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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/17 17:30:44」(JST)
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| Transglutaminase 1 |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
|
2XZZ
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| Identifiers |
| Symbols |
TGM1 ; ARCI1; ICR2; KTG; LI; LI1; TGASE; TGK |
| External IDs |
OMIM: 190195 MGI: 98730 HomoloGene: 306 ChEMBL: 2810 GeneCards: TGM1 Gene |
| EC number |
2.3.2.13 |
| Gene ontology |
| Molecular function |
• protein-glutamine gamma-glutamyltransferase activity
• protein binding
• metal ion binding
|
| Cellular component |
• cornified envelope
• cell-cell adherens junction
• intrinsic component of membrane
• extracellular vesicular exosome
|
| Biological process |
• cellular protein modification process
• organ morphogenesis
• peptide cross-linking
• keratinocyte differentiation
• keratinization
• cell envelope organization
|
| Sources: Amigo / QuickGO |
|
| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
|
| Entrez |
7051 |
21816 |
|
| Ensembl |
ENSG00000092295 |
ENSMUSG00000022218 |
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| UniProt |
P22735 |
Q9JLF6 |
|
| RefSeq (mRNA) |
NM_000359 |
NM_001161714 |
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| RefSeq (protein) |
NP_000350 |
NP_001155186 |
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| Location (UCSC) |
Chr 14:
24.72 – 24.73 Mb |
Chr 14:
55.7 – 55.71 Mb |
|
| PubMed search |
[1] |
[2] |
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Protein-glutamine gamma-glutamyltransferase K is an enzyme that in humans is encoded by the TGM1 gene.[1][2]
Keratinocyte transglutaminase is a transglutaminase enzyme.
Contents
- 1 Pathology
- 2 See also
- 3 References
- 4 Further reading
- 5 External links
Pathology
A deficiency is associated with ichthyosis lamellaris.[3] Epidermal transglutaminase is the autoantigen, in humans, of dermatitis herpetiformis.
See also
References
- ^ Grenard P, Bates MK, Aeschlimann D (Aug 2001). "Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z". J Biol Chem 276 (35): 33066–78. doi:10.1074/jbc.M102553200. PMID 11390390.
- ^ "Entrez Gene: TGM1 transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)".
- ^ Hennies HC, Küster W, Wiebe V, Krebsová A, Reis A (1998). "Genotype/phenotype correlation in autosomal recessive lamellar ichthyosis". Am. J. Hum. Genet. 62 (5): 1052–61. doi:10.1086/301818. PMC 1377076. PMID 9545389.
Further reading
- Phillips MA, Stewart BE, Rice RH (1992). "Genomic structure of keratinocyte transglutaminase. Recruitment of new exon for modified function.". J. Biol. Chem. 267 (4): 2282–6. PMID 1346394.
- Kim IG, McBride OW, Wang M, et al. (1992). "Structure and organization of the human transglutaminase 1 gene.". J. Biol. Chem. 267 (11): 7710–7. PMID 1348508.
- Polakowska RR, Eickbush T, Falciano V, et al. (1992). "Organization and evolution of the human epidermal keratinocyte transglutaminase I gene.". Proc. Natl. Acad. Sci. U.S.A. 89 (10): 4476–80. doi:10.1073/pnas.89.10.4476. PMC 49105. PMID 1350092.
- Schroeder WT, Thacher SM, Stewart-Galetka S, et al. (1992). "Type I keratinocyte transglutaminase: expression in human skin and psoriasis.". J. Invest. Dermatol. 99 (1): 27–34. doi:10.1111/1523-1747.ep12611394. PMID 1351505.
- Yamanishi K, Inazawa J, Liew FM, et al. (1992). "Structure of the gene for human transglutaminase 1.". J. Biol. Chem. 267 (25): 17858–63. PMID 1381356.
- Kim HC, Idler WW, Kim IG, et al. (1991). "The complete amino acid sequence of the human transglutaminase K enzyme deduced from the nucleic acid sequences of cDNA clones.". J. Biol. Chem. 266 (1): 536–9. PMID 1670769.
- Yamanishi K, Liew FM, Konishi K, et al. (1991). "Molecular cloning of human epidermal transglutaminase cDNA from keratinocytes in culture.". Biochem. Biophys. Res. Commun. 175 (3): 906–13. doi:10.1016/0006-291X(91)91651-R. PMID 1673840.
- Polakowska R, Herting E, Goldsmith LA (1991). "Isolation of cDNA for human epidermal type I transglutaminase.". J. Invest. Dermatol. 96 (2): 285–8. doi:10.1111/1523-1747.ep12464554. PMID 1704039.
- Phillips MA, Stewart BE, Qin Q, et al. (1991). "Primary structure of keratinocyte transglutaminase.". Proc. Natl. Acad. Sci. U.S.A. 87 (23): 9333–7. doi:10.1073/pnas.87.23.9333. PMC 55159. PMID 1979171.
