two-pore domain channels

出典: meddic


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英文文献

  • The two-pore domain K2 P channel TASK2 drives human NK-cell proliferation and cytolytic function.
  • Schulte-Mecklenbeck A1, Bittner S1,2, Ehling P1, Döring F3, Wischmeyer E3, Breuer J1, Herrmann AM1, Wiendl H1, Meuth SG1, Gross CC1.
  • European journal of immunology.Eur J Immunol.2015 Sep;45(9):2602-14. doi: 10.1002/eji.201445208.
  • Natural killer (NK) cells are a subset of cytotoxic lymphocytes that recognize and kill tumor- and virus-infected cells without prior stimulation. Killing of target cells is a multistep process including adhesion to target cells, formation of an immunological synapse, and polarization and release of
  • PMID 26140335
  • How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.
  • Brohawn SG1.
  • Annals of the New York Academy of Sciences.Ann N Y Acad Sci.2015 Aug 31. doi: 10.1111/nyas.12874. [Epub ahead of print]
  • The ability to sense and respond to mechanical forces is essential for life and cells have evolved a variety of systems to convert physical forces into cellular signals. Within this repertoire are the mechanosensitive ion channels, proteins that play critical roles in mechanosensation by transducing
  • PMID 26332952
  • Role of leak potassium channels in pain signaling.
  • Li XY1, Toyoda H2.
  • Brain research bulletin.Brain Res Bull.2015 Aug 28. pii: S0361-9230(15)30025-3. doi: 10.1016/j.brainresbull.2015.08.007. [Epub ahead of print]
  • Potassium (K+) channels are membrane proteins that allow rapid and selective flow of K+ ions across the cell membrane, generating electrical signals in neurons. Thus, K+ channels play a critical role in determining the neuronal excitability. Two-pore domain (K2P) "leak" K+ channels give rise to leak
  • PMID 26321392

和文文献

  • 1P222 哺乳類two-pore型カリウムチャネルTWIK-1の全反射赤外分光解析(13C. 生体膜・人工膜:興奮・チャンネル,ポスター,日本生物物理学会年会第51回(2013年度))
  • Tsukamoto Hisao,Nakajo Koichi,Kubo Yoshihiro,Furutani Yuji
  • 生物物理 53(SUPPLEMENT_1-2), S142, 2013-09-13
  • NAID 110009819394
  • Rank-ordered Recruitment of Masseter Motoneurons during Slow Closing Phase of Mastication Cycle Presumably by the Activity of Mesencephalic Trigeminal Neurons
  • Kang Youngnam,Saito Mitsuru,Toyoda Hiroki,Sato Hajime
  • Journal of Oral Biosciences 52(4), 330-335, 2010
  • Two-pore-domain acid-sensitive K+ (TASK1/3) channels were recently found to be the molecular correlates of input resistance, and were also found to be expressed in the masseter motoneurons. … Here, we discuss the possibility that spindle Ia inputs can induce the orderly recruitment of masseter motoneurons, and the possible involvements of TASK channels in the orderly recruitment. …
  • NAID 130004475716

関連リンク

Following refinement of experimental strategies to allow investigators to explore the biophysical and functional properties K2P channels with more confidence, structural analysis became an obvious priority. Toward this end, two ...
The two-pore-domain K+ channels, or K2P channels, constitute a novel class of K+channel subunits. They have four transmembrane segments and are active as dimers. The tissue distribution of these channels is widespread, and ...

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★リンクテーブル★
関連記事channel」「domain」「two」「pore」「channels

channel」

  [★]

  • n.
  • 川床、川底。水路、河道
  • 海峡
  • 水管、導管
  • 経路、ルート。道筋、方向
ion channelionic channel

WordNet   license wordnet

「direct the flow of; "channel information towards a broad audience"」
canalize, canalise

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「a television station and its programs; "a satellite TV channel"; "surfing through the channels"; "they offer more than one hundred channels"」
television channel, TV channel

WordNet   license wordnet

「a passage for water (or other fluids) to flow through; "the fields were crossed with irrigation channels"; "gutters carried off the rainwater into a series of channels under the street"」

WordNet   license wordnet

「(often plural) a means of communication or access; "it must go through official channels"; "lines of communication were set up between the two firms"」
communication channel, line

WordNet   license wordnet

「a path over which electrical signals can pass; "a channel is typically what you rent from a telephone company"」
transmission channel

WordNet   license wordnet

「a deep and relatively narrow body of water (as in a river or a harbor or a strait linking two larger bodies) that allows the best passage for vessels; "the ship went aground in the channel"」

PrepTutorEJDIC   license prepejdic

「〈C〉『水路』(川・湾・運河の船の通行ができる深い部分) / 〈U〉河床・川底 / 〈C〉『海峡』 / 〈C〉みぞ(groove),(道路の)水渠(すいきょ) / 《複数形で》(運搬・伝達の)正式の経路(手続き);(一般に)経路 / 〈C〉(テレビ・ラジオの)チャンネル / …‘に'水路を開く / …‘に'みぞを堀る / …'を'伝える,流す」


domain」

  [★]

  • n.
arearealmregionregionalsegregationterritoryuniverse

WordNet   license wordnet

「territory over which rule or control is exercised; "his domain extended into Europe"; "he made it the law of the land"」
demesne, land

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「(mathematics) the set of values of the independent variable for which a function is defined」
domain of a function

PrepTutorEJDIC   license prepejdic

「(国の)領地,領土;(個人の)所有地 / (関心・活動などの)範囲,分野 / (個人・一族の)所有地 / (数学で)変域(関数の独立変数がとる値の集合)」


two」

  [★]

WordNet   license wordnet

「being one more than one; "he received two messages"」
2, ii

WordNet   license wordnet

「the cardinal number that is the sum of one and one or a numeral representing this number」
2, II, deuce

PrepTutorEJDIC   license prepejdic

「〈C〉(数の)『2』,2の記号 / 〈U〉2時,2分;2歳 / 《複数扱い》二人;2個 / 〈C〉二つ(二人,2個)1組のもの / 〈C〉(カードゲーム)2の札,(さいころの)2の目 / 2の;二人の;二つの,2個の / 《補語にのみ用いて》2歳の(で)」


pore」

  [★] 細孔

WordNet   license wordnet

「any tiny hole admitting passage of a liquid (fluid or gas)」

WordNet   license wordnet

「any small opening in the skin or outer surface of an animal」

PrepTutorEJDIC   license prepejdic

「《pore over+名》(…を)熟読する,注意深く考える・没頭する, 熟考[熟視,熟読]する」

PrepTutorEJDIC   license prepejdic

「気孔,毛穴」


channels」

  [★] チャネル

WordNet   license wordnet

「official routes of communication; "you have to go through channels"」




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