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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/12/06 16:44:26」(JST)

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Metrifonate (INN) or trichlorfon (USAN) is an irreversible organophosphate acetylcholinesterase inhibitor.^[1] It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate (DDVP).

It is used as an insecticide.

It can be used to treat schistosomiasis caused by Schistoma haematobium but is no longer commercially available.^[2]

It has been proposed for use in treatment of Alzheimer's disease, but use for that purpose is not currently recommended.^[3]

References

^ "NLH - Neurological Conditions - Metrifonate for Alzheimer's disease".
^ Ross A.G.P., Bartley P.B., Sleigh A.C., Olds G.R., Li Y., Williams G.M., and McManus D.P. (2002). "Schistosomiasis". The New England Journal of Medicine 346 (16): 1212–1220. doi:10.1056/NEJMra012396. PMID 11961151.
^ López-Arrieta J, Schneider L (2008). López-Arrieta, Jess, ed. "Metrifonate for Alzheimer's disease". Cochrane Database of Systematic Reviews (1): CD003155. doi:10.1002/14651858.CD003155.pub3. PMID 16625573.

This antiinfective drug article is a stub. You can help Wikipedia by expanding it.

English Journal

Development of direct competitive biomimetic immunosorbent assay based on quantum dot label for determination of trichlorfon residues in vegetables.

Liu Q1, Jiang M1, Ju Z2, Qiao X3, Xu Z4.
Food chemistry.Food Chem.2018 Jun 1;250:134-139. doi: 10.1016/j.foodchem.2017.12.079. Epub 2018 Jan 3.
PMID 29412902

Monogenean parasites infect ornamental fish imported to Australia.

Trujillo-González A1, Becker JA2, Vaughan DB3, Hutson KS3.
Parasitology research.Parasitol Res.2018 Feb 9. doi: 10.1007/s00436-018-5776-z. [Epub ahead of print]
PMID 29427156

Transcriptome analysis of Rana chensinensis liver under trichlorfon stress.

Ma Y1, Li B1, Ke Y2, Zhang Y3, Zhang Y4.
Ecotoxicology and environmental safety.Ecotoxicol Environ Saf.2018 Jan;147:487-493. doi: 10.1016/j.ecoenv.2017.09.016. Epub 2017 Sep 14.
PMID 28910747

Japanese Journal

Delayed Polyneuropathy Induced by Organophosphate Poisoning

Kobayashi Shunsuke,Okubo Reiko,Ugawa Yoshikazu
Internal Medicine 56(14), 1903-1905, 2017
… <p>An 89-year-old man attempted suicide by ingesting a pesticide (trichlorfon). …
NAID 130005773818

等脚類Caecognathia coralliophilaに対するホルマリン,トリクロルホン,過酸化水素および硫酸銅の抗寄生虫効果(英文)

Thing Chong Yen,Ransangan Julian,Hatai Kishio
魚病研究 51(3), 125-127, 2016
… The effects of copper sulfate, formalin, trichlorfon, and hydrogen peroxide on the survival of <i>C. … Trichlorfon was found to be the most effective, killing the parasites within 24 h at 0.2 ppm. … Consequently, the toxicity of trichlorfon to tiger grouper was tested. … Fish were exposed to trichlorfon at 0.2 ppm for 24 h or 3.2 ppm for 60 min. No fish died in the experiment. …
NAID 130005420466

国内の養鶏場におけるワクモ<i>Dermanyssus gallinae</i>の市販殺虫剤に対する抵抗性出現

村野多可子,並木一男,椎名幸一 [他],安川久
日本獣医師会雑誌 68(8), 509-514, 2015
ワクモの駆除を目的とした市販のカーバメイト系製剤3剤，ピレスロイド系製剤1剤，有機リン系製剤3剤，ハエの駆除を目的とした市販のピレスロイド系製剤2剤，ピレスロイド系と有機リン系の合剤2製剤を用いて，2007～2013年の7年間ワクモの薬剤抵抗性出現について調査した．7年間の調査結果は2007～2010年の4年間と2011～2013年の3年間に分けて集計した．前半の4年間は1道1府30県139農場， …
NAID 130005099528

「トリクロルホン」

Metrifonate
Systematic (IUPAC) name
	(RS)-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Pharmacokinetic data
Half-life	3 hours
Identifiers
CAS number	52-68-6
ATC code	P02BB01 QP52AB01 QP53AF02
PubChem	CID 5853
ChemSpider	5644
UNII	DBF2DG4G2K
KEGG	C07971
ChEBI	CHEBI:6908
Synonyms	Trichlorphon
Chemical data
Formula	C4H8Cl3O4P
Mol. mass	257.436 g/mol
	SMILES COP(=O)(C(C(Cl)(Cl)Cl)O)OC InChI = 1/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3;
	InChI InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3; Key:NFACJZMKEDPNKN-UHFFFAOYSA-N ;
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　　[★]

英: trichlorfon
関: メトリホナート

[urlNLH_-_Neurological_Conditions_-_Metrifonate_for_Alzheimers_disease-1] "NLH - Neurological Conditions - Metrifonate for Alzheimer's disease".

[urlschistosomiasis-2] Ross A.G.P., Bartley P.B., Sleigh A.C., Olds G.R., Li Y., Williams G.M., and McManus D.P. (2002). "Schistosomiasis". The New England Journal of Medicine 346 (16): 1212–1220. doi:10.1056/NEJMra012396. PMID 11961151.

[3] López-Arrieta J, Schneider L (2008). López-Arrieta, Jess, ed. "Metrifonate for Alzheimer's disease". Cochrane Database of Systematic Reviews (1): CD003155. doi:10.1002/14651858.CD003155.pub3. PMID 16625573.

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案内

trichlorfon