tranexamic acid

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/11/20 23:21:26」(JST)

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  • Differential effects of aprotinin and tranexamic acid on outcomes and cytokine profiles in neonates undergoing cardiac surgery.
  • Graham EM, Atz AM, Gillis J, Desantis SM, Haney AL, Deardorff RL, Uber WE, Reeves ST, McGowan FX Jr, Bradley SM, Spinale FG.SourceDivision of Cardiology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC.
  • The Journal of thoracic and cardiovascular surgery.J Thorac Cardiovasc Surg.2012 May;143(5):1069-76. Epub 2011 Nov 9.
  • OBJECTIVE: Factors contributing to postoperative complications include blood loss and a heightened inflammatory response. The objective of this study was to test the hypothesis that aprotinin would decrease perioperative blood product use, reduce biomarkers of inflammation, and result in improved cl
  • PMID 22075061
  • A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass (CONSERV-2 Trial).
  • Bokesch PM, Szabo G, Wojdyga R, Grocott HP, Smith PK, Mazer CD, Vetticaden S, Wheeler A, Levy JH.SourceCubist Pharmaceuticals, Inc, Lexington, Mass; St Elizabeth's Hospital, Tufts University School of Medicine, Boston, Mass.
  • The Journal of thoracic and cardiovascular surgery.J Thorac Cardiovasc Surg.2012 May;143(5):1022-9. Epub 2011 Jul 2.
  • OBJECTIVE: Ecallantide is a recombinant peptide in the same class as aprotinin that inhibits plasma kallikrein, a major component of the contact coagulation and inflammatory cascades. Therefore, ecallantide was expected to reduce blood loss associated with cardiac surgery requiring cardiopulmonary b
  • PMID 21724197


  • THAの入室時カルバゾクロムスルホン酸ナトリウムとトラネキサム酸静注の術中術後出血量に及ぼす影響
  • 松葉 友幸,小林 千益,百瀬 敏充,中川 浩之,田中 厚誌,安田 岳
  • 中部日本整形外科災害外科学会雑誌. 中部日本整形外科災害外科学会抄録 54(5), 1021-1022, 2011-09-01
  • NAID 10029799629
  • 人工心肺使用開心術後における痙攣発作についての検討
  • 長峰 大輔,平井 晃一,金内 昭憲,天田 望,福本 恵,秋山 知宏,平本 明徳,角野 聡,斉藤 祐二,高瀬 真一
  • 体外循環技術 = The journal of extra-corporeal technology 38(3), 436-438, 2011-09-01
  • NAID 10029578593



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tranexamic acid
acidum tranexamicum
trans-4-aminomethylcyclohexane-1-carboxylic acid, t-AMCHA, 4-(aminomethyl)cyclohexane-carboxylic acid, EACA


  • フィブリンのリシン残基に似た構造


  • フィブリンのリシン残基に似ているため、プラスミンがフィブリンではなくε-アミノカプロン酸に結合する。このためフィブリンの分解が抑制され、結果として線溶系が抑制される。



WordNet   license wordnet

「street name for lysergic acid diethylamide」
back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen

WordNet   license wordnet

「any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt」

WordNet   license wordnet

「having the characteristics of an acid; "an acid reaction"」

PrepTutorEJDIC   license prepejdic

「酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD」