two hit model

ツーヒットモデル

WordNet

1. pay unsolicited and usually unwanted sexual attention to; "He tries to hit on women in bars"
2. the act of contacting one thing with another; "repeated hitting raised a large bruise"; "after three misses she finally got a hit" (同)hitting, striking
3. a conspicuous success; "that song was his first hit and marked the beginning of his career"; "that new Broadway show is a real smasher"; "the party went with a bang" (同)smash, smasher, strike, bang
4. (baseball) a successful stroke in an athletic contest (especially in baseball); "he came all the way around on Williams hit"
5. a connection made via the internet to another website; "WordNet gets many hits from users worldwide"
6. a dose of a narcotic drug
7. a murder carried out by an underworld syndicate; "it has all the earmarks of a Mafia hit"
8. affect or afflict suddenly, usually adversely; "We were hit by really bad weather"; "He was stricken with cancer when he was still a teenager"; "The earthquake struck at midnight" (同)strike
9. drive something violently into a location; "he hit his fist on the table"; "she struck her head on the low ceiling" (同)strike
10. cause to experience suddenly; "Panic struck me"; "An interesting idea hit her"; "A thought came to me"; "The thought struck terror in our minds"; "They were struck with fear" (同)strike, come_to
11. hit against; come into sudden contact with; "The car hit a tree"; "He struck the table with his elbow" (同)strike, impinge on, run_into, collide with
12. cause to move by striking; "hit a ball"
13. consume to excess; "hit the bottle"
14. deal a blow to, either with the hand or with an instrument; "He hit her hard in the face"
15. hit the intended target or goal
16. display (clothes) as a mannequin; "model the latest fashion"
17. the act of representing something (usually on a smaller scale) (同)modelling, modeling
18. representation of something (sometimes on a smaller scale) (同)simulation
19. a representative form or pattern; "I profited from his example" (同)example
20. a person who poses for a photographer or painter or sculptor; "the president didnt have time to be a model so the artist worked from photos" (同)poser
21. someone worthy of imitation; "every child needs a role model" (同)role model
22. a hypothetical description of a complex entity or process; "the computer program was based on a model of the circulatory and respiratory systems" (同)theoretical account, framework
23. a type of product; "his car was an old model"
24. construct a model of; "model an airplane" (同)mock up
25. form in clay, wax, etc; "model a head with clay" (同)mold, mould
26. plan or create according to a model or models (同)pattern
27. assume a posture as for artistic purposes; "We dont know the woman who posed for Leonardo so often" (同)pose, sit, posture
28. create a representation or model of; "The pilots are trained in conditions simulating high-altitude flights" (同)simulate
29. a particular functioning condition or arrangement; "switched from keyboard to voice mode"
30. the most frequent value of a random variable (同)modal value
31. any of various fixed orders of the various diatonic notes within an octave (同)musical mode
32. being one more than one; "he received two messages" (同)2, ii
33. the cardinal number that is the sum of one and one or a numeral representing this number (同)2, II, deuce
34. relating to a recently developed fashion or style; "their offices are in a modern skyscraper"; "tables in modernistic designs"; (同)modern, modernistic
35. a British teenager or young adult in the 1960s; noted for their clothes consciousness and opposition to the rockers

PrepTutorEJDIC

1. 〈人・物〉‘を'『打つ』,なぐる / …‘に'『ぶつかる』,衝突する / (…に)〈自分の体〉‘を'『ぶつける』《+『名』+『against』(『on』,『upon』)』+『名』》 / 《話》…‘に'達する / …‘に'ひどい打撃(結果)を与える / 《米》〈事が〉〈人〉‘に'ふと思い浮かぶ;〈人が〉…‘を'ふと見つける / (野球で)〈安打〉‘を'打つ;(クリケットで)〈…点〉‘を'取る / (武器などで)(…を)『打つ』,攻撃する《+『at』+『名』》 / (…に)『ぶつかる』,衝突する《+『against(on, upon)』+『名』》 / 襲う,急に現れる / 『打撃』,命中 / ヒット,大当たり,大成功 / (野球で)ヒット,安打(base hit) / 風刺,当てこすり
2. (通名縮小した)(…の)『模型』,ひな型《+『of』+『名』》 / 《単数形で》(…の)『模範』,手本《+『of』+(『for』)+『名』》 / (美術家・作家などの)モデル,ファッションモデル / (自動車・服装などの)型,式《+『of』+『名』》 / 《英》《単数形で》(…と)そっくりな人(物),(…の)生き写し《+『of』+『名』》 / 『模型の』,見本の / 『日範的な』,申し分のない / (ある材料で)…‘の'模型を作る,‘を'型どる《+『名』+『in』+『名』〈材料〉》 / (手本・型に合わせて)…‘を'作る《+『名』+『after』(『on, upon』)+『名』(a person's do『ing』)》 / 〈洋装・髪型などの〉‘の'モデルをする / (…で)(原型)を作る《+『in』+『名』》 / (ファッションショーなどで)モデルをする
3. 〈C〉(…の)『方法』,やり方,流儀《+『of』+『名』(do『ing』)》 / 〈U〉〈C〉(服装などの)『流行』,モード / 〈C〉(動詞の)法,叙法(mood) / 音階(scale)
4. 〈C〉(数の)『2』,2の記号 / 〈U〉2時,2分;2歳 / 《複数扱い》二人;2個 / 〈C〉二つ(二人,2個)1組のもの / 〈C〉(カードゲーム)2の札,(さいころの)2の目 / 2の;二人の;二つの,2個の / 《補語にのみ用いて》2歳の(で)
5. モッズふうな(服装・音楽などについて伝統にとらわれない考え方の一つ)[modernの短縮形]

UpToDate Contents

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• 1. ヘパリン起因性血小板減少症の臨床症状および診断 clinical presentation and diagnosis of heparin induced thrombocytopenia
• 2. ヘパリン起因性血小板減少症のマネージメント management of heparin induced thrombocytopenia
• 3. Overview of the treatment, prognosis, and follow-up of acute pulmonary embolism in adults
• 4. 静脈血栓症の原因の概要 overview of the causes of venous thrombosis
• 5. 下肢深部静脈血栓症の治療の概要 overview of the treatment of lower extremity deep vein thrombosis dvt

English Journal

• Synthesis of azepino[4,5-b]indol-4-ones via MCR/free radical cyclization and in vitro-in silico studies as 5-Ht6R ligands.

