WordNet

communicate with and within a group; "You have to network if you want to get a good job"
(electronics) a system of interconnected electronic components or circuits (同)electronic network
(broadcasting) a communication system consisting of a group of broadcasting stations that all transmit the same programs; "the networks compete to broadcast important sports events"
a system of intersecting lines or channels; "a railroad network"; "a network of canals"
an interconnected system of things or people; "he owned a network of shops"; "retirement meant dropping out of a whole network of people who had been part of my life"; "tangled in a web of cloth" (同)web

PrepTutorEJDIC

〈U〉〈C〉網,網細工 / 〈C〉『網状のもの』 / 〈C〉(ラジオ・テレビの)放送網
移植;移植した物 / 移住 / (内臓などの)移植術

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1. 心臓移植の適応および禁忌 indications and contraindications for cardiac transplantation
2. 腎移植におけるHLAとABOの感作および脱感作 hla and abo sensitization and desensitization in renal transplantation
3. 生体肝移植 living donor liver transplantation
4. 腎移植における非血縁生体ドナー living unrelated donors in renal transplantation
5. 肝細胞癌に対する肝移植 liver transplantation for hepatocellular carcinoma

English Journal

GATA-2 inhibits transforming growth factor-β signaling pathway through interaction with Smad4.

Dong XM1, Yin RH2, Yang Y3, Feng ZW2, Ning HM4, Dong L5, Zheng WW2, Tang LJ2, Wang J2, Jia YX6, Jiang YN7, Liu ED7, Chen H2, Zhan YQ2, Yu M2, Ge CH2, Li CY8, Yang XM9.Author information 1School of Chemical Engineering and Technology, Department of Pharmaceutical Engineering, Tianjin University, Tianjin 300072, China; State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.2State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.3Purdue University, Department of Biological Sciences, 915W. State Street, West Lafayette, IN 47907-2054, United States.4Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital to Academy of Military Medical Sciences, Beijing 100071, China.5Department of Anesthesiology, General Hospital of Chinese People's Armed Police Forces, Beijing, China.6School of Chemical Engineering and Technology, Department of Pharmaceutical Engineering, Tianjin University, Tianjin 300072, China.7An Hui Medical University, Hefei 230032, China.8State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China; An Hui Medical University, Hefei 230032, China. Electronic address: fmmli@163.com.9School of Chemical Engineering and Technology, Department of Pharmaceutical Engineering, Tianjin University, Tianjin 300072, China; State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address: xiaomingyang@sina.com.AbstractGATA-2, a member of zinc finger GATA transcription factor family, plays key role in the hematopoietic stem cells self-renewal and differentiation. The transforming growth factor-β (TGFβ) signaling pathway is a major signaling network that controls cell proliferation, differentiation and tumor suppression. Here we found that GATA-2 negatively regulated TGF-β signaling pathway in Smad4-dependent manner. GATA-2 specifically interacts with Smad4 with its N-terminal while the zinc finger domain of GATA-2 is essential for negative regulation of TGFβ. Although GATA-2 did not affect the phosphorylation of Smad2/3 and the complex Smad2/3/4 formation in response to TGFβ, the DNA binding activity of Smad4 was decreased significantly by GATA-2 overexpression. Overexpression of GATA-2 in K562 cells led to reduced TGFβ-induced erythroid differentiation while knockdown of GATA-2 enhanced TGFβ-induced erythroid differentiation. All these results suggest that GATA-2 is a novel negative regulator of TGFβ signal pathway.
Cellular signalling.Cell Signal.2014 May;26(5):1089-97. doi: 10.1016/j.cellsig.2014.01.028. Epub 2014 Feb 5.
GATA-2, a member of zinc finger GATA transcription factor family, plays key role in the hematopoietic stem cells self-renewal and differentiation. The transforming growth factor-β (TGFβ) signaling pathway is a major signaling network that controls cell proliferation, differentiation and tumor supp
PMID 24509415

Glutathione s-transferase iso-enzymes in perfusate from pumped kidneys are associated with delayed graft function.

Hall IE1, Bhangoo RS, Reese PP, Doshi MD, Weng FL, Hong K, Lin H, Han G, Hasz RD, Goldstein MJ, Schröppel B, Parikh CR.Author information 1Program of Applied Translational Research, Department of Medicine, Yale University School of Medicine, New Haven, CT; Section of Nephrology, Yale University School of Medicine, New Haven, CT.AbstractAccurate and reliable assessment tools are needed in transplantation. The objective of this prospective, multi-center study was to determine the associations of the alpha and pi iso-enzymes of glutathione S-transferase (GST), measured from perfusate solution at the start and end (base and post) of kidney allograft machine perfusion, with subsequent delayed graft function (DGF). We also compared GST iso-enzyme perfusate levels from discarded versus transplanted kidneys. A total of 428 kidneys were linked to outcomes as recorded by the United Network of Organ Sharing. DGF, defined as any dialysis in the first week of transplant, occurred in 141 recipients (32%). Alpha- and pi-GST levels significantly increased during machine perfusion. The adjusted relative risks (95% confidence interval) of DGF with each log-unit increase in base and post pi-GST were 1.14 (1.0-1.3) and 1.36 (1.1-1.8), respectively. Alpha-GST was not independently associated with DGF. There were no significant differences in GST values between discarded and transplanted kidneys, though renal resistance was significantly higher in discarded kidneys. We found pi-GST at the end of machine perfusion to be independently associated with DGF. Further studies should elucidate the utility of GST for identifying injured kidneys with regard to organ allocation, discard and recipient management decisions.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.Am J Transplant.2014 Apr;14(4):886-96. doi: 10.1111/ajt.12635. Epub 2014 Feb 24.
Accurate and reliable assessment tools are needed in transplantation. The objective of this prospective, multi-center study was to determine the associations of the alpha and pi iso-enzymes of glutathione S-transferase (GST), measured from perfusate solution at the start and end (base and post) of k
PMID 24612768

