WordNet

(physical chemistry) a sample of matter in which substances in different phases are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system generating hydrogen peroxide"
instrumentality that combines interrelated interacting artifacts designed to work as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small computer"
a group of independent but interrelated elements comprising a unified whole; "a vast system of production and distribution and consumption keep the country going" (同)scheme
a complex of methods or rules governing behavior; "they have to operate under a system they oppose"; "that language has a complex system for indicating gender" (同)system of rules
a group of physiologically or anatomically related organs or parts; "the body has a system of organs for digestion"
a procedure or process for obtaining an objective; "they had to devise a system that did not depend on cooperation"
the living body considered as made up of interdependent components forming a unified whole; "exercise helped him get the alcohol out of his system"

PrepTutorEJDIC

〈C〉(関連した部分から成る)『体系』,系統,組織[網],装置 / 〈C〉(教育・政治などの)『制度』,機構;《the~》体制 / 〈C〉(思想・学問などの)『体系』,学説 / 〈C〉(…の)『方法』,方式,やり方《+of doing》 / 〈U〉正しい方針(筋道,順序) / 〈U〉《the~》(身体の)組織,系統 / 〈U〉《the~,one's~》身体,全身

UpToDate Contents

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1. 心筋における興奮収縮連関excitation contraction coupling in myocardium [show details]
…protein tropomyosin, which lies in the groove of the thin filament formed by the two F-actin strands. Tropomyosin is closely associated with three other proteins, troponin I, troponin T, and troponin C. It …
2. 肥大型心筋症：遺伝子変異および臨床遺伝子検査hypertrophic cardiomyopathy gene mutations and clinical genetic testing [show details]
… Mutations in the troponin I, troponin T, and alpha-tropomyosin genes account for only 5 to 10 percent of… late onset disease is an interaction with genetic polymorphisms of the renin-angiotensin-aldosterone system (RAAS) . Approximately 40 percent of adults under the age of 50 with the cardiac myosin binding …
3. 拡張型心筋症の遺伝学genetics of dilated cardiomyopathy [show details]
… cardiac troponin T (TNNT2), titin (TTN), alpha-tropomyosin (TPM1), and cardiac troponin C (TNNC1) .… in the development of conduction system disease and arrhythmia development, but usually occurs after conduction system disease (and at times years later).…
4. 成人の孤立性左室心筋緻密化障害：臨床症状および診断isolated left ventricular noncompaction in adults clinical manifestations and diagnosis [show details]
… cardiac troponin T (TNNT2), troponin I (TNN13), cardiac myosin binding protein C (MYBPC3), SCN5A, SNTA1, PRDM16, and tropomyosin 1 (TPM1) .… blood from the ventricular cavity without evidence of communication to the epicardial coronary artery system. As discussed below, criteria for the extent of noncompaction have been developed to help distinguish …
5. 肥大型心筋症：自然経過および予後hypertrophic cardiomyopathy natural history and prognosis [show details]
… cardiac troponin T, and alpha tropomyosin genes in more than 45 percent of cases), elderly-onset HCM is in some series associated with mutations in the cardiac myosin binding protein-C, troponin I,… Progressive conduction system disease requiring pacemaker implantation is common with PRKAG2 mutations ,…

English Journal

TPM3 deletions cause a hypercontractile congenital muscle stiffness phenotype.

Donkervoort S1, Papadaki M2, de Winter JM3, Neu MB1, Kirschner J4, Bolduc V1, Yang ML5, Gibbons MA6, Hu Y1, Dastgir J1, Leach ME1,7, Rutkowski A8, Foley AR1, Krüger M9, Wartchow EP10, McNamara E11, Ong R11, Nowak KJ1, Laing NG12, Clarke NF13, Ottenheijm CA3, Marston SB2, Bönnemann CG1.
Annals of neurology.Ann Neurol.2015 Sep 29. doi: 10.1002/ana.24535. [Epub ahead of print]
OBJECTIVE: Mutations in TPM3, encoding Tpm3.12, cause a clinically and histopathologically diverse group of myopathies characterized by muscle weakness. We report two patients with novel de novo Tpm3.12 single glutamic acid deletions at positions ΔE218 and ΔE224, resulting in a significant hyperco
PMID 26418456

Regulation of structure and function of sarcomeric actin filaments in striated muscle of the nematode Caenorhabditis elegans.

Ono S1.
Anatomical record (Hoboken, N.J. : 2007).Anat Rec (Hoboken).2014 Sep;297(9):1548-59. doi: 10.1002/ar.22965.
The nematode Caenorhabditis elegans has been used as a valuable system to study structure and function of striated muscle. The body wall muscle of C. elegans is obliquely striated muscle with highly organized sarcomeric assembly of actin, myosin, and other accessory proteins. Genetic and molecular b
PMID 25125169

EF-hand proteins and the regulation of actin-myosin interaction in the eutardigrade Hypsibius klebelsbergi (tardigrada).

Prasath T1, Greven H, D'Haese J.
Journal of experimental zoology. Part A, Ecological genetics and physiology.J Exp Zool A Ecol Genet Physiol.2012 Jun;317(5):311-20. doi: 10.1002/jez.1724.
Many tardigrade species resist harsh environmental conditions by entering anhydrobiosis or cryobiosis. Desiccation as well as freeze resistance probably leads to changes of the ionic balance that includes the intracellular calcium concentration. In order to search for protein modifications affecting
PMID 25363580