• Rentería-Gómez A1, Islas-Jácome A1, Díaz-Cervantes E2, Villaseñor-Granados T2, Robles J3, Gámez-Montaño R4.
• Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2016 May 1;26(9):2333-8. doi: 10.1016/j.bmcl.2016.03.036. Epub 2016 Mar 11.
• A series of nine new 3-acetamide-azepino[4,5-b]indol-4-ones were synthesized in two steps: (i) multicomponent reaction (Ugi-4CR/SN2) and (ii) free radical-mediated cyclization. These compounds, along with their tetrazole-based analogs, were studied in vitro to assess their binding with the 5-hydroxy
• PMID 26996373

• Genetic polymorphisms to predict gains in maximal O2 uptake and knee peak torque after a high intensity training program in humans.

• Yoo J1, Kim BH2, Kim SH1, Kim Y1,3, Yim SV4.
• European journal of applied physiology.Eur J Appl Physiol.2016 May;116(5):947-57. doi: 10.1007/s00421-016-3353-7. Epub 2016 Mar 21.
• PURPOSE: The study aimed to identify single nucleotide polymorphisms (SNPs) that significantly influenced the level of improvement of two kinds of training responses, including maximal O2 uptake (V'O2max) and knee peak torque of healthy adults participating in the high intensity training (HIT) progr
• PMID 27001664

• Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging?

• Shalev I1, Belsky J2.
• Medical hypotheses.Med Hypotheses.2016 May;90:41-7. doi: 10.1016/j.mehy.2016.03.002. Epub 2016 Mar 11.
• Two seemingly independent bodies of research suggest a two-hit model of accelerated aging, one highlighting early-life stress and the other reproduction. The first, informed by developmental models of early-life stress, highlights reduced longevity effects of early adversity on telomere erosion, whe
• PMID 27063083

Japanese Journal

• ヒット現象の数理モデルから見た社会現象の盛り上がりに関する考察

• 石井 晃,小籔 拓馬,北尾 明子,鳥海 不二夫,榊 剛史
• 研究報告知能システム（ICS） 2015-ICS-178(10), 1-7, 2015-02-23
• … A mathematical theory for social events is presented based on a former mathematical model for the hit phenomenon in entertainment as a stochastic process of interactions of human dynamics. … The model uses only the time distribution of advertisement budget as an input, and word-of-mouth (WOM) represented by posts on social network systems is used as data to compare with the calculated results. …
• NAID 170000093088

• ヒット現象の数理モデルから見た社会現象の盛り上がりに関する考察

• 石井 晃,小籔 拓馬,北尾 明子,鳥海 不二夫,榊 剛史
• 情報処理学会研究報告. ICS, [知能と複雑系] 2015-ICS-178(10), 1-7, 2015-02-23
• … A mathematical theory for social events is presented based on a former mathematical model for the hit phenomenon in entertainment as a stochastic process of interactions of human dynamics. … The model uses only the time distribution of advertisement budget as an input, and word-of-mouth (WOM) represented by posts on social network systems is used as data to compare with the calculated results. …
• NAID 110009882535

• Biallelic Disruption of the PTCH1 Gene in Multiple Basal Cell Carcinomas in Japanese Patients with Nevoid Basal Cell Carcinoma Syndrome

• Tate Genshu,Kishimoto Koji,Mitsuya Toshiyuki
• Acta Medica Okayama 68(3), 163-170, 2014-06
• … These results indicate that the germline single base deletion of PTCH1 (c.2613 delC) is a first hit and the LOH of the wild-type allele is a second hit, implying that all 16 BCCs detected in these NBCCS sisters fit the standard two-hit model. …
• NAID 120005447129

Related Links

• Knudson hypothesis - Wikipedia, the free encyclopedia

In non-inherited retinoblastoma, two "hits" had to take place before a tumor could develop, explaining the age ... Under this model, cancer arises as the result of a single, isolated event, rather than the slow accumulation of multiple mutations.

• two-hit model: Definition from Answers.com

two-hit model ( t hit ¦mdl ) ( genetics ) The hypothesis that a cancer arises in an individual heterozygous for a.

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★リンクテーブル★

リンク元	「ツーヒットモデル」
関連記事	「mode」「hit」「model」「HIT」

「ツーヒットモデル」

　　[★]

英

two-hit model, two hit model

関

ツーヒット説

「mode」

　　[★]

• n.

• モード、型、機序、方法

関

fashion、form、manner、means、mechanism、method、pattern、procedure、process、type、typed、way

　 　 　 　

「hit」

　　[★]

• n.

• ヒット、(スクリーニング等での)的中

• v.

• 打つ

関

beat、strike

　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　

「model」

　　[★]

• n.

• モデル、模型

　 　 　 　 　 　 　 　 　 　 　 　 　 　

「HIT」

　　[★] ヘパリン起因性血小板減少症 heparin-induced thrombocytopenia