transcriptional activator

WordNet

1. (genetics) the organic process whereby the DNA sequence in a gene is copied into mRNA; the process whereby a base sequence of messenger RNA is synthesized on a template of complementary DNA
2. a sound or television recording (e.g., from a broadcast to a tape recording)
3. something written, especially copied from one medium to another, as a typewritten version of dictation (同)written text
4. (biology) any agency bringing about activation; a molecule that increases the activity of an enzyme or a protein that increases the production of a gene product in DNA transcription

PrepTutorEJDIC

1. 〈U〉(…を)書き写す(書き直す)こと,(…の)転写,謄写《+of+名》 / 〈C〉写し(書き直し)[たもの] / 〈U〉〈C〉編曲[されたもの] / 〈U〉〈C〉(ラジオ・テレビの)録音(録画)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/20 01:55:48」(JST)

wiki en

[Wiki en表示]

A transcriptional activator is a protein (transcription factor) that increases gene transcription of a gene or set of genes. Most activators are DNA-binding proteins that bind to enhancers or promoter-proximal elements.

Most activators function by binding sequence-specifically to a DNA site located in or near a promoter and making protein–protein interactions with the general transcription machinery (RNA polymerase and general transcription factors), thereby facilitating the binding of the general transcription machinery to the promoter. The DNA site bound by the activator is referred to as an "activator site." The part of the activator that makes protein–protein interactions with the general transcription machinery is referred to as an "activating region." The part of the general transcription machinery that makes protein–protein interactions with the activator is referred to as an "activation target."

Example

The catabolite activator protein (CAP; also known as cAMP receptor protein, CRP) activates transcription at the lac operon of the bacterium Escherichia coli. Cyclic adenosine monophosphate (cAMP) is produced during glucose starvation, binds to CAP, causes a conformational change that allows CAP to bind to a DNA site located adjacent to the lac promoter. CAP then makes a direct protein–protein interaction with RNA polymerase that recruits RNA polymerase to the lac promoter.

lac operon in detail

See also

• Glossary of gene expression terms
• Operon
• Promoter (biology)
• Regulation of gene expression
• Repressor
• Transcription factor

References

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 複合免疫不全 combined immunodeficiencies
• 2. 赤血球産生調節 regulation of erythropoiesis
• 3. 2型糖尿病の病因 pathogenesis of type 2 diabetes mellitus
• 4. 骨髄造血の制御 regulation of myelopoiesis
• 5. 喘息における吸入ステロイドの分子学的影響 molecular effects of inhaled glucocorticoid therapy in asthma

English Journal

• Myostatin gene mutated mice induced with tale nucleases.

• Zhou F1, Sun R, Chen H, Fei J, Lu D.
• Animal biotechnology.Anim Biotechnol.2015 Jul 3;26(3):169-79. doi: 10.1080/10495398.2014.913598.
• Myostain gene (MSTN) is expressed primarily in skeletal muscle, and negatively regulates skeletal muscle mass; it has been suggested that mice with MSTN inhibition have reduced adiposity and improved insulin sensitivity. Therefore, it is important to establish a fast and effective gene editing metho
• PMID 25695746

• Analysis of mechanical ventilation and lipopolysaccharide‑induced acute lung injury using DNA microarray analysis.

• Chen Y1, Zhou X1, Rong L2.
• Molecular medicine reports.Mol Med Rep.2015 Jun;11(6):4239-45. doi: 10.3892/mmr.2015.3335. Epub 2015 Feb 11.
• Gene expression profiles of samples taken from patients with acute lung injury (ALI) induced by mechanical ventilation (MV) and lipopolysaccharide (LPS) were analyzed in order to identify key genes, and explore the underlying mechanisms. The GSE2411 microarray data set was downloaded from the Gene E
• PMID 25672411

Japanese Journal

• Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation.

• PLoS genetics 12(1), 2016-01-28
• NAID 120005698038

• Crucial Role of the Aryl Hydrocarbon Receptor (AhR) in Indoxyl Sulfate-Induced Vascular Inflammation

• Journal of Atherosclerosis and Thrombosis advpub(0), 2016
• NAID 130005125675

Related Pictures

---

★リンクテーブル★

リンク元	「転写活性化タンパク」「転写活性化因子」
関連記事	「activator」「transcriptional」

「転写活性化タンパク」

　　[★]

英

[[]]

同

transcriptional activator

関

[[]]

同

transcriptional activator

「転写活性化因子」

　　[★]

英

transcriptional activator

「activator」

　　[★]

• n.

• 活性化因子、活性化薬、活性化剤、賦活薬、活性化物質、アクチベーター、アクティベーター

　

「transcriptional」

　　[★]

• 転写性の

関

transcriptionally