WordNet
- mark with lines; "sorrow had lined his face"
- a length (straight or curved) without breadth or thickness; the trace of a moving point
- a single frequency (or very narrow band) of radiation in a spectrum
- reinforce with fabric; "lined books are more enduring"
- a particular kind of product or merchandise; "a nice line of shoes" (同)product line, line of products, line of merchandise, business line, line of business
- the road consisting of railroad track and roadbed (同)railway line, rail line
- a commercial organization serving as a common carrier
- acting in conformity; "in line with"; "he got out of line"; "toe the line"
- something (as a cord or rope) that is long and thin and flexible; "a washing line"
- a conceptual separation or distinction; "there is a narrow line between sanity and insanity" (同)dividing_line, demarcation, contrast
- a formation of people or things one behind another; "the line stretched clear around the corner"; "you must wait in a long line at the checkout counter"
- a formation of people or things one beside another; "the line of soldiers advanced with their bayonets fixed"; "they were arrayed in line of battle"; "the cast stood in line for the curtain call"
- a fortified position (especially one marking the most forward position of troops); "they attacked the enemys line"
- a mark that is long relative to its width; "He drew a line on the chart"
- a spatial location defined by a real or imaginary unidimensional extent
- in games or sports; a mark indicating positions or bounds of the playing area
- persuasive but insincere talk that is usually intended to deceive or impress; "`let me show you my etchings is a rather worn line"; "he has a smooth line but I didnt fall for it"; "that salesman must have practiced his fast line of talk"
- text consisting of a row of words written across a page or computer screen; "the letter consisted of three short lines"; "there are six lines in every stanza"
- be in line with; form a line along; "trees line the riverbank" (同)run along
- cover the interior of; "line the gloves"; "line a chimney"
- fill plentifully; "line ones pockets"
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- providing something with a surface of a different material (同)facing
- a protective covering that protects an inside surface (同)liner
- the act of attaching an inside lining (to a garment or curtain etc.)
- having a lining or a liner; often used in combination; "a lined skirt"; "a silk-lined jacket"
- (used especially of skin) marked by lines or seams; "their lined faces were immeasurably sad"; "a seamed face" (同)seamed
- bordered by a line of things; "tree lined streets"
PrepTutorEJDIC
- 『線』,筋,けい / (色・縫い目などの)『線』,しま;(顔・手などの)しわ(wrinkle) / (物・人の)『列』,行列(row) / 『綱』,糸,針金 / 電線,電話線,電信線 / (文章の)『行』;(詩の)『行』 / 《しばしばa~》《話》『短い手紙』(note) / 《複数形で》輪郭,外形(outline) / 境界線(boundary);限界,限度(limit) / (鉄道・バスなどの)路線;航路,空路 / 《複数形で》せりふ / 進路,道順(course);(考えなどの)筋道,方針 / 《しばしばone's~》(活動の)分野,方面;特意 / 家系,血統,血筋 / 在庫商品,仕入れ品 / 導管,パイプライン / 《しばしば複数形で》戦線,防御線 / …‘に'『線を引く』,筋(しま,しわ)をつける / …‘に'『沿って並ぶ;』(…を)…‘に'沿って並べる《+『名』+『with』+『名』》
- (材料で)〈着物など〉‘に'裏を付ける《+『名』『with』+『名』》 / (…で)…‘を'満たす,(…を)…‘に'詰め込む《+『名』+『with』+『名』》
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
- 〈U〉(服などの)裏張り,裏塗り / 〈U〉裏地,裏材
UpToDate Contents
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- 1. 縦隔および後腹膜を含む性腺外胚細胞腫瘍 extragonadal germ cell tumors involving the mediastinum and retroperitoneum
- 2. 進展型小細胞肺癌患者に対するファーストライン化学療法 first line chemotherapy for patients with extensive stage small cell lung cancer
- 3. 再発性の難治性精巣胚細胞腫瘍の治療 treatment of relapsed and refractory testicular germ cell tumors
- 4. 進行腎細胞癌または転移性腎細胞癌に対する抗血管新生療法および分子標的療法 anti angiogenic and molecularly targeted therapy for advanced or metastatic renal cell carcinoma
- 5. 頭頸部の扁平上皮癌化：分子学的および遺伝学的変化 head and neck squamous cell carcinogenesis molecular and genetic alterations
English Journal
- Design, characterization and in vitro evaluation of SMEDDS containing an anticancer peptide, linear LyP-1.
