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English Journal

Avr4 promotes Cf-4 receptor-like protein association with the BAK1/SERK3 receptor-like kinase to initiate receptor endocytosis and plant immunity.

Postma J1, Liebrand TW2, Bi G2, Evrard A1, Bye RR2, Mbengue M1, Kuhn H1,3, Joosten MH2, Robatzek S1.
The New phytologist.New Phytol.2016 Apr;210(2):627-42. doi: 10.1111/nph.13802. Epub 2016 Jan 14.
The first layer of plant immunity is activated by cell surface receptor-like kinases (RLKs) and proteins (RLPs) that detect infectious pathogens. Constitutive interaction with the SUPPRESSOR OF BIR1 (SOBIR1) RLK contributes to RLP stability and kinase activity. As RLK activation requires transphosph
PMID 26765243

Isotope effect analyses provide evidence for an altered transition state for RNA 2'-O-transphosphorylation catalyzed by Zn(2.).

Zhang S1, Gu H1, Chen H2, Strong E1, Ollie EW1, Kellerman D1, Liang D1, Miyagi M3, Anderson VE1, Piccirilli JA4, York DM2, Harris ME1.
Chemical communications (Cambridge, England).Chem Commun (Camb).2016 Mar 15;52(24):4462-5. doi: 10.1039/c5cc10212j.
Solvent D2O and (18)O kinetic isotope effects on RNA 2'-O-transphosphorylation catalyzed by Zn(2+) demonstrate an altered transition state relative to specific base catalysis. A recent model from DFT calculations involving inner sphere coordination to the non-bridging and leaving group oxygens is co
PMID 26859380

A Bis(guanidinium)alcohol Attached to a Hairpin Polyamide: Synthesis, DNA Binding, and Plasmid Cleavage.

Wirth-Hamdoune D1, Ullrich S1, Scheffer U1, Radanović T1, Dürner G1, Göbel MW2.
Chembiochem : a European journal of chemical biology.Chembiochem.2016 Mar 15;17(6):506-14. doi: 10.1002/cbic.201500566. Epub 2016 Feb 16.
Bis(guanidinium)alcohols have been designed to react with phosphodiester substrates in a fast transphosphorylation step, a quasi-intramolecular process taking place in contact ion pairs. Here the attachment of such compounds to Dervan-type hairpin polyamides is described. The resulting conjugate 1
PMID 26749155

Matsuda Tadashi,Feng Jian,Witthuhn Bruce A.,Sekine Yuichi,Ihle James N.
Biochemical and Biophysical Research Communications 325(2), 586-594, 2004-12-10
… Activation of the signal begins with the transphosphorylation of Jak kinases. … In this study, baculovirus-produced Jak2 was utilized to demonstrate that transphosphorylation of Jak kinases occurs on multiple residues throughout the protein. …
NAID 120000972005