WordNet
- indicate the dimensions on; "These techniques permit us to dimension the human heart"
- shape or form to required dimensions
- the magnitude of something in a particular direction (especially length or width or height)
- one of three Cartesian coordinates that determine a position in space
- being one more than one; "he received two messages" (同)2, ii
- the cardinal number that is the sum of one and one or a numeral representing this number (同)2, II, deuce
- of or relating to dimensions
- having dimension--the quality or character or stature proper to a person; "never matures as a dimensional character; he is pasty, bland, faceless"- Norman Cousins
- the motion of charged particles in a colloid under the influence of an electric field; particles with a positive charge go to the cathode and negative to the anode (同)cataphoresis, dielectrolysis, ionophoresis
PrepTutorEJDIC
- 〈C〉(長さ・幅・厚さなどの)『寸法』 / 《通例複数形で》大きさ,範囲,規模 / 〈C〉広がり,展望(scope) / 〈C〉(数学で)次元
- 〈C〉(数の)『2』,2の記号 / 〈U〉2時,2分;2歳 / 《複数扱い》二人;2個 / 〈C〉二つ(二人,2個)1組のもの / 〈C〉(カードゲーム)2の札,(さいころの)2の目 / 2の;二人の;二つの,2個の / 《補語にのみ用いて》2歳の(で)
- (長さ・幅・厚さなどの)寸法の / (数学で)…次元の
UpToDate Contents
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- 1. 臨床腫瘍学における遺伝子発現プロファイリング、プロテオミクス、およびマイクロRNAプロファイリングの概要 overview of gene expression profiling proteomics and microrna profiling in clinical oncology
- 2. 肝線維症の非侵襲的評価：超音波エラストグラフィ noninvasive assessment of hepatic fibrosis ultrasound based elastography
- 3. 三次元心エコー検査 three dimensional echocardiography
- 4. 異常ヘモグロビン症の検査室診断 laboratory diagnosis of the hemoglobinopathies
- 5. モノクローナル蛋白の認識 recognition of monoclonal proteins
English Journal
- Gold-nanobeacons for gene therapy: evaluation of genotoxicity, cell toxicity and proteome profiling analysis.
- Conde J, Larguinho M, Cordeiro A, Raposo LR, Costa PM, Santos S, Diniz MS, Fernandes AR, Baptista PV.Author information CIGMH, DCV, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa , Caparica , Portugal.AbstractAntisense therapy is a powerful tool for post-transcriptional gene silencing suitable for down-regulating target genes associated to disease. Gold nanoparticles have been described as effective intracellular delivery vehicles for antisense oligonucleotides providing increased protection against nucleases and targeting capability via simple surface modification. We constructed an antisense gold-nanobeacon consisting of a stem-looped oligonucleotide double-labelled with 3'-Cy3 and 5'-Thiol-C6 and tested for the effective blocking of gene expression in colorectal cancer cells. Due to the beacon conformation, gene silencing was directly detected as fluorescence increases with hybridisation to target, which can be used to assess the level of silencing. Moreover, this system was extensively evaluated for the genotoxic, cytotoxic and proteomic effects of gold-nanobeacon exposure to cancer cells. The exposure was evaluated by two-dimensional protein electrophoresis followed by mass spectrometry to perform a proteomic profile and 3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay, glutathione-S-transferase assay, micronucleus test and comet assay to assess the genotoxicity. This integrated toxicology evaluation showed that the proposed nanotheranostics strategy does not exhibit significant toxicity, which is extremely relevant when translating into in vivo systems.
- Nanotoxicology.Nanotoxicology.2014 Aug;8(5):521-32. doi: 10.3109/17435390.2013.802821. Epub 2013 May 28.
- Antisense therapy is a powerful tool for post-transcriptional gene silencing suitable for down-regulating target genes associated to disease. Gold nanoparticles have been described as effective intracellular delivery vehicles for antisense oligonucleotides providing increased protection against nucl
- PMID 23642008
- Comparative proteomic analysis of green malts between barley (Hordeum vulgare) cultivars.
- Jin Z1, Cai GL1, Li XM1, Gao F1, Yang JJ1, Lu J2, Dong JJ3.Author information 1The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China.2The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China; Industrial Technology Research Institute of Jiangnan University in Suqian, 888 Renmin Road, Suqian 223800, China. Electronic address: jlu@jiangnan.edu.cn.3State Key Laboratory of Biological Fermentation Engineering of Beer, Technical Center of Tsingtao Brewery Co. Ltd., Qingdao 266061, China.AbstractThe variety of metabolic proteins theoretically reaches a peak at the end of germination in large-scale malting. In the present study, comparative proteomics based on two-dimensional fluorescent difference gel electrophoresis (2D-DIGE) was employed to quantitatively analyse the low-salt soluble proteins in green malts from cultivars of Dan'er and Metcalfe. Fifty-nine metabolic proteins with significant differences between cultivars were successfully identified using MALDI-TOF/TOF. The roles of differential proteins in malt quality discrimination were elucidated according to their functions. Among them, 18 proteins exhibited differences in the green malts but not in the malts between the two cultivars. They could be considered as supplementary contributors to the quality defects of Dan'er malt, and new markers for malt quality improvement.
