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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/29 18:15:14」(JST)

Troleandomycin is a macrolide antibiotic. It is sold in Italy (branded Triocetin) and Turkey (branded Tekmisin).

Troleandomycin is a CYP3A4 inhibitor that may cause drug interactions.

This systemic antibacterial-related article is a stub. You can help Wikipedia by expanding it.

English Journal

Determination of time-dependent inactivation of CYP3A4 in cryopreserved human hepatocytes and assessment of human drug-drug interactions.

Chen Y, Liu L, Monshouwer M, Fretland AJ.SourceDepartment of Drug Metabolism and Pharmacokinetics, Roche-Palo Alto, LLC, California, USA.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2011 Nov;39(11):2085-92. Epub 2011 Aug 11.
Assessment of time-dependent inhibition (TDI), especially CYP3A4, is an important parameter for preclinical and clinical development. The use of human liver microsomes (HLM) is the most common in vitro matrix to assess TDI, but this often leads to an overprediction of an actual effect observed clini
PMID 21835977

In vitro metabolism of nobiletin, a polymethoxy-flavonoid, by human liver microsomes and cytochrome P450.

Koga N, Ohta C, Kato Y, Haraguchi K, Endo T, Ogawa K, Ohta H, Yano M.SourceFaculty of Nutritional Sciences, Nakamura Gakuen University, Johnan-ku, Fukuoka, Japan. nobuyuki@nakamura-u.ac.jp
Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2011 Nov;41(11):927-33. Epub 2011 Jul 5.
Cytochrome P450 enzymes (CYPs) in the liver metabolize drugs prior to excretion, with different enzymes acting at different molecular motifs. At present, the human CYPs responsible for the metabolism of the flavonoid, nobiletin (NBL), are unidentified. We investigated which enzymes were involved usi
PMID 21726170

Evaluation of triacetyloleandomycin, α-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochrome P450

Carbamazepine intoxication due to triacetyloleandomycin administration in epileptic patients

リンク元	「TAO」「トリアセチルオレアンドマイシン」「トロレアンドマイシン」

Troleandomycin
Systematic (IUPAC) name
	(3R,5R,6R,7S,8R,11R,12S,13R,14S,15S)-12-[(4-O-acetyl-2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)oxy]-14-{[2-O-acetyl-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-5,7,8,11,13,15-hexamethyl-4,10-dioxo-1,9-dioxaspiro[2.13]hexadec-6-yl acetate
Clinical data
AHFS/Drugs.com	Multum Consumer Information
MedlinePlus	a604026
Identifiers
CAS Number	2751-09-9
ATC code	J01FA08 (WHO)
PubChem	CID 5284630
DrugBank	DB01361
ChemSpider	4447675
UNII	C4DZ64560D
KEGG	D01322
ChEBI	CHEBI:45735
ChEMBL	CHEMBL564085
Chemical data
Formula	C41H67NO15
Molar mass	813.968 g/mol
	SMILES O=C(O[C@@H]4[C@@H](N(C)C)C[C@H](O[C@H]4O[C@@H]3[C@H]([C@H](O[C@@H]1O[C@H]([C@H](OC(=O)C)[C@@H](OC)C1)C)[C@H](C(=O)O[C@H](C)[C@H](C)[C@H](OC(=O)C)[C@H](C(=O)[C@]2(OC2)C[C@@H]3C)C)C)C)C)C ;
	InChI InChI=1S/C41H67NO15/c1-19-17-41(18-49-41)38(46)23(5)34(53-27(9)43)21(3)25(7)52-39(47)24(6)35(56-32-16-31(48-14)36(26(8)51-32)54-28(10)44)22(4)33(19)57-40-37(55-29(11)45)30(42(12)13)15-20(2)50-40/h19-26,30-37,40H,15-18H2,1-14H3/t19-,20+,21-,22+,23+,24+,25+,26-,30-,31-,32-,33-,34-,35-,36-,37+,40-,41-/m0/s1 ; Key:LQCLVBQBTUVCEQ-MCQAQMIOSA-N ;
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