同: TAP2

WordNet

having partial rights and privileges or subordinate status; "an associate member"; "an associate professor"
a person who joins with others in some activity or endeavor; "he had to consult his associate before continuing"
a person with subordinate membership in a society, institution, or commercial enterprise; "associates in the law firm bill at a lower rate than do partners"
any event that usually accompanies or is closely connected with another; "first was the lightning and then its thunderous associate"
make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all" (同)tie_in, relate, link, colligate, link up, connect
a show or display; the act of presenting something to sight or view; "the presentation of new data"; "he gave the customer a demonstration" (同)presentment, demonstration
(obstetrics) position of the fetus in the uterus relative to the birth canal; "Cesarean sections are sometimes the result of abnormal presentations"
the activity of formally presenting something (as a prize or reward); "she gave the trophy but he made the presentation"
formally making a person known to another or to the public (同)introduction, intro
the act of making something publicly available; presenting news or other information by broadcasting or printing it; "he prepared his presentation carefully in advance"
the act of presenting a proposal
move something or somebody around; usually over long distances
an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
transport commercially (同)send, ship
a message whose ingenuity or verbal skill or incongruity has the power to evoke laughter (同)humor, humour, witticism, wittiness

PrepTutorEJDIC

〈人〉'を'(…の)『仲間に加える』,(…に)連合させる《+『名』〈人〉+『with』+『名』》 / (…と)…'を'結びつけて考える(起こす)《+『名』+『with』+『名』》 / (…と)『仲間になる』,交際する《+『with』+『名』》 / (…と)合体する,提携する《+『with』+『名』》 / 『仲間』,『同僚』;組合員 / 準会員 / 付属物;連想されるもの / 連合した;仲間の,同僚の / 補助の,準…
〈U〉〈C〉(…の)贈呈,贈与《+『of』+『名』》 / 〈U〉〈C〉◇公式の)紹介,披露(ひろう);(劇・影画などの)上演 / (一般に)発表;提出,提示
(ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
《随伴・協調》…『と』,と共に,といっしょに / 《所有・所持》…『を持っている』,がある,の付いた / 《道具・手段》…『で』,を使って / 《財料・供給物》…『で』,を与えて / …を支持して,に賛成して / …『に反対(敵対)して』,を相手として / …『と同時に』,と同様に / …『に比べて』,に比例して / 《様態》《名詞を伴い副詞句として》『…で』,を示して,をもって / 《付帯状競》…『して』,しながら / 《譲歩》…がありながら,にもかかわらず / 『…が原因で』,のために,…で / …に任せて,のもとにあずけて,のところに / …に関して,について / …から離れて / 《連結・混合》…と / 《副詞と共に命令文で》
知る(know)
〈U〉『機知』,機転,ウィット / 〈C〉『機知に富む人』,機転のきく人 / 《複数形で;単数扱い》『理解(表現)力』,知性 / 《複数形で》(物事を見抜いたりもくろんだりする)才覚,才知 / 《複数形で;単数扱い》正気

UpToDate Contents

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1. Antigen-presenting cells
2. 1型糖尿病の病因 pathogenesis of type 1 diabetes mellitus
3. 移植免疫 transplantation immunobiology
4. 前立腺癌の臨床所見および診断 clinical presentation and diagnosis of prostate cancer
5. 人工呼吸器関連肺炎の臨床症状および診断 clinical presentation and diagnosis of ventilator associated pneumonia

English Journal

β2-Microglobulin deficiency causes a complex immunodeficiency of the innate and adaptive immune system.

Ardeniz Ö1, Unger S2, Onay H3, Ammann S2, Keck C4, Cianga C5, Gerçeker B6, Martin B7, Fuchs I2, Salzer U2, İkincioğulları A8, Güloğlu D8, Dereli T6, Thimme R7, Ehl S2, Schwarz K9, Schmitt-Graeff A4, Cianga P5, Fisch P4, Warnatz K2.
The Journal of allergy and clinical immunology.J Allergy Clin Immunol.2015 Feb 19. pii: S0091-6749(15)00019-6. doi: 10.1016/j.jaci.2014.12.1937. [Epub ahead of print]
BACKGROUND: Most patients with MHC class I (MHC-I) deficiency carry genetic defects in transporter associated with antigen processing 1 (TAP1) or TAP2. The clinical presentation can vary, and about half of the patients have severe skin disease. Previously, one report described β2-microglobulin (β2
PMID 25702838

Ultrasensitive quantification of TAP-dependent antigen compartmentalization in scarce primary immune cell subsets.

Fischbach H1, Döring M2, Nikles D1, Lehnert E1, Baldauf C1, Kalinke U2, Tampé R3.
Nature communications.Nat Commun.2015 Feb 6;6:6199. doi: 10.1038/ncomms7199.
Presentation of peptides on major histocompatibility complex class I (MHC I) is essential for the establishment and maintenance of self-tolerance, priming of antigen-specific CD8(+) T cells and the exertion of several T-cell effector functions. Cytosolic proteasomes continuously degrade proteins int
PMID 25656091

Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter.

Grossmann N1, Vakkasoglu AS2, Hulpke S1, Abele R1, Gaudet R2, Tampé R3.
Nature communications.Nat Commun.2014 Nov 7;5:5419. doi: 10.1038/ncomms6419.
The ATP-binding cassette (ABC) transporter associated with antigen processing (TAP) participates in immune surveillance by moving proteasomal products into the endoplasmic reticulum (ER) lumen for major histocompatibility complex class I loading and cell surface presentation to cytotoxic T cells. He
PMID 25377891

Japanese Journal

クロスプレゼンテーションとストレス応答蛋白Hsp

山﨑千尋,鵜殿平一郎
臨床免疫・アレルギー科 62(1), 105-110, 2014-07
NAID 40020155559

Cytosolic Processing of Proteasomal Cleavage Products Can Enhance the Presentation Efficiency of MHC-1 Epitopes

Bulik Sascha,Peters Björn,Ebeling Christian,Holzhütter Hergo
Ｇｅｎｏｍｅ　Ｉｎｆｏｒｍａｔｉｃｓ 15(1), 24-34, 2004
… The generation of an epitope starts with the degradation of endogenous proteins into primary oligomeric fragments by cytosolic proteases, predominantly the proteasome. … These primary fragments may be further attacked by various amino peptidases resident in the cytosol or, alternatively, may escape from this attack by entering the endoplasmic reticulum (ER) by the transporter associated with antigen presentation (TAP). …
NAID 130003812078