- Food chemistry.Food Chem.2014 May 15;151:266-70. doi: 10.1016/j.foodchem.2013.11.065. Epub 2013 Nov 21.
- The variety of metabolic proteins theoretically reaches a peak at the end of germination in large-scale malting. In the present study, comparative proteomics based on two-dimensional fluorescent difference gel electrophoresis (2D-DIGE) was employed to quantitatively analyse the low-salt soluble prot
- PMID 24423531
- Serpin B5 is a CEA-interacting biomarker for colorectal cancer.
- Baek JY, Yeo HY, Chang HJ, Kim KH, Kim SY, Park JW, Park SC, Choi HS, Kim DY, Oh JH.Author information Center for Colorectal Cancer, National Cancer Center, Goyang, Republic of Korea.AbstractSerpin B5 is a candidate tumour suppressor, but its oncogenic activity has also been reported. Its function may be affected by protein interactions. The aim of this study was to assess the relationship between serpin B5 and carcinoembryonic antigen (CEA) expression in colorectal cancer (CRC). We also analysed the clinicopathological significance of serpin B5 expression in patients with CRC. Downregulation of serpin B5 was identified in a CEA-suppressed LoVo cell line using two-dimensional gel electrophoresis (2-DE) and matrix-associated laser desorption ionisation-mass spectrometry (MALDI-MS). The specific interaction and co-localisation of serpin B5 with CEA were confirmed by co-immunoprecipitation and confocal microscopy. Western blot analysis and ELISAs revealed significant positive correlations between levels of serpin B5 and CEA in human colon cancer cell lines and in the blood of patients with CRC. Tissue expression of serpin B5 in 377 patients with CRC was significantly associated with serum CEA, histological grade, stage, lymph node metastasis, lymphatic and perineural invasion, and infiltrative border. Strong expression of serpin B5 was also associated with a reduced DFS (p = 0.001) and OS (p = 0.017). Together, these findings describe a relationship between serpin B5 and CEA expression in CRC. Strong expression of serpin B5 was associated with a worse prognosis in patients with CRC and its expression may correlate with CEA levels in CRC.
- International journal of cancer. Journal international du cancer.Int J Cancer.2014 Apr 1;134(7):1595-604. doi: 10.1002/ijc.28494. Epub 2013 Oct 11.
- Serpin B5 is a candidate tumour suppressor, but its oncogenic activity has also been reported. Its function may be affected by protein interactions. The aim of this study was to assess the relationship between serpin B5 and carcinoembryonic antigen (CEA) expression in colorectal cancer (CRC). We als
- PMID 24114705
Japanese Journal
- In-gel phosphatase assay using non-denaturing two-dimensional electrophoresis
- Baba Hiromi,Masuda Yukihiro,Sueyoshi Noriyuki
- The journal of biochemistry 152(6), 557-563, 2012-12
- NAID 40019523908
- Comparative analysis of cells and proteins of pumpkin plants for the control of fruit size(PLANT BIOTECHNOLOGY)
- Nakata Yumiko,Taniguchi Go,Takazaki Shinya,Oda-Ueda Naoko,Miyahara Kohji,Ohshima Yasumi
- Journal of bioscience and bioengineering 114(3), 334-341, 2012-09
- … We also compared protein patterns in the leaves, stems, ripe and young fruits by two-dimensional (2D) gel electrophoresis, and identified those differentially expressed between them with mass spectroscopy. …
- NAID 110009517387
- 卵製品の品質・機能向上を目的とした鶏卵のプロテオーム解析
- 石川 伸一
- 日本食品科学工学会誌 : Nippon shokuhin kagaku kogaku kaishi = Journal of the Japanese Society for Food Science and Technology 59(5), 231-235, 2012-05-15
- … Molecular changes in egg white proteins during storage have been investigated using two-dimensional electrophoresis coupled with mass spectrometry. …
- NAID 10030655480
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★リンクテーブル★
| リンク元 | 「two-dimensional gel electrophoresis」「二次元電気泳動」「二次元電気泳動法」 |
| 関連記事 | 「electrophoresis」「dimension」「dimensional」 |
「two-dimensional gel electrophoresis」
「二次元電気泳動」
- 英
- two-dimensional electrophoresis、two-dimensional gel electrophoresis
- 関
- 二次元ゲル電気泳動法、二次元ゲル電気泳動、二次元電気泳動法
「二次元電気泳動法」
「electrophoresis」
「dimension」
「dimensional」
- 次元の