transporter protein

出典: meddic

translocatortransport proteintransporter

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/05 04:58:44」(JST)

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英文文献

  • First Steps Towards a Vaccine against Acinetobacter baumannii.
  • Garcia-Quintanilla M, Pulido MR, McConnell MJ1.Author information 1Unit of Infectious Disease, Microbiology, and Preventive Medicine, Hospital Universitario Virgen del Rocio/Instituto de Biomedicina de Sevilla, Avenida Manuel Siurot s/n, 41013 Sevilla, Spain. mcconnell.mike75@gmail.com.AbstractAcinetobacter baumannii has become an important cause of human infections, most notably in the hospital setting. In addition, the global dissemination of multidrug resistant strains has complicated effective antibiotic therapy of infections produced by this pathogen, necessitating the development of novel treatment and prevention strategies. Active and passive immunization approaches have begun to be explored in experimental animal models as potential alternative therapies for A. baumannii. In the present review, we discuss the advantages and disadvantages of each therapeutic strategy with respect to A. baumannii infections, and summarize the recent studies that have explored these approaches. The single antigen candidates that have been tested include, the outer membrane protein OmpA, the membrane transporter Ata, the biofilm-associated protein Bap, the K1 capsular polysaccharide and the membrane associated polysaccharide poly-N-acetyl-β -(1-6)-glucosamine. Strategies employing multicomponent antigens include inactivated whole cells, outer membrane complexes and outer membrane vesicles. The strengths and limitations of each approach are discussed and the challenges that remain to be addressed for successful A. baumannii vaccine development are highlighted.
  • Current pharmaceutical biotechnology.Curr Pharm Biotechnol.2014 Nov;14(10):897-902.
  • Acinetobacter baumannii has become an important cause of human infections, most notably in the hospital setting. In addition, the global dissemination of multidrug resistant strains has complicated effective antibiotic therapy of infections produced by this pathogen, necessitating the development of
  • PMID 24372252
  • Genome-based approaches to develop epitope-driven subunit vaccines against pathogens of infective endocarditis.
  • Priyadarshini V1, Pradhan D, Munikumar M, Swargam S, Umamaheswari A, Rajasekhar D.Author information 1a SVIMS Bioinformatics Centre, SVIMS University , Tirupati , Andhra Pradesh , 517507 , India .AbstractInfective endocarditis (IE) has emerged as a public health problem due to changes in the etiologic spectrum and due to involvement of resistant bacterial strains with increased virulence. Developing potent vaccine is an important strategy to tackle IE. Complete genome sequences of eight selected pathogens of IE paved the way to design common T-cell driven subunit vaccines. Comparative genomics and subtractive genomic analysis were applied to identify adinosine tri phosphate (ATP)-binding cassette (ABC) transporter ATP-binding protein from Streptococcus mitis (reference organism) as common vaccine target. Reverse vaccinology technique was implemented using computational tools such as ProPred, SYFPEITHI, and Immune epitope database. Twenty-one T-cell epitopes were predicted from ABC transporter ATP-binding protein. Multiple sequence alignment of ABC transporter ATP-binding protein from eight selected IE pathogens was performed to identify six conserved T-cell epitopes. The six selected T-cell epitopes were further evaluated at structure level for HLA-DRB binding through homology modeling and molecular docking analysis using Maestro v9.2. The proposed six T-cell epitopes showed better binding affinity with the selected HLA-DRB alleles. Subsequently, the docking complexes of T-cell epitope and HLA-DRBs were ranked based on XP Gscore. The T-cell epitope (208-LNYITPDVV-216)-HLA-DRB1(∗)0101 (1T5 W) complex having the best XP Gscore (-13.25 kcal/mol) was assessed for conformational stability and interaction stability through molecular dynamic simulation for 10 ns using Desmond v3.2. The simulation results revealed that the HLA-DRB-epitope complex was stable throughout the simulation time. Thus, the epitope would be ideal candidate for T-cell driven subunit vaccine design against infective endocarditis.
  • Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2014 Jun;32(6):876-89. doi: 10.1080/07391102.2013.795871. Epub 2013 Jun 19.
  • Infective endocarditis (IE) has emerged as a public health problem due to changes in the etiologic spectrum and due to involvement of resistant bacterial strains with increased virulence. Developing potent vaccine is an important strategy to tackle IE. Complete genome sequences of eight selected pat
  • PMID 24404767
  • Expression of tapasin in rainbow trout tissues and cell lines and up regulation in a monocyte/macrophage cell line (RTS11) by a viral mimic and viral infection.
  • Sever L1, Vo NT1, Bols NC1, Dixon B2.Author information 1Department of Biology, University of Waterloo, 200 University Ave W., Waterloo, Ontario N2L 3G1, Canada.2Department of Biology, University of Waterloo, 200 University Ave W., Waterloo, Ontario N2L 3G1, Canada. Electronic address: bdixon@uwaterloo.ca.AbstractTapasin is a transmembrane glycoprotein that acts as a bridge between the transporter associated with antigen processing and the MHC class I receptor in mammals. Through the development of antibody against trout tapasin, this report demonstrates the detection of trout tapasin as a N-glycosylated 48kDa protein. Tissue and cell line distribution revealed that tapasin protein is expressed mainly in immune system organs and in rainbow trout epithelial cell lines from gill (RTgill-W1), liver (RTL-W1), and intestine (RTgutGC). An additional 20kDa band was observed in tissues and cell lines, and appeared to be most prominent in RTgutGC but was absent in peripheral blood leukocytes. Tapasin 48kDa protein was most strongly expressed in RTS11 (monocyte/macrophage cell line) and its regulation following dsRNA stimulation was explored. Upon poly I:C treatment and Chum Salmon Reovirus (CSV) infection, tapasin protein expression was upregulated up to 3.5 fold and 3 fold respectively, in parallel with increased expression of the glycosylated MH class I heavy chain, whereas the expression of the 20kDa form remained unchanged. Overall this work demonstrates the induction of tapasin protein by dsRNA stimulation, which implies its possible conserved regulation during viral infection in teleost cells.
  • Developmental and comparative immunology.Dev Comp Immunol.2014 May;44(1):86-93. doi: 10.1016/j.dci.2013.11.019. Epub 2013 Dec 7.
  • Tapasin is a transmembrane glycoprotein that acts as a bridge between the transporter associated with antigen processing and the MHC class I receptor in mammals. Through the development of antibody against trout tapasin, this report demonstrates the detection of trout tapasin as a N-glycosylated 48k
  • PMID 24321527

