WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
an enzyme of pancreatic origin; catalyzes the hydrolysis of proteins to smaller polypeptide units

PrepTutorEJDIC

=sense organ / 受信装置

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1. Mast cell-derived mediators
2. 止血の概要 overview of hemostasis
3. 急性膵炎の発症機序 pathogenesis of acute pancreatitis
4. コレシストキニンの生理学 physiology of cholecystokinin
5. 肥満細胞：増殖・分化、識別、および生理学的役割 mast cells development identification and physiologic roles

English Journal

Sex-related differences in SLIGRL-induced pruritus in mice.

Yamaura K1, Tomono A2, Suwa E2, Ueno K2.Author information 1Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan. Electronic address: yamaura@chiba-u.jp.2Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.AbstractAIMS: Pruritus is a common symptom of skin diseases, and is associated with impaired sleep quality and a considerable reduction in the patient's quality of life. Recently, it was reported that there are sex-specific differences in scratching behavior in chronic pruritus patients. Namely, female chronic pruritus patients scratch more and have significantly more scratch lesions than male patients. However, few animal studies have examined sex-related differences in scratching behavior. Thus, the present work investigated sex-related differences in animal pruritus using pruritogens, which are often used to create experimental animal models of itching.
Life sciences.Life Sci.2014 Jan 14;94(1):54-7. doi: 10.1016/j.lfs.2013.10.036. Epub 2013 Nov 14.
AIMS: Pruritus is a common symptom of skin diseases, and is associated with impaired sleep quality and a considerable reduction in the patient's quality of life. Recently, it was reported that there are sex-specific differences in scratching behavior in chronic pruritus patients. Namely, female chro
PMID 24239643

Protease-activated receptor 2 signalling pathways: a role in pain processing.

Bao Y, Hou W, Hua B.Author information Guang'anmen Hospital, China Academy of Chinese Medical Science, Department of Oncology , Beixiange 5, Xicheng District, Beijing 100053 , China +86 10 88001221 ; +86 10 88001430 ; baoyanju@126.com ; houwei1964@sohu.com ; huabaojin@sohu.com.AbstractIntroduction: Pain is a complex biological phenomenon that includes intricate neurophysiological, behavioural, psychosocial and affective components. Despite decades of pain research, many patients continue suffering from chronic pain that may be refractory to current medical regimens. Accumulating evidence has indicated an important role of protease-activated receptor 2 (PAR2) in the pathogenesis of pain, including inflammation, neuropathic and cancer pain. Areas covered: In this review, the role of the PAR2 signalling pathway in pain processes, basic mechanism of PAR2 activation and expression of PAR2 in the nervous system is covered. Furthermore, intracellular signalling pathways that are activated by PAR2 are also described. Expert opinion: The role of PAR2 in pain processing is becoming increasingly clear, and although causal implication remains to be established, PAR2 activation has been observed in several disease model systems. Since PAR2 is activated after nerve injury as well as by trypsin and related serine proteases, and PAR2 plays an important role in pain development and maintenance, exploring PAR2 and its corresponding signalling pathways will provide unfathomable knowledge in understanding the molecular basis of pain. This will also help to identify new targets for pharmacological intervention; however, in the context of potential PAR2-directed therapies, several aspects should be clarified.
Expert opinion on therapeutic targets.Expert Opin Ther Targets.2014 Jan;18(1):15-27. doi: 10.1517/14728222.2014.844792. Epub 2013 Oct 23.
Introduction: Pain is a complex biological phenomenon that includes intricate neurophysiological, behavioural, psychosocial and affective components. Despite decades of pain research, many patients continue suffering from chronic pain that may be refractory to current medical regimens. Accumulating
PMID 24147628

Proteinase-Activated Receptors Differentially Modulate In Vitro Invasion of Human Pancreatic Adenocarcinoma PANC-1 Cells in Correlation With Changes in the Expression of CDC42 Protein.

Segal L, Katz LS, Lupu-Meiri M, Shapira H, Sandbank J, Gershengorn MC, Oron Y.Author information From the *Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel; †Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD; ‡Institute of Pathology, Central Lab, Maccabi, Rehovot, Israel; and §Assaf Harofe Hospital Institute of Pathology and the Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.AbstractOBJECTIVES: Proteinase-activated receptor-1 (PAR-1) and PAR-2 have been associated with increased invasiveness and metastasis in human malignancies. The role of PAR-3 has been less investigated. We examined the role of PARs in a human pancreatic adenocarcinoma PANC-1 cell line phenotype in vitro.
Pancreas.Pancreas.2014 Jan;43(1):103-8. doi: 10.1097/MPA.0b013e31829f0b81.
OBJECTIVES: Proteinase-activated receptor-1 (PAR-1) and PAR-2 have been associated with increased invasiveness and metastasis in human malignancies. The role of PAR-3 has been less investigated. We examined the role of PARs in a human pancreatic adenocarcinoma PANC-1 cell line phenotype in vitro.MET
PMID 23921961

Japanese Journal

Journal of Osaka Dental University

SHINTANI Tsuguo,DOMAE Eisuke,YOSHIKAWA Yoshihiro,KAMADA Aiko,IKEO Takashi
Journal of Osaka Dental University 53(1), 9-14, 2019
… Recent reports suggest that trypsin and the trypsin‐like enzyme tryptase modulate the ability of macrophages to polarize to the M2a phenotype. … Trypsin also potentiates monocytes to differentiate into fibrocytes resulting in enhanced wound healing. … In this study we examined the effect of trypsin on the ability of the mouse macrophage cell line RAW264.7 to differentiate into osteoclasts. …
NAID 130007682998

The effect of calprotectin on TSLP and IL-25 production from airway epithelial cells

Kato Tomohisa,Kouzaki Hideaki,Matsumoto Koji,Hosoi Junichi,Shimizu Takeshi
Allergology International 66(2), 281-289, 2017
… Alternaria, house dust mites, protease from Staphylococcus aureus, papain, trypsin, polyinosinic:polycytidylic acid and lipopolysaccharide stimulated calprotectin production in the cultured NHBE cells. …
NAID 130005628250

ERCP後膵炎の発症，重症化に関する膵管内圧とプロテアーゼ活性化受容体PAR-2のかかわり

明石隆吉
膵臓 30(6), 783-795, 2015
急性膵炎の発症，重症化に関して，プロテアーゼ（トリプシン）活性化受容体-2（PAR-2）は膵管口閉塞，膵管内圧負荷の有無により真逆の反応を呈する．ERCP関連手技により膵管上皮，膵腺房細胞が侵襲をうけると，トリプシンの活性化によりERCP後膵炎（PEP）が発症する．同時にPAR-2が膵管上皮，膵腺房細胞に発現し，膵管上皮からは膵液分泌を促すことで膵管内の毒物の洗浄を行い，膵の更なるダメージの回避を …
NAID 130005126569