WordNet

a gene that disposes normal cells to change into cancerous tumor cells (同)transforming_gene
(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
informal term for information; "give me the gen on your new line of computers"

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1. 急性骨髄性白血病の分子遺伝学 molecular genetics of acute myeloid leukemia
2. 膵外分泌癌の分子学的病因 molecular pathogenesis of exocrine pancreatic cancer
3. 大腸癌の分子遺伝学 molecular genetics of colorectal cancer
4. 不整脈原性右室心筋症の遺伝学および病因 genetics and pathogenesis of arrhythmogenic right ventricular cardiomyopathy
5. 鎌状細胞貧血における臨床的ばらつき clinical variability in sickle cell anemia

Choi SI1, Kim EK2.
Experimental eye research.Exp Eye Res.2016 Mar;144:14-21. doi: 10.1016/j.exer.2015.09.008. Epub 2015 Sep 18.
Autophagy is a lysosomal degradative process that is essential for cellular homeostasis and metabolic stress adaptation. Defective autophagy is involved in the pathogenesis of many diseases including granular corneal dystrophy type 2 (GCD2). GCD2 is an autosomal dominant disorder caused by substitut
PMID 26386150

Liu Y1, Han N2, Zhou S1, Zhou R1, Yuan X2, Xu H2, Zhang C1, Yin T1, Wu K2.
International journal of cancer. Journal international du cancer.Int J Cancer.2016 Mar 1;138(5):1067-75. doi: 10.1002/ijc.29560. Epub 2015 Jun 12.
The functional abnormality of developmental genes is a common phenomenon in cancer initiation and progression. The retinal determination gene network (RDGN) is a key signal in Drosophila eye specification, and this conservative pathway is also required for the development of multiple organs in mamma
PMID 26096807

Biological relevance of Hsp90-binding immunophilins in cancer development and treatment.

Mazaira GI1, Camisay MF1, De Leo S1, Erlejman AG1, Galigniana MD1,2.
International journal of cancer. Journal international du cancer.Int J Cancer.2016 Feb 15;138(4):797-808. doi: 10.1002/ijc.29509. Epub 2015 Mar 24.
Immunophilins are a family of intracellular receptors for immunosuppressive drugs. Those immunophilins that are related to immunosuppression are the smallest proteins of the family, i.e., FKBP12 and CyPA, whereas the other members of the family have higher molecular weight because the show additiona
PMID 25754838

Protein inhibitor of activated STAT, PIASy regulates α-smooth muscle actin expression by interacting with E12 in mesangial cells.

Torikoshi Kazuo,Abe Hideharu,Matsubara Takeshi,Hirano Takahiro,Ohshima Takayuki,Murakami Taichi,Araki Makoto,Mima Akira,Iehara Noriyuki,Fukatsu Atsushi,Kita Toru,Arai Hidenori,Doi Toshio
PloS one 7(7), 2012-07-19
… Furthermore, transforming growth factor-β (TGF-β) treatment induced expression of both PIASy and E12, consistent with α-SMA expression. … These results suggest that TGF-β up-regulates PIASy expression in MCs to down-regulateα-SMA gene transcription by the interaction with E12. …
NAID 120004770223

Pituitary Tumor-Transforming Gene 1 Enhances Proliferation and Suppresses Early Differentiation of Keratinocytes

Ishitsuka Yosuke,Kawachi Yasuhiro,Taguchi Shijima,Maruyama Hiroshi,Fujisawa Yasuhiro,Furuta Junichi,Nakamura Yasuhiro,Otsuka Fujio,石塚洋典,川内康弘,藤澤康弘,古田淳一,中村泰大,大塚藤男
Journal of investigative dermatology 132(7), 1775-1784, 2012-07-00
… The cell cycle regulation is dependent on the interactions among a number of cell cycle regulatory molecules, including the pituitary tumor-transforming gene 1 (PTTG1), also known as securin, a regulator of sister chromatid separation and transition from metaphase to anaphase. …
NAID 120005246585

Role of ComEA in DNA uptake during transformation of competent Bacillus subtilis(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)

Takeno Masaomi,Taguchi Hisataka,Akamatsu Takashi
Journal of bioscience and bioengineering 113(6), 689-693, 2012-06-00
… Taken together, the results indicate that ComEA plays an important role in the transfer of transforming DNA into the DNA channel and in controlling the rate of DNA uptake. …
NAID 110009470586