WordNet

to put down by force or authority; "suppress a nascent uprising"; "stamp down on littering"; "conquer ones desires" (同)stamp down, inhibit, subdue, conquer, curb
reduce the incidence or severity of or stop; "suppress a yawn"; "this drug can suppress the hemorrhage"
put out of ones consciousness (同)repress
an electrical device for suppressing unwanted currents (同)suppresser
someone who suppresses; "dictators are suppressors of free speech" (同)suppresser
a gene that suppresses the phenotypic expression of another gene (especially of a mutant gene) (同)suppresser, suppressor_gene, suppresser gene
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
an abnormal new mass of tissue that serves no purpose (同)tumour, neoplasm

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1. 前立腺癌の分子生物学 molecular biology of prostate cancer
2. 慢性骨髄性白血病の細胞生物学および分子生物学 cellular and molecular biology of chronic myeloid leukemia
3. 頭頸部の扁平上皮癌化：分子学的および遺伝学的変化 head and neck squamous cell carcinogenesis molecular and genetic alterations
4. 大腸癌の分子遺伝学 molecular genetics of colorectal cancer
5. 甲状腺結節および非髄様甲状腺癌におけるオンコジーンおよび腫瘍抑制遺伝子 oncogenes and tumor suppressor genes in thyroid nodules and nonmedullary thyroid cancer

Somatotropinomas, but not nonfunctioning pituitary adenomas, maintain a functional apoptotic RET/Pit1/ARF/p53 pathway that is blocked by excess GDNF.

Diaz-Rodriguez E1, Garcia-Rendueles AR, Ibáñez-Costa A, Gutierrez-Pascual E, Garcia-Lavandeira M, Leal A, Japon MA, Soto A, Venegas E, Tinahones FJ, Garcia-Arnes JA, Benito P, Angeles Galvez M, Jimenez-Reina L, Bernabeu I, Dieguez C, Luque RM, Castaño JP, Alvarez CV.
Endocrinology.Endocrinology.2014 Nov;155(11):4329-40. doi: 10.1210/en.2014-1034. Epub 2014 Aug 19.
Acromegaly is caused by somatotroph cell adenomas (somatotropinomas [ACROs]), which secrete GH. Human and rodent somatotroph cells express the RET receptor. In rodents, when normal somatotrophs are deprived of the RET ligand, GDNF (Glial Cell Derived Neurotrophic Factor), RET is processed intracellu
PMID 25137025

[p14ARF enhances chemosensitivity to cisplatin in human osteosarcoma U2OS cells through p53 apoptotic pathway].

Yuan X1, Huang X, Chen Z, Liang S, Liao W.
Zhonghua yi xue za zhi.Zhonghua Yi Xue Za Zhi.2014 Nov;94(43):3443-6.
OBJECTIVE: To explore the effects of tumor suppressor p14ARF on chemosensitivity of human osteosarcoma U2OS cells to cisplatin and elucidate its molecular mechanism.METHODS: U2OS cells expressing no p14ARF and U2OS-ARF cells expressing p14ARF stably through stable transfection were treated with cisp
PMID 25622680

Cancer cell specific cytotoxic gene expression mediated by ARF tumor suppressor promoter constructs.

Kurayoshi K1, Ozono E2, Iwanaga R3, Bradford AP3, Komori H4, Ohtani K5.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2014 Jul 18;450(1):240-6. doi: 10.1016/j.bbrc.2014.05.102. Epub 2014 Jun 2.
In current cancer treatment protocols, such as radiation and chemotherapy, side effects on normal cells are major obstacles to radical therapy. To avoid these side effects, a cancer cell-specific approach is needed. One way to specifically target cancer cells is to utilize a cancer specific promoter
PMID 24893334

The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-lalpha (HIF-1alpha) and inhibits HIF-1-mediated transcription