletto PG, Morando L, Sassoe-Pognetto M, Giustetto M, Van Veldhoven PP, Schuchman EH, Ledesma MD.
- EMBO molecular medicine.EMBO Mol Med.2014 Mar;6(3):398-413. doi: 10.1002/emmm.201302649. Epub 2014 Jan 21.
- Understanding the role of lipids in synapses and the aberrant molecular mechanisms causing the cognitive deficits that characterize most lipidosis is necessary to develop therapies for these diseases. Here we describe sphingomyelin (SM) as a key modulator of the dendritic spine actin cytoskeleton. W
- PMID 24448491
- Sphingomyelin lipidosis (Niemann-Pick disease) in a juvenile raccoon (Procyon lotor).
- Vapniarsky N1, Wenger DA, Scheenstra D, Mete A.
- Journal of comparative pathology.J Comp Pathol.2013 Aug-Oct;149(2-3):385-9. doi: 10.1016/j.jcpa.2013.01.011. Epub 2013 Apr 10.
- A wild caught juvenile male raccoon with neurological disease was humanely destroyed due to poor prognosis. Necropsy examination revealed hepatomegaly, splenomegaly and multicentric lymphadenomegaly with diffuse hepatic pallor and pulmonary consolidation with pinpoint pale subpleural foci. Microscop
- PMID 23582974
Japanese Journal
- 細胞内分解性ポリロタキサンによるニーマンピック病C型治療 (特集 革新的創薬開発と実用化)
- 化學工業 66(12), 925-932, 2015-12
- NAID 40020659142
- Niemann-Pick disease type C2 protein induces autophagy and inhibits growth in FM3A breast cancer cells
- Drug Discoveries & Therapeutics 9(4), 282-288, 2015
- NAID 130005098741
- CCL2 induces neural stem cell proliferation and neuronal differentiation in Niemann-Pick type C mice
- Journal of Veterinary Medical Science 77(6), 693-699, 2015
- NAID 130005085854
Related Links
- Niemann-Pick disease is a condition that affects many body systems. It has a wide range of symptoms that vary in severity. Niemann-Pick disease is divided into four main types: type A, type B, type C1, and type C2.
- Type A Niemann-Pick is a severe disease. It usually leads to death by age 2 or 3. Those with type B may live into late childhood or adulthood. A child who shows signs of type C before age 1 may not live to school age.
Related Pictures
★リンクテーブル★
| リンク元 | 「A型ニーマン・ピック病」「A型Niemann-Pick病」 |
| 関連記事 | 「disease」「type」「A」「Pi」「typed」 |
「A型ニーマン・ピック病」
- 英
- type A Niemann-Pick disease
- 関
- A型Niemann-Pick病、Niemann-Pick病A型
「A型Niemann-Pick病」
「disease」
- n.
- 疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)
- 特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)
- something that is very wrong with people's attitudes, way of life or with society.
- 注意
「type」
- n.
- (windows)ファイル内容表示(linux -> cat])
- ex. type report_20111118.jp.htm | php a.php > report_20111118.jp.jp.jp.html
「A」
「Pi」
「typed」
- adj.
- 型の