- 関
- transcytosis
WordNet
- move something or somebody around; usually over long distances
- an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
- move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
- transport commercially (同)send, ship
PrepTutorEJDIC
- (ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/08/19 14:47:01」(JST)
[Wiki en表示]
Transcellular transport involves the transportation of solutes by a cell through a cell. One classic example is the movement of glucose from the intestinal lumen to extracellular fluid by epithelial cells.
Epithelial cells use primary and secondary active transport, often in conjunction with passive diffusion through ion channels, to produce transcellular transport across epithelial tissues. This transport can either be absorption, transport from lumen (apical membrane surface) to blood, or secretion, transport from blood (basolateral membrane surface) to lumen.
The transcellular pathway of transport is important in the intestinal absorption of drug molecules, the other being the paracellular pathway. The transcellular pathway of transport include transcellular diffusion, active carrier mediated transportation, and transcytosis. The transcelluar diffusion simply involves the movement of solutes based on a diffusion gradient moving from an area of high concentration to an area of low concentration, however, the cell membrane is a hydrophobic environment and will not allow the passive diffusion of charged, hydrophilic, or zwitterion molecules. Active transport involves the use of energy to transport specific substrates across barriers, even against the concentration gradient. Macromolecules can sometimes be transported through transcytosis.
In contrast, paracellular transport is the transfer of substances across an epithelium by passing through an intercellular space between the cells.
- 1. It differs from transcellular transport, where the substances travel through the cell passing through both the apical membrane and basolateral membrane
- 2. Renal physiology. Transcellular transport is more likely to involve energy expenditure than paracellular transpoort.
- 3. Capillaries of the blood–brain barrier have only transcellular transport in contrast with normal capillaries which have both transcellular and paracellular transport.
References[edit source | edit]
UpToDate Contents
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English Journal
- Non-invasive approaches for drug delivery to the brain based on the receptor mediated transport.
- Fang F1, Zou D1, Wang W1, Yin Y1, Yin T1, Hao S1, Wang B1, Wang G1, Wang Y2.
- Materials science & engineering. C, Materials for biological applications.Mater Sci Eng C Mater Biol Appl.2017 Jul 1;76:1316-1327. doi: 10.1016/j.msec.2017.02.056. Epub 2017 Feb 24.
- PMID 28482500
- Calibrated flux measurements reveal a nanostructure-stimulated transcytotic pathway.
- Stewart T1, Koval WT2, Molina SA2, Bock SM3, Lillard JW Jr4, Ross RF3, Desai TA5, Koval M6.
- Experimental cell research.Exp Cell Res.2017 Jun 15;355(2):153-161. doi: 10.1016/j.yexcr.2017.03.065. Epub 2017 Apr 5.
- PMID 28390677
- Botulinum neurotoxin type A-cleaved SNAP25 is confined to primary motor neurons and localized on the plasma membrane following intramuscular toxin injection.
- Cai BB1, Francis J1, Brin MF2, Broide RS3.
- Neuroscience.Neuroscience.2017 Jun 3;352:155-169. doi: 10.1016/j.neuroscience.2017.03.049. Epub 2017 Apr 5.
- PMID 28389376
Japanese Journal
- <i>In Vitro</i> P-Glycoprotein-Mediated Transport of Tadalafil: A Comparison with Sildenafil
- Paracellular Transport of Sulforaphane across Caco-2 Cell Monolayers
- Current concepts in perinatal mineral metabolism
Related Links
- trans·cel·lu·lar trans·port solute movement across an epithelial cell layer through the cells. Compare: paracellular transport. transcellular transport, transport of molecules through the cells of an epithelial cell layer. trans·cel·lu·lar trans ...
- The definition information for transcellular transport is provided by Stedman's. You can search our medical dictionary here. Stedman's, part of Lippincott Williams & Wilkins, provides a comprehensive line of health-science publications ...
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- 英
- transcytosis、transcellular transport
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- 関
- bring、carriage、carry、convey、delivery、ship、traffic、trafficking、transportation