tripelennamine

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tripelennamine hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/01 17:26:55」(JST)

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Tripelennamine

Systematic (IUPAC) name
N,N-dimethyl-N-(phenylmethyl)-N-pyridin-2-ylethane-1,2-diamine
Clinical data
AHFS/Drugs.com	Multum Consumer Information
MedlinePlus	a601044
Legal status	℞ (Prescription only)
Routes of administration	Oral, Intravenous
Pharmacokinetic data
Metabolism	Hepatic hydroxylation and glucuronidation
Biological half-life	4-6 hours
Excretion	Renal
Identifiers
CAS Number	91-81-6 Y 154-69-8 (monohydrochloride) 22306-05-4 (hydrochloride) 57116-36-6 (maleate) 6138-56-3 (citrate)
ATC code	D04AA04 R06AC04
PubChem	CID: 5587
IUPHAR/BPS	7318
DrugBank	DB00792 Y
ChemSpider	5385 Y
UNII	3C5ORO99TY Y
KEGG	D08645 Y
ChEMBL	CHEMBL1241 Y
Chemical data
Formula	C16H21N3
Molecular mass	255.358 g/mol
SMILES CN(C)CCN(CC1=CC=CC=C1)C2=NC=CC=C2
InChI InChI=1S/C16H21N3/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15/h3-11H,12-14H2,1-2H3 Y Key:UFLGIAIHIAPJJC-UHFFFAOYSA-N Y
Y (what is this?)  (verify)

Tripelennamine (sold as Pyribenzamine by Novartis) is a drug that is used as an antipruritic and first-generation antihistamine. It can be used in the treatment of asthma, hay fever, rhinitis and urticaria, but is now less common as it has been replaced by newer antihistamines. It is a member of the pyridine and ethylenediamine classes.

Medical uses

Where and when it is/was in common use, tripelennamine is used much like other mildly-anticholinergic antihistamines for treating conditions of the upper respiratory tract arising from illnesses and hay fever. It can be used alone or in combination with other agents to have the desired effect. Cough medicine of the general formula tripelennamine + codeine/dihydrocodine/hydrocodone ± expectorant ± decongestant(s) is quite popular where available. One example is the line of Pyribenzamine Cough Syrups which contains codeine and with and without decongestants listed in the 1978 Physicians' Desk Reference; the codeine-tripelennamine synergy is well-known and does make such mixtures more useful for their intended purposes.

Side effects

Tripelennamine is mildly sedating. Other side effects can include irritation, dry mouth, nausea, and dizziness.

Recreational use

Tripelennamine by itself is a primary euphoriant manifesting anxiolytic, sedative, dopaminergic, and quasi-tricyclic-anti-depressant actions; unlike diphenhydramine and the like, there is little to no anticholinergic action (given by one source as 7 per cent the muscarinic blocking power of atropine compared to 58 per cent for diphenhydramine and 25 per cent for chlorpheniramine), making the euphoria subjectively different from that of orphenadrine and its relatives as well as dexchlorpheniramine (Polaramine) and other alkylamine antihistamines. Anticholinergics like scopolamine, trihexyphenidyl, dicycloverine, orphenadrine, diphenhydramine, benztropine, cyclobenzaprine, etc. produce a characteristic mild to moderate euphoria by this mechanism, and alkylamines have elements of both. The relatively rapid onset of action by any route of administration is also part of the appeal.

Tripelennamine is used also for its tranquillizing effects, which are stronger than those of its close chemical relative pyrilamine, which is used in OTC day-time sedatives such as Compoz in many countries.

The most common recreational use of tripelennamine is as a potentiator of narcotic analgesics. It both strengthens the opioid effects overall and changes the side effect profile of the drug in question by adding warmth and other qualities. The potentiating effect is also used clinically to increase the effectiveness of a given dose of painkiller; the most commonly used for this purpose are hydroxyzine, doxylamine, phenyltoloxamine, orphenadrine, cyclizine, meclozine, promethazine, and chlorpheniramine. The above list includes drugs from all five major families of first-generation antihistamines, which attain a similar objective by somewhat differing means.