和文文献

  • Lipopolysaccharide-induced serotonin transporter up-regulation involves PKG-I and p38MAPK activation partially through A3 adenosine receptor
  • Identification of sheep red blood cell (SRBC) surface immune-responsive peptides detected by antisera from SRBC-immunized rats
  • Structural Basis for Heme Recognition by HmuT Responsible for Heme Transport to the Heme Transporter in Corynebacterium glutamicum

関連リンク

A novel protein which has an activity to transport hydantoin compounds is described, as well as a recombinant expressing this transporter protein. From Microbacterium liquefaciens strain AJ3912 ... EP1188826 2002-03 ...
TransportDB is a relational database describing the predicted cytoplasmic membrane transport protein complement for organisms whose complete genome sequence are available. For each organism, its complete membrane transport ...

関連画像

model of the YiiP zinc transporter protein transport proteinsNew membrane protein structure reveals Transport Proteins.Transporter protein involved in renal The transporter protein is a


★リンクテーブル★
先読みトランスポーター」「輸送体
リンク元transport protein」「輸送体タンパク質」「トランスポータータンパク質」「translocator
拡張検索sodium-phosphate cotransporter protein」「type IIa sodium-phosphate cotransporter protein」「type II sodium-phosphate cotransporter protein」「type I sodium-phosphate cotransporter protein
関連記事transport」「transporter」「protein」「transporters

トランスポーター」

  [★]

transporter
運搬体輸送体
  • (ECB.395)
  • トランスポーターによる能動輸送形式
  • 共役輸送体
  • シンポート
  • アンチポート
  • ATP駆動ポンプ
  • 光駆動ポンプ


輸送体」

  [★] トランスポーター


transport protein」

  [★]

binding proteincarrier proteintranslocatortransportertransporter protein


輸送体タンパク質」

  [★]

transporter protein
トランスポーター輸送体輸送タンパク質トランスポータータンパク質


トランスポータータンパク質」

  [★]

transporter protein
トランスポーター輸送体輸送タンパク質輸送体タンパク質


translocator」

  [★]

transport proteintransportertransporter protein


sodium-phosphate cotransporter protein」

  [★]

ナトリウム・リン酸共輸送体

sodium-phosphate cotransporter


type IIa sodium-phosphate cotransporter protein」

  [★]

IIa型ナトリウム・リン酸共輸送体


type II sodium-phosphate cotransporter protein」

  [★]

II型ナトリウム・リン酸共輸送体


type I sodium-phosphate cotransporter protein」

  [★]

I型ナトリウム・リン酸共輸送体


transport」

  [★]

  • n.
  • v.
  • 輸送する、運搬する、運ぶ
bringcarriagecarryconveydeliveryshiptraffictraffickingtransportation

WordNet   license wordnet

「move something or somebody around; usually over long distances」

WordNet   license wordnet

「an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes」

PrepTutorEJDIC   license prepejdic

「(ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機」

WordNet   license wordnet

「move while supporting, either in a vehicle or in one''s hands or on one''s body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river"」
carry

WordNet   license wordnet

「transport commercially」
send, ship


transporter」

  [★] トランスポーター

translocatortransport proteintransporter protein

PrepTutorEJDIC   license prepejdic

「自動車運搬用大型トラック」

WordNet   license wordnet

「a long truck for carrying motor vehicles」
car transporter

WordNet   license wordnet

「a crane for moving material with dispatch as in loading and unloading ships」


protein」

  [★] 蛋白質

WordNet   license wordnet

「any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"」

PrepTutorEJDIC   license prepejdic

「蛋白(たんばく)質」


transporters」

  [★] トランスポーター




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