triglyceride storage disease

トリグリセリド蓄積病？

WordNet

1. an impairment of health or a condition of abnormal functioning
2. (computer science) the process of storing information in a computer memory or on a magnetic tape or disk
3. the act of storing something
4. the commercial enterprise of storing goods and materials
5. caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological
6. glyceride occurring naturally in animal and vegetable tissues; it consists of three individual fatty acids bound together in a single large molecule; an important energy source forming much of the fat stored by the body

PrepTutorEJDIC

1. (体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
2. 女性の話術芸人 =diseur
3. (倉庫などに)貯蔵すること,保管 / 貯蔵所,倉庫 / 保管料
4. 病気にかかった / 病的な,不健全な(morbid)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. アルコール​性脂肪性肝炎​および​アルコール​性肝硬変​の​臨床症状​および​診断​ clinical manifestations and diagnosis of alcoholic fatty liver disease and alcoholic cirrhosis
• 2. HDL​代謝​および​HDL​コレステロール​値異常​の​患者​に​対​する​アプローチ​ hdl metabolism and approach to the patient with abnormal hdl cholesterol levels
• 3. 全身疾患​と​関連​した​遺伝性​ニューロパチー​ hereditary neuropathies associated with generalized disorders
• 4. 高​トリグリセリド​血症患者​に​対​する​アプローチ​ approach to the patient with hypertriglyceridemia
• 5. 成人​における​非​アルコール​性脂肪性肝疾患​（​NAFLD​）​の​疫学​、​臨床的特徴​、​および​診断​ epidemiology clinical features and diagnosis of nonalcoholic fatty liver disease in adults

English Journal

• 5α-reductase type 1 deficiency or inhibition predisposes to insulin resistance, hepatic steatosis, and liver fibrosis in rodents.

• Livingstone DE1, Barat P2, Di Rollo EM2, Rees GA2, Weldin BA2, Rog-Zielinska EA2, MacFarlane DP2, Walker BR2, Andrew R2.
• Diabetes.Diabetes.2015 Feb;64(2):447-58. doi: 10.2337/db14-0249. Epub 2014 Sep 19.
• 5α-Reductase type 1 (5αR1) catalyses A-ring reduction of androgens and glucocorticoids in liver, potentially influencing hepatic manifestations of the metabolic syndrome. Male mice, homozygous for a disrupted 5αR1 allele (5αR1 knockout [KO] mice), were studied after metabolic (high-fat diet) and
• PMID 25239636

• Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease.

• Dongiovanni P1, Petta S, Maglio C, Fracanzani AL, Pipitone R, Mozzi E, Motta BM, Kaminska D, Rametta R, Grimaudo S, Pelusi S, Montalcini T, Alisi A, Maggioni M, Kärjä V, Borén J, Käkelä P, Di Marco V, Xing C, Nobili V, Dallapiccola B, Craxi A, Pihlajamäki J, Fargion S, Sjöström L, Carlsson LM, Romeo S, Valenti L.
• Hepatology (Baltimore, Md.).Hepatology.2015 Feb;61(2):506-14. doi: 10.1002/hep.27490.
• Excess hepatic storage of triglycerides is considered a benign condition, but nonalcoholic steatohepatitis (NASH) may progress to fibrosis and promote atherosclerosis. Carriers of the TM6SF2 E167K variant have fatty liver as a result of reduced secretion of very-low-density lipoproteins (VLDLs). As
• PMID 25251399

• In vivo 2H2O administration reveals impaired triglyceride storage in adipose tissue of insulin-resistant humans.

• Allister CA1, Liu LF2, Lamendola CA2, Craig CM2, Cushman SW3, Hellerstein MK1, McLaughlin TL2.
• Journal of lipid research.J Lipid Res.2015 Feb;56(2):435-9. doi: 10.1194/jlr.M052860. Epub 2014 Nov 23.
• Indirect evidence suggests that impaired triglyceride storage in the subcutaneous fat depot contributes to the development of insulin resistance via lipotoxicity. We directly tested this hypothesis by measuring, in vivo, TG synthesis, de novo lipogenesis (DNL), adipocyte proliferation, and insulin s
• PMID 25418322

Japanese Journal

• Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes

• Hayashi Yasuhiro,Suemitsu Erina,Kajimoto Kazuaki,Sato Yusuke,Akhter Afsana,Sakurai Yu,Hatakeyama Hiroto,Hyodo Mamoru,Kaji Noritada,Baba Yoshinobu,Harashima Hideyoshi
• Molecular Therapy - Nucleic Acids 3, e154, 2014-03-18
• … Here, we introduce a liver-specific nonviral small interfering RNA (siRNA) delivery system into rapid and efficient characterization of hepatic gene targets in metabolic disease mice. … The comparative transcriptome analysis in liver between KKAy diabetic and normal control mice demonstrated that the expression of monoacylglycerol O-acyltransferase 1 (Mogat1), an enzyme involved in triglyceride synthesis and storage, was highly elevated during the disease progression. …
• NAID 120005512021

• Adipose tissue inflammation and ectopic lipid accumulation [Review]

• , ,
• Endocrine Journal 59(10), 849-857, 2012
• … Obesity may be viewed as a chronic low-grade inflammatory disease as well as a metabolic disease. … On the other hand, storing excessive energy as triglyceride is also a fundamental function of adipose tissue. … Recent evidence suggests that reduced lipid storage in obese adipose tissue contributes to ectopic lipid accumulation in non-adipose tissues such as the liver, skeletal muscle, and pancreas, where lipotoxicity impairs their metabolic functions. …
• NAID 130004770327

• Cardiorespiratory Fitness and Metabolic Markers in Healthy Young Adult Men

• , , , , , , ,
• Journal of Physical Therapy Science 23(6), 845-849, 2011
• … The metabolic markers, HDL-cholesterol, triglyceride, fasting glucose, fasting insulin and leptin, were also measured, as well as and body composition, body height, body weight, percentage fat mass, waist circumference, and hip circumference. … [Results] Our results show that lower cardiorespiratory fitness was significantly associated with higher storage of fat, lipid markers of developing atherosclerosis, and circulating leptin levels. …
• NAID 130004431702

Related Links

• Triglyceride storage disease. A report of two affected children ...

Triglyceride storage disease. A report of two affected children associated with neurological abnormalities. Galton DJ, Reckless JP, Taitz LS. Two children are described with congenital abnormalities (microcephaly, nystagmus, deafness, ...

---

★リンクテーブル★

関連記事	「disease」「storage」「triglycerides」「triglyceride」

「disease」

　　[★]

• n.

疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)

特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)

• something that is very wrong with people's attitudes, way of life or with society.

関

ail、ailment、disease entity、disorder、ill、illness、malady、sick、sickness

• 注意

disease ≠ illness ≠ disorder

　 　 　

「storage」

　　[★]

• n.

• 貯蔵

関

pool、pooling、preservation、preserve、reserve、store

　 　 　 　

「triglycerides」

　　[★] トリアシルグリセロール TG

「triglyceride」

　　[★] トリアシルグリセロール