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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/06/22 20:05:33」(JST)

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  • Synthesis of Tolmetin Hydrazide-Hydrazones and Discovery of a Potent Apoptosis Inducer in Colon Cancer Cells.
  • Küçükgüzel ŞG1, Koç D1, Çıkla-Süzgün P1, Özsavcı D2, Bingöl-Özakpınar Ö2, Mega-Tiber P3, Orun O3, Erzincan P4, Sağ-Erdem S4, Şahin F5.
  • Archiv der Pharmazie.Arch Pharm (Weinheim).2015 Oct;348(10):730-42. doi: 10.1002/ardp.201500178. Epub 2015 Aug 19.
  • Tolmetin hydrazide and a novel series of tolmetin hydrazide-hydrazones 4a-l were synthesized in this study. The structures of the new compounds were determined by spectral (FT-IR, (1)H NMR) methods. N'-[(2,6-Dichlorophenyl)methylidene]-2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetohydrazide (4
  • PMID 26287512
  • Significantly Different Covalent Binding of Oxidative Metabolites, Acyl Glucuronides, and S-Acyl CoA Conjugates Formed from Xenobiotic Carboxylic Acids in Human Liver Microsomes.
  • Darnell M, Breitholtz K, Isin EM, Jurva U, Weidolf L.
  • Chemical research in toxicology.Chem Res Toxicol.2015 May 18;28(5):886-96. doi: 10.1021/tx500514z. Epub 2015 Apr 8.
  • Xenobiotic carboxylic acids may be metabolized to oxidative metabolites, acyl glucuronides, and/or S-acyl-CoA thioesters (CoA conjugates) in vitro, e.g., in hepatocytes, and in vivo. These metabolites can potentially be reactive species and bind covalently to tissue proteins and are generally consid
  • PMID 25803559
  • The influence of API concentration on the roller compaction process: modeling and prediction of the post compacted ribbon, granule and tablet properties using multivariate data analysis.
  • Boersen N1, Carvajal MT, Morris KR, Peck GE, Pinal R.
  • Drug development and industrial pharmacy.Drug Dev Ind Pharm.2015;41(9):1470-8. doi: 10.3109/03639045.2014.958754. Epub 2015 Jul 21.
  • OBJECTIVE: While previous research has demonstrated roller compaction operating parameters strongly influence the properties of the final product, a greater emphasis might be placed on the raw material attributes of the formulation. There were two main objectives to this study. First, to assess the
  • PMID 25212638


  • アシルグルクロニドによる細胞毒性のメカニズム解析
  • 宮下 泰志,深見 達基,中島 美紀,横井 毅
  • 日本毒性学会学術年会 40.1(0), 2003157, 2013
  • … 本研究ではAGを生成する薬物としてdiclofenac (DCF),ibuprofen (Ibu),naproxen (Nap),probenecid (Pro) およびtolmetin (Tol) を用いて,AGにより生じる細胞毒性を,炎症性因子を指標として評価し,その機序を解明することを目的とした。 …
  • NAID 130004676750
  • 非ステロイド性抗炎症薬(non-steroidal anti-inflammatory drugs)の戦略的用法を目指して: ペルオキシダーゼとの反応性を基にした非ステロイド性抗炎症薬の分類
  • 三浦 俊明
  • YAKUGAKU ZASSHI 133(6), 681-689, 2013
  • … Class 3 includes aspirin, nimesulide, tolmetin, and arylpropionic acid derivatives, including ibuprofen and the coxibs such as celecoxib and rofecoxib, which are not substrates for HRP or PGHS peroxidase. …
  • NAID 130003361963
  • A Simple Method to Evaluate Reactivity of Acylglucuronides Optimized for Early Stage Drug Discovery
  • Jinno Norimasa,Ohashi Shigeki,Tagashira Mizuka [他],Kohira Terutomo,Yamada Shizuo
  • Biological and Pharmaceutical Bulletin 36(9), 1509-1513, 2013
  • … We evaluated the half-lives of 10 drugs: 3 safe drugs (telmisartan, gemfibrozil and flufenamic acid) and 7 withdrawn or warning drugs (zomepirac, diclofenac, furosemide, ibuprofen, S-naproxen, probenecid and tolmetin). …
  • NAID 130003361534




拡張検索tolmetin sodium



トルメチンナトリウム tolmetin sodium
  • 酸性非ステロイド性抗炎症薬

tolmetin sodium」

  [★] トルメチントルメチンナトリウム