transforming growth factor beta receptor

• トランスフォーミング増殖因子β受容体、形質転換増殖因子β受容体

関

TGF-beta receptor、TGFBR

WordNet

1. to remain unmolested, undisturbed, or uninterrupted -- used only in infinitive form; "let her be"
2. work in a specific place, with a specific subject, or in a specific function; "He is a herpetologist"; "She is our resident philosopher" (同)follow
3. have life, be alive; "Our great leader is no more"; "My grandfather lived until the end of war" (同)live
4. be identical to; be someone or something; "The president of the company is John Smith"; "This is my house"
5. happen, occur, take place; "I lost my wallet; this was during the visit to my parents house"; "There were two hundred people at his funeral"; "There was a lot of noise in the kitchen"
6. have the quality of being; (copula, used with an adjective or a predicate noun); "John is rich"; "This is not a good answer"
7. occupy a certain position or area; be somewhere; "Where is my umbrella?" "The toolshed is in the back"; "What is behind this behavior?"
8. spend or use time; "I may be an hour"
9. cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
10. come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
11. become attached by or as if by the process of growth; "The tree trunks had grown together"
12. become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
13. cause to grow or develop; "He grows vegetables in his backyard"
14. increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
15. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
16. (pathology) an abnormal proliferation of tissue (as in a tumor)
17. a progression from simpler to more complex forms; "the growth of culture"
18. something grown or growing; "a growth of hair"
19. vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
20. be a contributing factor; "make things factor into a companys profitability"
21. any of the numbers (or symbols) that form a product when multiplied together
22. an independent variable in statistics
23. anything that contributes causally to a result; "a number of factors determined the outcome"
24. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
25. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
26. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
27. a concept whose truth can be proved; "scientific hypotheses are not facts"
28. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
29. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"

PrepTutorEJDIC

1. 《連結語として補語を伴なって…『である』,…だ,…です / 《位置・場所を表す語句を伴って》(…に)『ある』,いる(occupy a place or situation) / 〈物事が〉『存在する』,ある(exist);〈生物が〉生存する,生きている(live) / 行われる,起こる,発生する(take place, occur) / 存続する,そのままでいる(remain as before) / 《『be to』 do》 / …する予定である,…することになっている / …すべきだ / 《受動態の不定詞を伴って》…できる / 《命令》…するのだ / 《条件節に》…する意図がある / 《『if…were to』 do》…するとしたなら / 《『be』 do『ing』》《進行形》 / 《進行中の動作》…している,しつつある / 《近い未来》…しようとしている,するつもり / 《動作の反復》(いつも)…している / 《『be』+『他動詞の過去分詞』》《受動態》…される,されている / 《『be』+『自動詞の過去分詞』》《完了形》…した[状態にある]
2. 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
3. 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
4. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
5. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/07 23:27:29」(JST)

wiki en

[Wiki en表示]

transforming growth factor beta, receptor type I (activin A receptor type II-like kinase, 53kDa)
Identifiers
Symbol	TGFBR1
Entrez	7046
HUGO	11772
OMIM	190181
RefSeq	NM_004612
UniProt	P36897
Other data
Locus	Chr. 9 q22

transforming growth factor beta, receptor type II (70/80kDa)
Identifiers
Symbol	TGFBR2
Alt. symbols	MFS2
Entrez	7048
HUGO	11773
OMIM	190182
RefSeq	NM_001024847
UniProt	P37173
Other data
Locus	Chr. 3 p22

transforming growth factor beta, receptor type III
Identifiers
Symbol	TGFBR3
Entrez	7049
HUGO	11774
OMIM	600742
RefSeq	NM_003243
UniProt	Q03167
Other data
Locus	Chr. 1 p33-p32

TGFβ receptors are single pass serine/threonine kinase receptors. They exist in several different isoforms that can be homo- or heterodimeric. The number of characterized ligands in the TGFβ superfamily far exceeds the number of known receptors, suggesting the promiscuity that exists between the ligand and receptor interactions.

TGF (Transforming Growth Factor) are involved in paracrine signalling and can be found in many different tissue types, including brain, heart, kidney, liver, and testes. Over-expression of TGF can induce renal fibrosis, causing kidney disease, as well as diabetes, and ultimately end-stage renal disease (ESRD). Recent developments have found that, using certain types of protein antagonists against TGFβ receptors, can halt and in some cases reverse the effects of renal fibrosis.

Classification

Three TGF-β receptor types can be distinguished by their structural and functional properties. Receptor types I and II have similar ligand-binding affinities and can be distinguished from each other only by peptide mapping. Both receptor types I and II have a high affinity for TGF-β1 and low affinity for TGF-β2. TGF-β receptor type III has a high affinity for both TGF-β1 and -β2 and in addition TGF-β1.2.