Tripelennamine is sometimes abused recreationally in combination with the benzomorphan class synthetic opioid pentazocine (Fortral, Talacen, Talwin) in a mixture known as "T's & Blues", or morphine ("Blue Velvet"), by preparing an injection containing both agents; heroin may also be used like this. The local anesthetic effects of the antihistamine manifest in the case of intramuscular and subcutaneous injections. The US manufacturers of Talwin began adding naloxone to the tablets in the late 1970s as the practice of Ts and Blues spread—injecting a solution made from the pills delivers the antagonist which does not enter the system in significant amounts if the pills are swallowed. This changed the name of the product in question to Talwin NX. Talwin PX, available in Canada, and some other US versions as well as a large majority of pentazocine used in other countries does not contain the antagonist.

Tripelennamine is also used orally with the aforementioned drugs as well as paregoric, opium in all its forms including powdered opium and DTO (laudanum), narcotic cough syrups containing codeine and its derivatives, and analgesic preparations containing opioids with much the same impact, albeit taking longer to develop etc.

This use of tripelennamine with mixed agonist–antagonist opioids such as pentazocine, phenazocine, dezocine, butorphanol (Stadol), buprenorphine (Temgesic, Subutex), nalbuphine (Nubain) and others has results that make it appear that the antihistamine changes the receptor-activation profile of these drugs in a way that makes them more euphoric, but it is unknown if tripelennamine operates in this way in a true, literal sense or if increased dopamine levels counteract the dysphoric action of antagonists and drugs affecting the kappa opioid receptor in particular, and to an unclear extent pure agonists with dysphoria-inducing metabolites such as pethidine (Dolantin, Demerol) and its relatives. The relatively small degree of additive anticholinergic action make non-parenteral analogues of Blue Velvet using opium-belladonna combinations feasible and all the more euphoric. Tripelennamine and drugs of the same type of course do not counteract the effects of the naloxone which is added to pentazocine tablets in some countries to discourage injection.

It is dangerous to combine an opiate with a sedating antihistamine via injection, although the use of antihistamines (usually by mouth) to reduce opioid requirements for pain relief is a well-known practice, which is done under medical supervision with tripelennamine, as well as hydroxyzine, cyclizine, promethazine, diphenhydramine, phenindamine, orphenadrine, meclozine, chlorpheniramine, cyproheptadine and others; this method is doubly useful when used with opioids which release a great deal of histamine when administered and therefore cause itching, redness of skin and other histamine-related effects.

Like many of the first-generation antihistamines of the ethanolamine and alkylamine classes, tripelennamine and other members of its chemical class (ethylenediamines) produces a marginal to moderate euphoria; triepelennamine has a euphoriant effect with a relatively rapid onset and up to eight hours in duration.

The euphoric effect of tripelennamine makes these combinations more than the sum of their parts, and it is qualitatively and quantitatively different from that of the ethanolamine antihistamines such as diphenhydramine and orphenadrine in that there is much less anticholinergic impact—the mixing of opioids and anticholinergics is vividly illustrated by the combination drugs Skophedal (scopolamine, ephedrine, and eucodal (oxycodone)) and Twilight Sleep (scopolamine and morphine) which are/were used particularly for nerve pain and produce very deep analgesia and are profoundly powerful euphoriants . The alkylamine antihistamines, including brompheniramine (Dimetapp), chlorpheniramine (Chlor-Trimeton), and dexchlorpheniramine (Polaramine), are therefore in between the ethanolamines and the ethylenediamines in this respect. Anticholinergics change the dopamine to acetylcholine ratio in the CNS, whereas this is much less prominent with tripelennamine, which causes an increase in the absolute levels of dopamine by means of reuptake inhibition without a lot of effect on acetylcholine. The opioid-potentiating effects of other antihistamines such as hydroxyzine, cyclizine etc. appear to be directly due to additive sedation, and promethazine also has metabolic effects on codeine and the like, namely increasing the percentage of codeine that the liver converts to morphine in most people.

Pharmacology

Tripelennamine acts primarily as an antihistamine, or H₁ receptor antagonist. It has little to no anticholinergic activity. In addition to its antihistamine properties, tripelennamine also acts as a weak serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). Because of its SRI properties, tripelennamine was used as the basis for the development of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine (Luvox).

History

Tripelennamine was first synthesized in 1946 by Carl Djerassi, working in the laboratory of Charles Huttrer at Ciba, shortly after Djerassi got his B.S. It was his first patent.

See also

• Chloropyramine
• Mepyramine
• Pheniramine

References

UpToDate Contents

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English Journal

• Single-step multiresidue determination of ten multiclass veterinary drugs in pork, milk, and eggs using liquid chromatography with tandem mass spectrometry.

