triazolam

出典: meddic

トリアゾラム

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「a form of benzodiazepine (trade name Halcion) frequently prescribed as a sleeping pill; usually given to people who have trouble falling asleep」
Halcion

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/11/25 00:44:34」(JST)

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英文文献

  • Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo.
  • Henderson CJ1, McLaughlin LA1, Scheer N1, Stanley LA1, Wolf CR2.
  • Molecular pharmacology.Mol Pharmacol.2015 Apr;87(4):733-9. doi: 10.1124/mol.114.097394. Epub 2015 Feb 5.
  • The cytochrome P450-dependent mono-oxygenase system is responsible for the metabolism and disposition of chemopreventive agents, chemical toxins and carcinogens, and >80% of therapeutic drugs. Cytochrome P450 (P450) activity is regulated transcriptionally and by the rate of electron transfer from
  • PMID 25657337
  • Effects of menthol on the pharmacokinetics of triazolam and phenytoin.
  • Hoshino M1, Ikarashi N, Hirobe R, Hayashi M, Hiraoka H, Yokobori K, Ochiai T, Kusunoki Y, Kon R, Tajima M, Ochiai W, Sugiyama K.
  • Biological & pharmaceutical bulletin.Biol Pharm Bull.2015;38(3):454-60. doi: 10.1248/bpb.b14-00764. Epub 2015 Jan 14.
  • We have previously shown that menthol attenuates the anticoagulant effect of warfarin by increasing the expression levels of CYP3A and CYP2C in the liver. This study evaluated the effects of menthol on the pharmacokinetics of the CYP3A substrate triazolam and the CYP2C substrate phenytoin. Menthol w
  • PMID 25757928
  • 1,2,4-triazole derivatives as potential scaffold for anticonvulsant activity.
  • Kamboj VK, Verma PK, Dhanda A, Ranjan S1.
  • Central nervous system agents in medicinal chemistry.Cent Nerv Syst Agents Med Chem.2015;15(1):17-22.
  • The search for new anticonvulsant agent with more selectivity and lower toxicity continues to be an area of rigorous investigation in medicinal chemistry. Epilepsy is a chronic disorder of brain whose treatment consists of controlling seizures with antiepileptic drugs that very often related with si
  • PMID 25675400

和文文献

  • Effects of Menthol on the Pharmacokinetics of Triazolam and Phenytoin
  • , , , , , , , , , , ,
  • Biological and Pharmaceutical Bulletin advpub(0), 2015
  • … This study evaluated the effects of menthol on the pharmacokinetics of the CYP3A substrate triazolam and the CYP2C substrate phenytoin. … Twenty-four hours after the administration of menthol, triazolam was orally administered, and the plasma concentration was measured. … In addition, the CYP3A metabolic activity for triazolam and the CYP3A expression level in the liver were determined. …
  • NAID 130004872293
  • Effects of Menthol on the Pharmacokinetics of Triazolam and Phenytoin
  • , , [他], , , , , , , , ,
  • Biological and Pharmaceutical Bulletin 38(3), 454-460, 2015
  • … This study evaluated the effects of menthol on the pharmacokinetics of the CYP3A substrate triazolam and the CYP2C substrate phenytoin. … Twenty-four hours after the administration of menthol, triazolam was orally administered, and the plasma concentration was measured. … In addition, the CYP3A metabolic activity for triazolam and the CYP3A expression level in the liver were determined. …
  • NAID 130004872268
  • The Melatonin Receptor Agonist Is Effective for Free-Running Type Circadian Rhythm Sleep Disorder: Case Report on Two Sighted Patients
  • , , , , , ,
  • The Tohoku Journal of Experimental Medicine 234(2), 123-128, 2014
  • Triazolam was added from the day 25 to promote earlier sleep onset. …
  • NAID 130004691037

関連リンク

Triazolam comes as a tablet to take by mouth. It is usually taken as needed at bedtime, but not with or shortly after a meal. Triazolam may not work well if it is taken with food. Follow the directions on your prescription label carefully ...
Triazolam: Infórmate sobre efectos secundarios, dosis, precauciones y más en MedlinePlus ... Antes de tomar triazolam, dígales a su médico y a su farmacéutico si es alérgico al triazolam; a a otros medicamentos; o a cualquiera ...

関連画像

Triazolam Addiction TreatmentTriazolam (Halcion) – 0.25mgTriazolamHelp support Erowid by Becoming a Member triazolam 0.25 mg TabHalcion Halcion (triazolam) 0.25 mg


★リンクテーブル★
リンク元ベンゾジアゼピン系薬物」「トリアゾラム

ベンゾジアゼピン系薬物」

  [★]

benzodiazepine
セロトニン受容体作動薬

特徴

睡眠薬

  • 大脳辺縁系視床下部の抑制に基づく抗不安作用、抗緊張作用によるものであり、自然の睡眠に近い。つまり睡眠パターンをさほど変えない。

抗不安薬

作用機序

  • GABAA受容体のαサブユニットに結合し、Cl-の透過性を更新させる

副作用

睡眠薬

トリアゾラム
ミダゾラム:血漿半減期t1/2=1.9hr
  • 作用時間の長い薬剤を使用した場合、翌日のふらつき、薬効の持ち越しを起こしやすい
ジアゼパム:血漿半減期t1/2=43hr

離脱症候群

ICU.780
  • 長期連用後の中止により生じる。
  • 症状:不安、興奮、失見当識、高血圧、頻脈、幻覚、痙攣

相互作用

ベンゾジアゼピン系誘導体

拮抗薬



トリアゾラム」

  [★]

triazolam
アスコマーナカムリトントリアラムハルシオンハルラックパルレオンミンザイン


  • ベンゾジアゼピン系睡眠導入薬。





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