- Candi E, Melino G, Mei G, et al. (1995). "Biochemical, structural, and transglutaminase substrate properties of human loricrin, the major epidermal cornified cell envelope protein.". J. Biol. Chem. 270 (44): 26382–90. doi:10.1074/jbc.270.44.26382. PMID 7592852.
- Mariniello L, Esposito C, Di Pierro P, et al. (1993). "Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro.". Eur. J. Biochem. 215 (1): 99–104. doi:10.1111/j.1432-1033.1993.tb18011.x. PMID 7688299.
- Russell LJ, DiGiovanna JJ, Rogers GR, et al. (1995). "Mutations in the gene for transglutaminase 1 in autosomal recessive lamellar ichthyosis.". Nat. Genet. 9 (3): 279–83. doi:10.1038/ng0395-279. PMID 7773290.
- Huber M, Rettler I, Bernasconi K, et al. (1995). "Mutations of keratinocyte transglutaminase in lamellar ichthyosis.". Science 267 (5197): 525–8. doi:10.1126/science.7824952. PMID 7824952.
- Amendola A, Lombardi G, Oliverio S, et al. (1994). "HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A.". FEBS Lett. 339 (3): 258–64. doi:10.1016/0014-5793(94)80427-3. PMID 7906657.
- Kim SY, Kim IG, Chung SI, Steinert PM (1994). "The structure of the transglutaminase 1 enzyme. Deletion cloning reveals domains that regulate its specific activity and substrate specificity.". J. Biol. Chem. 269 (45): 27979–86. PMID 7961731.
- Steinert PM, Kim SY, Chung SI, Marekov LN (1996). "The transglutaminase 1 enzyme is variably acylated by myristate and palmitate during differentiation in epidermal keratinocytes.". J. Biol. Chem. 271 (42): 26242–50. doi:10.1074/jbc.271.39.24105. PMID 8824274.
- Laiho E, Ignatius J, Mikkola H, et al. (1997). "Transglutaminase 1 mutations in autosomal recessive congenital ichthyosis: private and recurrent mutations in an isolated population.". Am. J. Hum. Genet. 61 (3): 529–38. doi:10.1086/515498. PMC 1715945. PMID 9326318.
- Tarcsa E, Marekov LN, Andreoli J, et al. (1997). "The fate of trichohyalin. Sequential post-translational modifications by peptidyl-arginine deiminase and transglutaminases.". J. Biol. Chem. 272 (44): 27893–901. doi:10.1074/jbc.272.44.27893. PMID 9346937.
- Petit E, Huber M, Rochat A, et al. (1998). "Three novel point mutations in the keratinocyte transglutaminase (TGK) gene in lamellar ichthyosis: significance for mutant transcript level, TGK immunodetection and activity.". Eur. J. Hum. Genet. 5 (4): 218–28. PMID 9359043.
- Iwasaki W, Nagata K, Hatanaka H, et al. (1998). "Solution structure of midkine, a new heparin-binding growth factor.". EMBO J. 16 (23): 6936–46. doi:10.1093/emboj/16.23.6936. PMC 1170297. PMID 9384573.
External links
- TGM1 protein at the US National Library of Medicine Medical Subject Headings (MeSH)
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Transferases: acyltransferases (EC 2.3)
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| 2.3.1: other than amino-acyl groups |
- acetyltransferases: Acetyl-Coenzyme A acetyltransferase
- N-Acetylglutamate synthase
- Choline acetyltransferase
- Dihydrolipoyl transacetylase
- Acetyl-CoA C-acyltransferase
- Beta-galactoside transacetylase
- Chloramphenicol acetyltransferase
- N-acetyltransferase
- Serotonin N-acetyl transferase
- HGSNAT
- ARD1A
- Histone acetyltransferase
- palmitoyltransferases: Carnitine O-palmitoyltransferase
- Serine C-palmitoyltransferase
- other: Acyltransferase like 2
- Aminolevulinic acid synthase
- Beta-ketoacyl-ACP synthase
- Glyceronephosphate O-acyltransferase
- Lecithin-cholesterol acyltransferase
- Glycerol-3-phosphate O-acyltransferase
- 1-acylglycerol-3-phosphate O-acyltransferase
- 2-acylglycerol-3-phosphate O-acyltransferase
- ABHD5
|
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| 2.3.2: Aminoacyltransferases |
- Gamma-glutamyl transpeptidase
- Peptidyl transferase
- Transglutaminase
- Tissue transglutaminase
- Keratinocyte transglutaminase
- Factor XIII
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|
| 2.3.3: converted into alkyl on transfer |
- Citrate synthase
- ATP citrate lyase
- HMG-CoA synthase
- Malate synthase
|
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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Antigens: Autoantigens
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| Dehydrogenase |
- Branched-chain alpha-keto acid dehydrogenase complex
- Oxoglutarate dehydrogenase
- Pyruvate dehydrogenase
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| Transglutaminase |
- Epidermal transglutaminase
- Tissue transglutaminase
|
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| Nucleoporins |
- NUP35
- NUP37
- NUP43
- NUP50
- NUP54
- NUP62
- NUP85
- NUP88
- NUP93
- NUP98
- NUP107
- NUP133
- NUP153
- NUP155
- NUP160
- NUP188
- NUP210
- NUP205
- NUP214
|
|
| Other |
- Acetylcholine receptor
- Actin
- Apolipoprotein H
- Cardiolipin
- Centromere
- Filaggrin (Citrullinate)
- Gangliosides
- Sp100 nuclear antigen
- Thrombin
- Topoisomerase
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Index of the immune system
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| Description |
- Physiology
- cells
- autoantigens
- autoantibodies
- complement
- surface antigens
- IG receptors
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| Disease |
- Allergies
- Immunodeficiency
- Immunoproliferative immunoglobulin disorders
- Hypersensitivity and autoimmune disorders
- Neoplasms and cancer
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| Treatment |
- Procedures
- Drugs
- immunostimulants
- immunosuppressants
- monoclonal antibodies
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UpToDate Contents
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English Journal
- Very mild lamellar ichthyosis with compound heterozygous TGM1 mutations including the novel missense mutation p.Leu693Phe.