• Park JA1, Zhang D1, Kim DS1, Kim SK1, Cho KS1, Jeong D1, Shim JH2, Kim JS1, El-Aty AM1,3, Shin HC1.
• Journal of separation science.J Sep Sci.2015 May 29. doi: 10.1002/jssc.201500501. [Epub ahead of print]
• A multiclass, multiresidue determination method is reported for the detection of ten veterinary drugs, including scopolamine, metoclopramide, acriflavine, berberine, tripelennamine, diphenhydramine, acrinol, triamcinolone, loperamide, and roxithromycin in pork, milk, and eggs. The method involves a
• PMID 26033853

• Septic arthritis in intravenous drug abusers: a historical comparison of habits and pathogens.

• Peterson TC1, Pearson C2, Zekaj M2, Hudson I1, Fakhouri G2, Vaidya R3.
• The Journal of emergency medicine.J Emerg Med.2014 Dec;47(6):723-8. doi: 10.1016/j.jemermed.2014.06.059. Epub 2014 Oct 2.
• BACKGROUND: Intravenous drug abuse (IVDA) is a common problem; there were more than 16 million users worldwide in 2008. Numerous reports highlight the infectious skeletal complication associated with IVDA.OBJECTIVE: To determine septic arthritis pathogens in IVDA in a U.S. hospital and compare the c
• PMID 25282119

• HPLC method for identification and quantification of three active substances in a dermatological preparation--Viosept ointment.

• Podolska M, Kulik A, Białecka W, Kwiatkowska-Puchniarz B, Mazurek A.
• Acta poloniae pharmaceutica.Acta Pol Pharm.2014 Sep-Oct;71(5):709-19.
• The study was aimed at developing a HPLC method to identify and quantify domiphen bromide, tripelennamine hydrochloride and clioquinol in Viosept ointment. The tested substances were successfully separated using Inertsil ODS-3 (250 x 4.6 mm, 5 μm) as a stationary phase and a gradient elution. Detec
• PMID 25362799

Japanese Journal

• On theMechanisms Underlying Histamine Induction of Gastric Mucosal Lesions in Rats With Partial Gastric Vascular Occlusion

• AMAGASE Kikuko,OKABE Susumu
• Journal of pharmacological sciences 92(2), 124-136, 2003-06-01
• … Both antagonists of histamine H2-receptors (roxatidine and famotidine) and H1-receptors (epinastine and tripelennamine) significantly inhibited lesion formation at doses that did not inhibit acid secretion. … Combined treatment of tripelennamine and famotidine synergistically inhibited lesion formation. …
• NAID 10011232233

• Evaluation of the Histamine H_1-Antagonist-Induced Place Preference in Rats

• SUZUKI Tsutomu,MORI Tomohisa,TSUJI Minoru,NOMURA Mutsuko,MISAWA Miwa,ONODERA Kenji
• The Japanese journal of pharmacology 81(4), 332-338, 1999-12-01
• … The place preferences by some histamine H1 antagonists, such as tripelennamine, optical isomers of chlorpheniramine (dl-, d- and l-forms) and pyrilamine, in rats were evaluated with the conditioned place preference paradigm. … In the present study, tripelennamine and all of the optical isomers of chlorpheniramine, but not pyrilamine, produced a significant place preference. …
• NAID 10008197486

• ラット後躯自己血液潅流標本における血管拡張反応の薬理学的特性

• 西村 昌数,スー チェ,リー トニーJ. -F.
• 帯広畜産大学学術研究報告. 自然科学 19(4), 179-190, 1996-06-26
• … infusion of H1-antihistaminics, d, 1-chlorpheniramine and tripelennamine, but not by pyrilamine. … However, d, 1-chlorpheniramine and tripelennamine, but not pyrilamine, are known to inhibit norepinephrine uptake, and were mimicked by cocaine in their antidilator activity. …
• NAID 110006458074

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リンク元	「クロロセン」「トリペレナミン」
拡張検索	「tripelennamine hydrochloride」

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chlorothen

• 抗ヒスタミン薬

• H1受容体の拮抗薬
• tripelennamineよりも毒性が弱く、効力が高い (参考1)
• アレルギー性鼻炎、血管運動性鼻炎、アレルギー性結膜炎、蕁麻疹、血管性浮腫、血液や血漿に対するアレルギー反応、皮膚描画症 (参考1)

参考

• 1.

http://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+5183

「トリペレナミン」

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tripelennamine、tripelennamine hydrochloride

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-tripelennamine

「tripelennamine hydrochloride」

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• 塩酸トリペレナミン

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tripelennamine