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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/18 20:59:41」(JST)
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- 1. 経皮的冠動脈形成術後の再狭窄予防のための長期内科的治療が果たし得る役割 possible role of long term medical therapies to prevent restenosis following percutaneous coronary intervention
- 2. 経頸静脈的肝内門脈大循環短絡術の合併症 complications of transjugular intrahepatic portosystemic shunts
English Journal
- Trapidil, a platelet-derived growth factor antagonist, inhibits osteoclastogenesis by down-regulating NFATc1 and suppresses bone loss in mice.
- Kim SD, Kim HN, Lee JH, Jin WJ, Hwang SJ, Kim HH, Ha H, Lee ZH.SourceDepartment of Cell and Developmental Biology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul 110-749, Republic of Korea.
- Biochemical pharmacology.Biochem Pharmacol.2013 Sep 15;86(6):782-90. doi: 10.1016/j.bcp.2013.07.015. Epub 2013 Aug 6.
- Trapidil, a platelet-derived growth factor antagonist, was originally developed as a vasodilator and anti-platelet agent and has been used to treat patients with ischemic coronary heart, liver, and kidney disease. In this study, we investigated the effects of trapidil on osteoclastogenesis and eluci
- PMID 23928189
- Antithrombotic therapy for improving maternal or infant health outcomes in women considered at risk of placental dysfunction.
- Dodd JM, McLeod A, Windrim RC, Kingdom J.SourceSchool of Paediatrics and Reproductive Health, Discipline of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, Australia. jodie.dodd@adelaide.edu.au.
- The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2013 Jul 24;7:CD006780. doi: 10.1002/14651858.CD006780.pub3.
- BACKGROUND: Pregnancy complications such as pre-eclampsia and eclampsia, intrauterine growth restriction and placental abruption are thought to have a common origin related to abnormalities in the development and function of the placenta.OBJECTIVES: To compare, using the best available evidence, the
- PMID 23884904
- Aspirin intolerance and the need for dual antiplatelet therapy after stent implantation: a proposed alternative regimen.
- Latib A, Ielasi A, Ferri L, Chieffo A, Godino C, Carlino M, Montorfano M, Colombo A.SourceInterventional Cardiology Unit, San Raffaele Scientific Institute, Milan, Italy.
- International journal of cardiology.Int J Cardiol.2013 May 25;165(3):444-7. doi: 10.1016/j.ijcard.2011.08.080. Epub 2011 Oct 2.
- BACKGROUND: Dual antiplatelet therapy (DAT, i.e. aspirin+thienopyridine) has been shown to reduce the risk of stent thrombosis (ST) and myocardial infarction (MI) after coronary stent implantation. Data regarding alternative antiplatelet therapy in patients with allergy or intolerance to aspirin are
- PMID 21968077
Japanese Journal
- Ischemia-reperfusion injury of rabbit ovary and protective effect of trapidil : an experimental study
- SOMUNCU Salih,CAKMAK Murat,DIKMEN Gunnur,AKMAN Hulya,KAYA Murat
- Pediatric surgery international 24(3), 315-318, 2008-03-01
- NAID 10027861265
- Protective effects of trapidil in ischemia-reperfusion injury due to testicular torsion and detorsion : An experimental study
- SOMUNCU SALIH,CAKMAK MURAT,ERDOGAN SIBEL,CAGLAYAN OSMAN,AKMAN HULYA,KAYA MURAT
- International journal of urology 13(5), 601-605, 2006-05-01
- NAID 10019170812
Related Links
- Trapidil ist ein Arzneistoff, der in Form von Kapseln und Injektionen zur Behandlung der koronaren Herzkrankheit (KHK), zur Prophylaxe kardiovaskulärer Komplikationen nach einem Myokardinfarkt und in der Therapie der peripheren ...
- The latest from とらぴじる (@trapidil). とらちゃんだぉ、ROは休止中、PSO2 ９鯖で遊ん でます(´∀｀○） 最近はPSO2と仕事の休憩中にカルピス飲んでることくらいしか つぶやいてません(*´ω`)、. 岡山.
Related Pictures
★リンクテーブル★
| リンク元 | 「抗狭心症薬」「トラピジル」 |
「抗狭心症薬」
種類
硝酸薬
- 冠血管スパズム緩解→酸素供給↑
- 末梢血管拡張→心筋仕事量↓→心筋酸素需要↓
特徴
- 小動脈より静脈を拡張させる → 前負荷の減少
- 冠血管では、細い動脈より太い動脈を弛緩させる
β遮断薬
- 心筋抑制→心筋仕事量↓→心筋酸素需要↓
Ca拮抗薬
- 冠血管スパズム緩解→酸素供給↑ (SPC.226)
- 心筋抑制→心筋仕事量↓→心筋酸素需要↓
作用機序
- 電位依存性型Ca2+チャネルのαサブユニットに作用
その他の冠血管拡張薬
抗狭心症薬の使い分け
| 労作時狭心症 | 安静時狭心症 | 不安定狭心症 | |
| 硝酸薬 | ○ | ○ | ○ |
| β遮断薬 | ○ | ||
| Ca拮抗薬 | ○ |
「トラピジル」
- 冠血管拡張薬