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a synthetic corticosteroid (trade names Aristocort or Aristopak or Kenalog) used as an anti-inflammatory agent (同)Aristocort, Aristopak, Kenalog

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/09/28 12:18:36」(JST)

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Triamcinolone (trade names Aristocort, Kenacort, Tri-Nasal, Triaderm, Azmacort, Trilone, Volon A, Tristoject, and Tricortone) is a long-acting synthetic corticosteroid given orally, by injection, inhalation, or as a topical ointment or cream.

Uses

Triamcinolone is used to treat several different medical conditions, such as eczema, psoriasis, arthritis, allergies, ulcerative colitis, lupus, sympathetic ophthalmia, temporal arteritis, uveitis, ocular inflammation, visualization during vitrectomy and the prevention of asthma attacks. It will not treat an asthma attack once it has already begun.^[1]^[2]^[3]

Prior to 2007 it was manufactured under the name Azmacort as a corticosteroid inhaler for asthma long-term care. The patent holder, Sanofi, sold it under the brand name Nasacort.

In 2010, TEVA and Perrigo launched the first generic inhalable triamcinolone.^[4]

Triamcinolone is used to alleviate infection-induced eczema in fungal skin infections in the combination drug of econazole/triamcinolone.

Triamcinolone acetonide is one of the ingredients of Ledermix - an endodontic (tooth's root canal) lotion used between sessions.

Forms

Different triamcinolone salts are available, including acetonide, benetonide, furetonide, hexacetonide and diacetate.

Triamcinolone acetonide is a more potent type of triamcinolone, being about eight times as effective as prednisone.

Side effects

Side effects of Triamcinolone include sore throat, nosebleeds, increased coughing, headache, and runny nose. White patches in the throat or nose indicate a serious side effect. Symptoms of an allergic reaction include rash, itch, swelling, severe dizziness, trouble breathing.^[5] An additional side effect for women is a prolonged menstrual cycle.

References

Aristocort (triamcinolone) topical cream

Kenalog (triamcinolone) IM injection

^ Triamcinolone - Drugs.com
^ Triamcinolone Inhalation - Drugs.com
^ Alcon Receives FDA Approval of Triesence Injectable Triamcinolone Suspension for Use in Eye Surgery - Drugs.com
^ Perrigo Announces Launch Of Generic Version Of Nasacort AQ - CBS Detroit
^ "Drugs and Treatments - Nasacort AQ Nasl - Patient Handout". WebMD. http://www.webmd.com/drugs/drug-16244-Nasacort+AQ.aspx?drugid=16244&drugname=Nasacort%20AQ. Retrieved 2008-03-24.

External links

Triamcinolone Topical | MedlinePlus
Triamcinolone (Topical Application Route) | MayoClinic

UpToDate Contents

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1. 関節内および軟部組織注射：注射剤の種類および投与頻度intraarticular and soft tissue injections what agents to inject and how frequently [show details]
…percent), triamcinolone hexacetonide (31 percent), and triamcinolone acetonide (22 percent) . Among the more commonly used glucocorticoids, there were regional differences, with triamcinolone acetonide preferred …
2. 成人における関節吸引または注射：手技および適応joint aspiration or injection in adults technique and indications [show details]
… patients with RA) were randomly assigned to be aspirated or not prior to injection of 20 mg of triamcinolone hexacetonide ; relapse of a joint effusion was noted in 23 percent of those who were aspirated versus …
3. 成人の関節リウマチへの初期治療initial treatment of rheumatoid arthritis in adults [show details]
…effects of glucocorticoids . Intraarticular injections of long-acting glucocorticoids (eg, triamcinolone hexacetonide) are used to reduce synovitis in particular joints that are more inflamed than others.…
4. 尋常性ざ瘡のための光治療、補助化学療法、およびその他の治療法light based adjunctive and other therapies for acne vulgaris [show details]
…Treated lesions typically flatten in 48 to 72 hours, improving appearance and discomfort . Triamcinolone acetonide, in concentrations of 1.25 to 2.5 mg/mL, is typically injected using a 30-gauge needle. There …
5. ケミカルピーリング：手技および合併症chemical peels procedures and complications [show details]
…established. Our approach consists of judicious use of a midpotency topical corticosteroid (triamcinolone acetonide 0.1% cream or ointment) for one or two days of each week. Patients for whom erythema causes …

English Journal

Intraarticular Injection of a Cross-Linked Sodium Hyaluronate Combined with Triamcinolone Hexacetonide (Cingal) to Provide Symptomatic Relief of Osteoarthritis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Trial.