- Sugiura K, Suga Y, Akiyama M.SourceDepartment of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
- Journal of dermatological science.J Dermatol Sci.2013 Nov;72(2):197-9. doi: 10.1016/j.jdermsci.2013.06.013. Epub 2013 Jul 10.
- PMID 23895935
- Caffeic acid induces keratinocyte differentiation by activation of PPAR-α
- Kim B, Kim JE, Kim HS.SourceR&D Center of Skin Science and Cosmetics, Enprani Co., Ltd, Incheon, Korea.
- The Journal of pharmacy and pharmacology.J Pharm Pharmacol.2013 Oct 21. doi: 10.1111/jphp.12159. [Epub ahead of print]
- OBJECTIVES: Peroxisome proliferator-activated receptors (PPAR)-α plays an important role in epidermal differentiation and barrier recovery, and topical treatment with PPAR-α agonists restores epidermal homeostasis in essential fatty acid deficiency and permeability barrier in skin disruptions. The
- PMID 24138287
- Nonsyndromic types of ichthyoses - an update.
- Traupe H, Fischer J, Oji V.SourceDepartment of Dermatology, University of Münster, Germany.
- Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.J Dtsch Dermatol Ges.2013 Oct 11. doi: 10.1111/ddg.12229. [Epub ahead of print]
- Ichthyoses are genetically determined Mendelian disorders of cornification (MEDOC) that are characterized by universal scaling. Today we distinguish between non-syndromic and syndromic forms. Ichthyosis vulgaris is the most frequent type (prevalence 1:100) and is caused by autosomal semi-dominant fi
- PMID 24119255
Japanese Journal
- 微生物トランスグルタミナーゼの発見とアクティバ製剤の開発 (特集 食品化学新聞社創立50周年企画 : 食品加工技術のこれまでと今後) -- (食品加工技術の分岐点)
- 1P-082 一本鎖DNA 末端への効率的な酵素標識に向けた基礎検討(酵素学,酵素工学,一般講演)
- Effects of low molecular weight soybean peptide on mRNA and protein expression levels of differentiation markers in normal human epidermal keratinocytes
- 徳留 嘉寛,中村 恭介,橋本 フミ惠
- Bioscience, Biotechnology, and Biochemistry 78(6), 1018-1021, 2014-06
- … Low molecular weight soybean peptide (LSP) was applied to normal human epidermal keratinocytes, and the results showed a significant increase in the gene expression levels of involucrin, transglutaminase, and profilaggrin. …
- NAID 120005590300
Related Links
- What is TG? Regulatory Status Safety Celiac Disease & TG Environmental Impact & Benefits Communication News Contact Q & A for Transglutaminase More Selected Topics What is transglutaminase (TG)? Is TG safe? What is ...
- The official name of this gene is “transglutaminase 1.” TGM1 is the gene's official symbol. The TGM1 gene is also known by other names, listed below. Read more about gene names and symbols on the About page.
Related Pictures
★リンクテーブル★
[★]
- 英
- transglutaminase, TGase
- 同
- グルタミン転移酵素
- 関
- トランスグルタミナーゼ、周辺帯
トランスグルタミナーゼ1
- 英
- transglutaminase 1, tgase 1
臨床関連
- 葉状魚鱗癬
- 92kDa
- 817AA
- 有棘層上層～顆粒層
- 機能：ε-(γ-グルタミル)リジン結合を作る。周辺帯の形成に関わる
[★]
トランスグルタミナーゼ、グルタミン転移酵素