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「an antidepressant drug that is a monoamine oxidase inhibitor; administered as a sulfate」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/14 14:34:59」(JST)

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  • An improved substrate cocktail for assessing direct inhibition and time-dependent inhibition of multiple cytochrome P450s.
  • Chen ZH1,2, Zhang SX3, Long N3, Lin LS3, Chen T3, Zhang FP3, Lv XQ3, Ye PZ3, Li N4, Zhang KZ3.
  • Acta pharmacologica Sinica.Acta Pharmacol Sin.2016 May;37(5):708-18. doi: 10.1038/aps.2016.10. Epub 2016 Apr 11.
  • AIM: The substrate cocktail is frequently used to evaluate cytochrome P450 (CYP) enzyme-mediated drug interactions and potential interactions among the probe substrates. Here, we re-optimized the substrate cocktail method to increase the reliability and accuracy of screening for candidate compounds
  • PMID 27063220
  • The histone demethylase LSD1 is a novel oncogene and therapeutic target in oral cancer.
  • Wang Y1, Zhu Y1, Wang Q1, Hu H1, Li Z2, Wang D3, Zhang W4, Qi B4, Ye J3, Wu H3, Jiang H3, Liu L5, Yang J2, Cheng J6.
  • Cancer letters.Cancer Lett.2016 Apr 28;374(1):12-21. doi: 10.1016/j.canlet.2016.02.004. Epub 2016 Feb 9.
  • The histone demethylase LSD1 functions as a key pro-oncogene and attractive therapeutic target in human cancer. Here we sought to interrogate the oncogenic roles of LSD1 in OSCC tumorigenesis and therapeutic intervention by integrating chemical-induced OSCC model, genetic and pharmacological loss-of
  • PMID 26872725
  • Inhibitors of LSD1 as a potential therapy for acute myeloid leukemia.
  • Przespolewski A1, Wang ES1.
  • Expert opinion on investigational drugs.Expert Opin Investig Drugs.2016 Apr 21:1-10. [Epub ahead of print]
  • INTRODUCTION: Epigenetic dysregulation plays a critical role in the pathogenesis of acute myeloid leukemia (AML). Alterations in histone methylation lead to aberrant silencing of expression of multiple genes involved in tumor suppression and cell cycling, resulting in myeloid maturation arrest and p
  • PMID 27077938



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