- Gürsoy RN, Çevik Ö.Author information Pharmaceutical Technology Department, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.AbstractLyP-1 (CGNKRTRGC) is a nine amino acid peptide that shows high specificity for tumor lymphatics. The aim of this study was to develop lipid-based formulations containing the linear form of LyP-1 for lymphatic targeting. Self-microemulsifying drug delivery systems (SMEDDS) were designed for the delivery of linear LyP-1 by itself and as a solid dispersion (SD). Formulations were characterized in terms of physical stability, pH, morphological properties, droplet size distribution and zeta potential. Thermodynamically stable microemulsions were obtained with an average droplet size around 20 nm and zeta potential near neutrality. Cytotoxicity studies of blank and peptide-containing SMEDDS were carried out on Caco-2 cell line. Bioactivity studies of peptide-containing formulations were carried out on MDA-MB-231 breast cancer cell line. It was shown that blank and peptide-containing SMEDDS formulations were not cytotoxic to Caco-2 cell line. However, formulations containing the peptide and peptide SD led to a significant decrease in cell viability on breast cancer cells. It could be concluded that the SMEDDS formulations containing the linear LyP-1 were successfully developed for the lymphatic targeting of solid tumors in vitro.
- Pharmaceutical development and technology.Pharm Dev Technol.2014 Jun;19(4):486-90. doi: 10.3109/10837450.2013.795170. Epub 2013 May 16.
- LyP-1 (CGNKRTRGC) is a nine amino acid peptide that shows high specificity for tumor lymphatics. The aim of this study was to develop lipid-based formulations containing the linear form of LyP-1 for lymphatic targeting. Self-microemulsifying drug delivery systems (SMEDDS) were designed for the deliv
- PMID 23678858
- Impact of S100A8/A9 Expression on Prostate Cancer Progression In Vitro and In Vivo.
- Grebhardt S, Müller-Decker K, Bestvater F, Hershfinkel M, Mayer D.Author information Hormones and Signal Transduction Group, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany.AbstractThe proinflammatory S100A8/A9 proteins, which are expressed in myeloid cells under physiological conditions, are strongly expressed in human prostate cancer epithelial cells. Their role in the tumor cells and in tumor progression is largely unclear. We established a prostate cancer epithelial cell line (PC-3 TO-A8/A9) expressing S100A8 and S100A9 simultaneously under doxycycline control, to study the role of S100A8/A9 on tumor growth and infiltration of immune cells in subcutaneous xenografts in male NMRI nu/nu mice. Colonization of distant organs was studied after intracardial injection of the tumor cells in male NOD/SCID mice. PC-3 TO-A8/A9 cells grown in vitro and subcutaneous xenografts in mice not treated with doxycycline expressed high levels of S100A8/A9 mRNA and protein, whereas doxycycline treatment suppressed S100A8/A9 expression. S100A8/A9 expression did not significantly alter growth rate and invasion of the subcutaneous tumors into surrounding tissues. However, S100A8/A9 expression caused increased infiltration of immune cells, especially neutrophils. In intracardially injected mice sporadic tumor settlement was observed in muscle and lymph nodes. Colonies of tumor cells and micro-metastases were observed in the lung of 64.3% (9 out of 14) of mice not treated with doxycycline and in 33.3% (5 out of 15) of mice treated with doxycycline. Our data demonstrate for the first time that S100A8/A9 expression in epithelial cancer cells causes enhanced infiltration of immune cells, especially neutrophils, and stimulates settlement of the cancer cells in the lung. J. Cell. Physiol. 229: 661-671, 2014. © 2013 Wiley Periodicals, Inc.
- Journal of cellular physiology.J Cell Physiol.2014 May;229(5):661-71. doi: 10.1002/jcp.24489.
- The proinflammatory S100A8/A9 proteins, which are expressed in myeloid cells under physiological conditions, are strongly expressed in human prostate cancer epithelial cells. Their role in the tumor cells and in tumor progression is largely unclear. We established a prostate cancer epithelial cell l
- PMID 24122301
- Effect of ultrasound irradiation on bacterial internalization and bacteria-mediated gene transfer to cancer cells.
- Ninomiya K1, Yamada R2, Meisaku H2, Shimizu N3.Author information 1Institute of Nature and Environmental Technology, Kanazawa University, Kanazawa 920-1192, Japan.2Division of Natural System, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan.3Institute of Nature and Environmental Technology, Kanazawa University, Kanazawa 920-1192, Japan. Electronic address: nshimizu@t.kanazawa-u.ac.jp.AbstractThe present study demonstrates that ultrasound irradiation can facilitate bacteria-mediated gene delivery (bactofection). Escherichia coli modified with avidin were employed as a vehicle for delivery of the green fluorescent protein (GFP) gene, a model heterologous gene, into the breast cancer cell line MCF-7. Avidin-mediated binding of E. coli to MCF-7 cells enhanced the internalization of E. coli by approximately 17%, irrespective of the use of ultrasound irradiation. Furthermore, the use of ultrasound irradiation increased the internalization by approximately 5%, irrespective of the presence of avidin on the E. coli cell surface. The percentages of GFP-expressing MCF-7 cells at 24h after bactofection were below 0.5% and 2% for the case with only avidin-modification of E. coli cell surface and only ultrasound irradiation, respectively. However, combining avidin modification with the ultrasound treatment increased this value to 8%. Thus, the use of avidin-modified bacteria in conjunction with ultrasound irradiation has potential as an effective strategy for tumor-targeted bactofection.