Hangody L1, Szody R2, Lukasik P3, Zgadzaj W4, Lénárt E5, Dokoupilova E6, Bichovsk D7, Berta A1, Vasarhelyi G1, Ficzere A1, Hangody G1, Stevens G8, Szendroi M9.
Cartilage.Cartilage.2018 Jul;9(3):276-283. doi: 10.1177/1947603517703732. Epub 2017 May 23.
PMID 28535076

Simultaneous determination of triamcinolone hexacetonide and triamcinolone acetonide in rabbit plasma using a highly sensitive and selective UPLC-MS/MS method.

Sun W1, Ho S2, Fang XR2, O'Shea T2, Liu H3.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2018 May 10;153:267-273. doi: 10.1016/j.jpba.2018.02.052. Epub 2018 Feb 23.
PMID 29550043

Inflammatory arthritis or osteoarthritis of the knee - Efficacy of intra-joint infiltration of methylprednisolone acetate versus triamcinolone acetonide or triamcinolone hexacetonide.

Brazilian Medical Association, Silvinato A1, Bernardo WM1.
Revista da Associacao Medica Brasileira (1992).Rev Assoc Med Bras (1992).2017 Oct;63(10):827-836. doi: 10.1590/1806-9282.63.10.827.
PMID 29267483

Japanese Journal

A case of uremic pericarditis treated by thoracoscopic pericardiectomy.

青木雅信,中野優,吉原仁宣,大井諭,鈴木和雄,藤田公生
日本透析医学会雑誌 32(9), 1269-1273, 1999
… Although intensive dialysis combined with hemodiafiltration, pericardiocentesis and instillation of triamcinolone hexacetonide into the pericardiac cavity were performed, pericardial effusion did not decrease. …
NAID 130003721556

Reversal of intractable uremic pericarditis by triamcinolone hexacetonide.

FULLER T. J
Arch Intern Med 136, 979-982, 1976
NAID 30005417060

A comparison of intralesional triamcinolone hexacetonide and triamcinolone acetonide in alopecia areata

PORTER D
Br J Dermatol 85, 272-273, 1971
NAID 30014646249

Related Pictures

★リンクテーブル★

リンク元	「triamcinolone diacetate」「トリアムシノロンヘキサセトニド」「ARISTOSPAN」「KENALOG-40」
関連記事	「triamcinolone」

「triamcinolone diacetate」

Triamcinolone
Systematic (IUPAC) name
	(11β,16α)-9-fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Clinical data
Trade names	Kenalog
AHFS/Drugs.com	monograph
Pregnancy cat.	A (AU) C (US)
Legal status	POM (UK) ℞-only (US)
Routes	Oral, topical, IM, intra-articular, intrasynovial
Pharmacokinetic data
Protein binding	68%
Metabolism	Hepatic
Half-life	88 minutes
Excretion	Fecal and renal
Identifiers
CAS number	124-94-7
ATC code	A01AC01 C05AA12, D07AB09, H02AB08, R01AD11, R03BA06, S01BA05
PubChem	CID 31307
IUPHAR ligand	2870
DrugBank	DB00620
ChemSpider	29046
UNII	1ZK20VI6TY
KEGG	D00385
ChEMBL	CHEMBL1451
Synonyms	Click show to see (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; (1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
Chemical data
Formula	C21H27FO6
Mol. mass	394.434 g/mol
	SMILES O=C(CO)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)CC[C@H]4[C@@H]2C[C@H]3O)C)C;
	InChI InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1 ; Key:GFNANZIMVAIWHM-OBYCQNJPSA-N ;
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