Types

• TGF beta receptor 1
• TGF beta receptor 2
• TGF beta receptor 3

References

External links

• TGF-beta Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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English Journal

• Enhanced effect of β-tricalcium phosphate phase on neovascularization of porous calcium phosphate ceramics: In vitro and in vivo evidence.

• Chen Y1, Wang J1, Zhu XD2, Tang ZR1, Yang X1, Tan YF1, Fan YJ1, Zhang XD3.
• Acta biomaterialia.Acta Biomater.2015 Jan 1;11:435-48. doi: 10.1016/j.actbio.2014.09.028. Epub 2014 Sep 22.
• Neovascularization plays a key role in bone repair and regeneration. In the present study, four types of porous calcium phosphate (CaP) ceramics, namely hydroxyapatite (HA), biphasic calcium phosphates (BCP-1 and BCP-2) and β-tricalcium phosphate (β-TCP), with HA to β-TCP ratios of 100/0, 70/30,
• PMID 25246313

• Expression and significance of transforming growth factor-β receptor type II and DPC4/Smad4 in non-small cell lung cancer.

• Chen H1, Wang JW2, Liu LX2, Yan JD2, Ren SH2, Li Y2, Lu Z2.
• Experimental and therapeutic medicine.Exp Ther Med.2015 Jan;9(1):227-231. Epub 2014 Nov 12.
• The aim of the present study was to investigate the expression levels of transforming growth factor-β (TGF-β) receptor type II (TβRII) and DPC4/Smad4 in the TGF-β signaling pathway and the importance of these expression levels in non-small cell lung cancer (NSCLC). The mRNA and protein expressio
• PMID 25452807

• Myofiber-specific inhibition of TGFβ signaling protects skeletal muscle from injury and dystrophic disease in mice.

• Accornero F1, Kanisicak O1, Tjondrokoesoemo A1, Attia AC1, McNally EM2, Molkentin JD3.
• Human molecular genetics.Hum Mol Genet.2014 Dec 20;23(25):6903-15. doi: 10.1093/hmg/ddu413. Epub 2014 Aug 8.
• Muscular dystrophy (MD) is a disease characterized by skeletal muscle necrosis and the progressive accumulation of fibrotic tissue. While transforming growth factor (TGF)-β has emerged as central effector of MD and fibrotic disease, the cell types in diseased muscle that underlie TGFβ-dependent pa
• PMID 25106553

Japanese Journal

• Bone Morphogenetic Proteins Are Mediators of Luteolysis in the Human Corpus Luteum

• Endocrinology 156(4), 1494-1503, 2015-04
• NAID 120005611263

• O-9 蛋白尿惹起液性因子soluble urokinase receptor (suPAR)および間質障害に関連するTGF-βに対するLDLアフェレシス施行の影響(腎疾患(1),一般演題3,第35回日本アフェレシス学会学術大会)

• 日本アフェレシス学会雑誌 33(Supplement), 157, 2014-09-26
• NAID 110009874521

• VEGFR1 signaling facilitates diabetic skin wound healing in mice

• Microvascular Reviews and Communications 7(1), 28a-28a, 2014
• NAID 130004678497

Related Links

• TGF beta receptors - Wikipedia, the free encyclopedia

TGFβ receptors are single pass serine/threonine kinase receptors. They exist in several different isoforms that can be homo- or heterodimeric. The number of characterized ligands in the TGFβ superfamily far exceeds the number of known ...

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★リンクテーブル★

リンク元	「トランスフォーミング増殖因子β受容体」「形質転換増殖因子β受容体」「TGFBR」「TGF-beta receptor」
関連記事	「grow」「fact」「factor」「transforming」「growth」

「トランスフォーミング増殖因子β受容体」

　　[★]

英

transforming growth factor beta receptor、TGFBR

関

TGFβ受容体、形質転換増殖因子β受容体、TGF-β受容体

「形質転換増殖因子β受容体」

　　[★]

英

transforming growth factor beta receptor

関

トランスフォーミング増殖因子β受容体

「TGFBR」

　　[★]

• トランスフォーミング増殖因子β受容体

関

transforming growth factor beta receptor

「TGF-beta receptor」

　　[★]

• TGFβ受容体、TGFβレセプター

関

transforming growth factor beta receptor

「grow」

　　[★]

• v.

(過去: grew-過去分詞: grown)

• 成長する、生育する、伸びる

関

extend、growth、outgrow、outgrowth、stretch

　 　 　 　 　 　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「transforming」

　　[★]

• 形質転換、トランスフォーミング

関

transform、transformation、transgenic

「growth」

　　[★]

• n.

• 成長