腫瘍熱
WordNet
- a rise in the temperature of the body; frequently a symptom of infection (同)febrility, febricity, pyrexia, feverishness
- intense nervous anticipation; "in a fever of resentment"
- highly excited; "a fevered imagination"
- an abnormal new mass of tissue that serves no purpose (同)tumour, neoplasm
PrepTutorEJDIC
- 〈U〉《しばしばa fever》(身体の異常な)『熱』,発熱 / 〈U〉『熱病』 / 〈U〉〈C〉(…に対する)『興奮』,熱狂《+『for』+『名』》
- (比較変化なし)《名詞の前にのみ用いて》熱のある,熱病にかかった / 熱にうかされたような,興奮した / (憎しみなどが)異常に強い
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English Journal
- Vascular endothelial growth factor polymorphisms affect gene expression and tumor aggressiveness in patients with breast cancer.
- Sa-Nguanraksa D1, Kooptiwut S2, Chuangsuwanich T3, Pongpruttipan T3, Malasit P4, O-Charoenrat P5.Author information 1Graduate Program in Immunology, Department of Immunology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.2Department of Physiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.3Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.4Dengue Hemorrhagic Fever Research Unit, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.5Division of Head-Neck and Breast Surgery, Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.AbstractVascular endothelial growth factor (VEGF) is one of the key modulators of angiogenesis. The highly polymorphic promoter and 5' untranslated region of VEGF have been associated with susceptibility to and aggressiveness of several types of cancer. To examine the functional role of VEGF polymorphisms at -634 and -1498 positions, VEGF mRNA and protein in breast cancer tissues were analyzed by quantitative polymerase chain reaction and immunohistochemistry. A dual-luciferase assay was performed to determine promoter activity. The VEGF-634CC genotype demonstrated the highest VEGF mRNA expression. High VEGF mRNA expression was correlated with a tumor size of >2 cm, the presence of lymphovascular invasion and the presence of axillary nodal metastasis. The promoter containing the -1498T/-634C haplotype exhibited the highest basal promoter activity. These findings suggest that the interaction between -1498T and -634C polymorphisms increases VEGF expression and is involved in breast cancer aggressiveness.
- Molecular medicine reports.Mol Med Rep.2014 Mar;9(3):1044-8. doi: 10.3892/mmr.2014.1890. Epub 2014 Jan 9.
- Vascular endothelial growth factor (VEGF) is one of the key modulators of angiogenesis. The highly polymorphic promoter and 5' untranslated region of VEGF have been associated with susceptibility to and aggressiveness of several types of cancer. To examine the functional role of VEGF polymorphisms a
- PMID 24401996
- A genomics approach to identify susceptibilities of breast cancer cells to "fever-range" hyperthermia.
- Amaya C, Kurisetty V, Stiles J, Nyakeriga AM, Arumugam A, Lakshmanaswamy R, Botez CE, Mitchell DC, Bryan BA.AbstractBACKGROUND: Preclinical and clinical studies have shown for decades that tumor cells demonstrate significantly enhanced sensitivity to "fever range" hyperthermia (increasing the intratumoral temperature to 42-45[degree sign]C) than normal cells, although it is unknown why cancer cells exhibit this distinctive susceptibility.
- BMC cancer.BMC Cancer.2014 Feb 11;14(1):81. [Epub ahead of print]
- BACKGROUND: Preclinical and clinical studies have shown for decades that tumor cells demonstrate significantly enhanced sensitivity to "fever range" hyperthermia (increasing the intratumoral temperature to 42-45[degree sign]C) than normal cells, although it is unknown why cancer cells exhibit this d
- PMID 24511912
- Do Proinflammatory Cytokine Levels Predict Serious Complication Risk of Infection in Pediatric Cancer Patients?
