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WordNet

(genetics) the organic process whereby the DNA sequence in a gene is copied into mRNA; the process whereby a base sequence of messenger RNA is synthesized on a template of complementary DNA
a sound or television recording (e.g., from a broadcast to a tape recording)
something written, especially copied from one medium to another, as a typewritten version of dictation (同)written text
occupy an intermediate or middle position or form a connecting link or stage between two others; "mediate between the old and the new"
acting through or dependent on an intervening agency; "the disease spread by mediate as well as direct contact"
addition of extra material or illustration or clarifying detail; "a few remarks added in amplification and defense"; "an elaboration of the sketch followed" (同)elaboration
the amount of increase in signal power or voltage or current expressed as the ratio of output to input (同)gain
(electronics) the act of increasing voltage or power or current
acting or brought about through an intervening agency; "the mediated settlement brought satisfaction to both sides"

PrepTutorEJDIC

〈U〉(…を)書き写す(書き直す)こと,(…の)転写,謄写《+of+名》 / 〈C〉写し(書き直し)[たもの] / 〈U〉〈C〉編曲[されたもの] / 〈U〉〈C〉(ラジオ・テレビの)録音(録画)
〈紛争・相違点など〉‘を'調停する,仲裁する / 〈妥協・和解・同意など〉‘を'仲裁して成立させる / (両者の)調停をする《+『between』+『名』》 / 仲介者(媒介物)を通じての,間接の
拡大,拡張,増大 / (電気の)増幅;(レンズの)倍率

UpToDate Contents

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1. 淋菌感染症の診断 diagnosis of gonococcal infections
2. トリコモナス trichomoniasis
3. 女性における性器クラミジア・トラコマチス感染症 genital chlamydia trachomatis infections in women
4. 新生児におけるChlamydia trachomatis感染症 chlamydia trachomatis infections in the newborn
5. クラミジア・トラコマティス感染症の臨床症状および診断 clinical manifestations and diagnosis of chlamydia trachomatis infections

English Journal

Association of Sly with sex-linked gene amplification during mouse evolution: a side effect of genomic conflict in spermatids?

Ellis PJ, Bacon J, Affara NA.AbstractIn common with other mammalian sex chromosomes, the mouse sex chromosomes are enriched for genes with male-specific function such as testis genes. However, in mouse there has been an unprecedented expansion of ampliconic sequence containing spermatid-expressed genes. We show via a phylogenetic analysis of gene amplification on the mouse sex chromosomes that multiple families of sex-linked spermatid-expressed genes are highly amplified in Mus musculus subspecies and in two further species from the Palaearctic clade of mouse species. Ampliconic X-linked genes expressed in other cell types showed a different evolutionary trajectory, without the distinctive simultaneous amplification seen in spermatid-expressed genes. The Palaearctic gene amplification occurred concurrently with the appearance of Sly, a Yq-linked regulator of post-meiotic sex chromatin (PMSC) which acts to repress sex chromosome transcription in spermatids. Despite the gene amplification, there was comparatively little effect on transcript abundance, suggesting that the genes in question became amplified in order to overcome Sly-mediated transcriptional repression and maintain steady expression levels in spermatids. Together with the known sex-ratio effects of Yq/Sly deficiency, our results suggest that Sly is involved in a genomic conflict with one or more X-linked sex-ratio distorter genes. The recent evolution of the novel PMSC regulator Sly in mouse lineages has significant implications for the use of mouse-model systems in investigating sex chromosome dynamics in spermatids.
Human molecular genetics.Hum Mol Genet.2011 Aug 1;20(15):3010-21. Epub 2011 May 6.
In common with other mammalian sex chromosomes, the mouse sex chromosomes are enriched for genes with male-specific function such as testis genes. However, in mouse there has been an unprecedented expansion of ampliconic sequence containing spermatid-expressed genes. We show via a phylogenetic analy
PMID 21551453

Visual detection of human enterovirus 71 subgenotype C4 and Coxsackievirus A16 by reverse transcription loop-mediated isothermal amplification with the hydroxynaphthol blue dye.

Nie K, Zhang Y, Luo L, Yang MJ, Hu XM, Wang M, Zhu SL, Han F, Xu WB, Ma XJ.SourceState Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changbai Rd 155, Changping district, Beijing 102206, China.
Journal of virological methods.J Virol Methods.2011 Aug;175(2):283-6. Epub 2011 May 19.
A sensitive reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay was developed for rapid visual detection of human enterovirus 71 subgenotype C4 (EV71-C4) and Coxsackievirus A16 (CVA16) infection, respectively. The reaction was performed in one step in a single tube at 65°C
PMID 21621554