Economic consequences incurred by living kidney donors: a canadian multi-center prospective study.

Klarenbach S1, Gill JS, Knoll G, Caulfield T, Boudville N, Prasad GV, Karpinski M, Storsley L, Treleaven D, Arnold J, Cuerden M, Jacobs P, Garg AX; Donor Nephrectomy Outcomes Research (DONOR) Network.Author information 1Department of Medicine, Institute of Health Economics, Edmonton, AB, Canada.AbstractSome living kidney donors incur economic consequences as a result of donation; however, these costs are poorly quantified. We developed a framework to comprehensively assess economic consequences from the donor perspective including out-of-pocket cost, lost wages and home productivity loss. We prospectively enrolled 100 living kidney donors from seven Canadian centers between 2004 and 2008 and collected and valued economic consequences ($CAD 2008) at 3 months and 1 year after donation. Almost all (96%) donors experienced economic consequences, with 94% reporting travel costs and 47% reporting lost pay. The average and median costs of lost pay were $2144 (SD 4167) and $0 (25th-75th percentile 0, 2794), respectively. For other expenses (travel, accommodation, medication and medical), mean and median costs were $1780 (SD 2504) and $821 (25th-75th percentile 242, 2271), respectively. From the donor perspective, mean cost was $3268 (SD 4704); one-third of donors incurred cost >$3000, and 15% >$8000. The majority of donors (83%) reported inability to perform usual household activities for an average duration of 33 days; 8% reported out-of-pocket costs for assistance with these activities. The economic impact of living kidney donation for some individuals is large. We advocate for programs to reimburse living donors for their legitimate costs.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.Am J Transplant.2014 Apr;14(4):916-22. doi: 10.1111/ajt.12662. Epub 2014 Mar 5.
Some living kidney donors incur economic consequences as a result of donation; however, these costs are poorly quantified. We developed a framework to comprehensively assess economic consequences from the donor perspective including out-of-pocket cost, lost wages and home productivity loss. We prosp
PMID 24597854

Japanese Journal

脳梗塞後の機能回復 : 脳梗塞モデルとリハビリテーション(再生医療の進歩,2012年,第53回日本心身医学会総会ならびに学術講演会(鹿児島))

池田聡
心身医学 53(8), 742-747, 2013-08-01
脳はかつて変化しない臓器と考えられており,脳梗塞などにより障害された際いったん喪失した機能は改善しないと思われていた.しかし,脳は変化しうる能力"可塑性"をもっており,目を見張るものがあることがわかってきた.脳の神経細胞は外界からの刺激に対し随時変化適応していく能力があり,発達,学習など生理的なものだけでなく脳卒中など脳の障害や末梢神経障害,網膜損傷など感覚受容器の障害に照応し,脳の機能局在やネッ …
NAID 110009624738

造血細胞移植一元管理登録と登録研究

熱田由子
Journal of Hematopoietic Cell Transplantation
日本造血細胞移植学会（JSHCT），日本小児血液・がん学会（JSPHO），骨髄移植推進財団（JMDP），日本さい帯血バンクネットワーク（JCBBN）が古くは1980年代から収集してきた造血幹細胞移植アウトカム情報は，JSHCTが中心となり行った登録の一元化・電子化を経て一つの登録データベース（TRUMP）となった。最新データベースには65,000件を超える移植情報が蓄えられている。このデータベース …
NAID 130003379439

Under-Utilization of Donor Hearts in the Initial Era of the Heart Transplant Program in Korea:– Review of 13 Years' Experience From the Korea National Registry –

Cha Myung-Jin,Lee Hae-Young,Cho Hyun-Jai,Hwang Ho Young,Kim Ki-Bong,Oh Byung-Hee
Circulation Journal, 2013
… Background: Heart transplantation (HTPL) is the effective treatment option to improve quality of life as well as survival of terminal heart failure patients. … Methods and Results: Among 2,001 brain-death donors registered in Korean Network for Organ Sharing from February 2000 to May 2012, a total of 28% of hearts (n=552) were utilized for HTPL. …
NAID 130003361781