- Karakurt DG, Demirsoy U, Corapcioglu F, Oncel S, Karadogan M, Arisoy ES.Author information Department of Pediatric Oncology, Kocaeli University, Kocaeli, Turkey.AbstractDetermination of risk of severe bacterial infection complication in children with cancer is important to diminish the cost of hospitalization and therapy. In this study, children with cancer (leukemia excluded) were evaluated for risk of severe infection complication, success of therapy and the relation between clinical and inflammatory parameters during neutropenic fever attacks. Children who fulfilled the criteria of neutropenic fever with cancer were enrolled in the study. During admission, together with clinical and laboratory parameters; interleukin-6, interleukin-8, soluble tumor necrosis factor receptor II, and soluble interleukin 2 reseptor ve procalcitonin levels were detected. Empirical therapy was started with piperacillin/tazobactam and relation between the inflammatory cytokine levels and therapy response parameters were evaluated. The study population included 31 children and 50 neutropenic attacks were studied. In 48% of the attacks, absolute neutrophile count was >100/mm3 and infectious agents were shown microbiologically in 12% of the attacks. In the study group with piperacillin/tazobactam monotherapy, the success rate without modification was 58%. In the therapy modified group mean duration of fever, antibiotherapy and hospitalization were significantly longer than the group without modification. Inflammatory cytokines' levels during admission (interleukin-6, interleukin-8, soluble tumor necrosis factor reseptor II) were higher in patients with fever >3 days and in multiple regression analysis, it has been shown that they have a determinative role on fever control time. Other cytokines did not show any significant relationship with risk of severe bacterial infection complication and success of therapy.
- Pediatric hematology and oncology.Pediatr Hematol Oncol.2014 Feb 5. [Epub ahead of print]
- Determination of risk of severe bacterial infection complication in children with cancer is important to diminish the cost of hospitalization and therapy. In this study, children with cancer (leukemia excluded) were evaluated for risk of severe infection complication, success of therapy and the rela
- PMID 24499434
Japanese Journal
- 岩佐 悠平,岩下 拓司,市川 広直,三田 直樹,上村 真也,戸田 勝久,金山 知弘,宮崎 龍彦,清水 雅仁
- 日本消化器内視鏡学会雑誌 63(1), 52-60, 2021
- <p>78歳女性．抗AQP4抗体陽性視神経脊髄炎に対しプレドニゾロン５mgで加療されていた．発熱，右季肋部痛を認め，血液検査で肝胆道系酵素，炎症反応の高値と，好酸球数割合の上昇があり，腹部造影CTは胆管壁の肥厚，濃染を認めた．ERCで肝外胆管壁の不整を認め，胆道鏡では胆管壁の浮腫，凹凸はあったが，悪性所見は認めなかった．胆管生検，肝生検では胆管への好酸球浸潤を認めたため好酸球性胆管炎と …
- NAID 130007970923
- A Multicenter Study of Docetaxel at a Dose of 100 mg/m<sup>2</sup> in Japanese Patients with Advanced or Recurrent Breast Cancer
- Hirata Taizo,Taira Naruto,Matsuoka Junji,Doihara Hiroyoshi,Ozaki Shinji,Tabata Masahiro,Iwamoto Takayuki,Hinotsu Shiro,Hamada Akinobu,Motoki Takayuki,Nogami Tomohiro,Shien Tadahiko
- Internal Medicine, 2021
- … <p><b>Objective </b>This study examined the pharmacokinetics, safety and anti-tumor activity of docetaxel at a dose of 100 mg/m<sup>2</sup> … The common AEs were neutropenia, thrombocytopenia, alopecia, rash, diarrhea, neuropathy (sensory), fatigue, nausea, fever, hypoalbuminemia, ALT increased, constipation, and taste alteration. …
- NAID 130007940000
- Adult-onset Still's disease with macrophage activation syndrome diagnosed and treated based on cytokine profiling: a case-based review
- Goda Ken,Kenzaka Tsuneaki,Hoshijima Masahiko,Yachie Akihiro,Akita Hozuka
- Rheumatology International 40(1), 145-152, 2020-01
- … Herein, we present the case of a 21-year-old woman admitted with a high fever, lasting for over 1 month, who did not fulfill the Yamaguchi criteria. … In addition, we predicted the occurrence of macrophage activation syndrome by a characteristic increase in the soluble tumor necrosis factor receptor II level, which allowed a timely intervention for this malicious complication. …
- NAID 120006786955
★リンクテーブル★
[★]
- 英
- malignant fever
- 同
- 腫瘍熱 tumor fever
- 関
- 発熱
[★]
- 英
- tumor fever
- 関
- 悪性熱
[★]