- Ultrasonics sonochemistry.Ultrason Sonochem.2014 May;21(3):1187-93. doi: 10.1016/j.ultsonch.2013.12.005. Epub 2013 Dec 15.
- The present study demonstrates that ultrasound irradiation can facilitate bacteria-mediated gene delivery (bactofection). Escherichia coli modified with avidin were employed as a vehicle for delivery of the green fluorescent protein (GFP) gene, a model heterologous gene, into the breast cancer cell
- PMID 24373691
Japanese Journal
- Inhibitory effect of sulphated polysaccharide porphyran on nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophages
- Jiang Zedong,Hama Yoichiro,Yamaguchi Kenichi [他]
- Journal of Biochemistry 151(1), 65-74, 2012-01
- … Porphyran, extracted from an edible red alga (Porphyra yezoensis), is a sulphated polysaccharide with a wide variety of biological activities including anti-tumour, antioxidant and immuno-modulating activities. … In this study, we examined the effect of porphyran on nitric oxide (NO) production in mouse macrophage cell line RAW264.7 cells. …
- NAID 40019452577
- Vitamin K2-derived Compounds Induce Growth Inhibition in Radioresistant Cancer Cells
- AMALIA HELFI,SASAKI RYOHEI,SUZUKI YOKO,DEMIZU YUSUKE,BITO TOSHINORI,NISHIMURA HIDEKI,OKAMOTO YOSHIAKI,YOSHIDA KENJI,MIYAWAKI DAISUKE,KAWABE TETSUYA,MIZUSHINA YOSHIYUKI,SUGIMURA KAZURO
- The Kobe journal of the medical sciences 56(2), 38-49, 2010
- … Radioresistant tumour models were originally established from human colon cancer cells, and we evaluated their molecular basis. … Human colon, lung, and breast cancer cell lines were used for testing the growth inhibitory activities of several chemical compounds. … Radioresistant tumour models were established by fractionated radiation exposure. …
- NAID 110007670720
- Effectiveness of Monoenergetic and Spread-Out Bragg Peak Carbon-Ions for Inactivation of Various Normal and Tumour Human Cell Lines
- BELLI Mauro,BETTEGA Daniela,CALZOLARI Paola,CHERUBINI Roberto,CUTTONE Giacomo,DURANTE Marco,ESPOSITO Giuseppe,FURUSAWA Yoshiya,GERARDI Silvia,GIALANELLA Giancarlo,GROSSI Gianfranco,MANTI Lorenzo,MARCHESINI Renato,PUGLIESE Mariagabriella,SCAMPOLI Paola,SIMONE Giustina,SORRENTINO Eugenio,TABOCCHINI Maria Antonella,TALLONE Lucia
- Journal of radiation research 49(6), 597-607, 2008-11-16
- … This work aimed at measuring cell-killing effectiveness of monoenergetic and Spread-Out Bragg Peak (SOBP) carbon-ion beams in normal and tumour cells with different radiation sensitivity. …
- NAID 110006985819
Related Links
- Ma-Mel 1, 2, 3....48, Human, A range of melanoma cell lines. MC-38, Mouse, Adenocarcinoma. MCF-7, Michigan Cancer Foundation-7, Human, Mammary gland, Invasive breast ductal carcinoma, ER+, PR+ ...
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★リンクテーブル★
| リンク元 | 「腫瘍細胞株」 |
| 関連記事 | 「LINE」「line」「tumour」「cell line」「lining」 |
「腫瘍細胞株」
- 英
- tumour cell line
- ((英))tumour cell line
「LINE」
- 日
- 長い散在反復配列、長散在型反復配列、長い散在性反復配列、ライン、広範囲散在反復配列
- 英
- long interspersed nuclear element, long interspersed nucleotide element, long interspersed element, long interspersed repetitive elements, LINEs, long interspersed repeat sequences
- 関
- レトロトランスポゾン
- Long interspersed nuclear elements[8] are a group of genetic elements that are found in large numbers in eukaryotic genomes. They are transcribed (or are the evolutionary remains of what was once transcribed) to an RNA using an RNA polymerase II promoter that resides inside the LINE. LINEs code for the enzyme reverse transcriptase, and many LINEs also code for an endonuclease (e.g. RNase H). The reverse transcriptase has a higher specificity for the LINE RNA than other RNA, and makes a DNA copy of the RNA that can be integrated into the genome at a new site.
- The 5' UTR contains the promoter sequence, while the 3' UTR contains a polyadenylation signal (AATAAA) and a poly-A tail.[10] Because LINEs move by copying themselves (instead of moving, like transposons do), they enlarge the genome. The human genome, for example, contains about 20,000-40,000 LINEs, which is roughly 21% of the genome.
「line」
- n.
- v.
- 裏打ちする
「tumour」
- n.
「cell line」
「lining」
- n.