WordNet

street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"

PrepTutorEJDIC

酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/11 03:38:53」(JST)

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Tolfenamic acid (TA) is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine.

Other possible uses

A study concludes, "TA was found significantly better than placebo in the subjective evaluation of drug efficacy (p<0.001) and in reducing the reported hangover symptoms in general (p < 0.01). In the TA group, significantly lower symptom scores were obtained for headache (p<0.01), and for nausea, vomiting, irritation, tremor, thirst and dryness of mouth (all p < 0.05)."^[1]

Commercial names

Commercial names for tolfenamic acid include Clotam Rapid and Tufnil for use in humans and Tolfedine for veterinary use in cats and dogs. This drug should not be confused with Tolmetin.

References

^ ^a ^b Kim Vilbour Andersen, Sine Larsen, Børge Alhede, Niels Gelting and Ole Buchardt (1989). = P29890001443 "Characterization of two polymorphic forms of tolfenamic acid, N-(2-methyl-3-chlorophenyl)anthranilic acid: their crystal structures and relative stabilities". J. Chem. Soc., Perkin Trans. 2 (10): 1443–1447. doi:10.1039/P29890001443.

External links

Tolfenamic acid information (Diseases Database)

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UpToDate Contents

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1. 尿酸のバランス uric acid balance
2. 出産時の臍帯血酸塩基分析 umbilical cord blood acid base analysis at delivery
3. 妊娠中の葉酸補充 folic acid supplementation in pregnancy
4. ポルフィリン症：概要 porphyrias an overview
5. 疾患予防におけるビタミン補給 vitamin supplementation in disease prevention

English Journal

Small molecule tolfenamic acid inhibits PC-3 cell proliferation and invasion in vitro, and tumor growth in orthotopic mouse model for prostate cancer.

Sankpal UT, Abdelrahim M, Connelly SF, Lee CM, Madero-Visbal R, Colon J, Smith J, Safe S, Maliakal P, Basha R.SourceCancer Research Institute, MD Anderson Cancer Center Orlando, Orlando, Florida.
The Prostate.Prostate.2012 Nov;72(15):1648-58. doi: 10.1002/pros.22518. Epub 2012 Apr 2.
BACKGROUND: Specificity protein (Sp) transcription factors are implicated in critical cellular and molecular processes associated with cancer that impact tumor growth and metastasis. The non-steroidal anti-inflammatory drug, tolfenamic acid (TA) is known to inhibit Sp proteins in some human cancer c
PMID 22473873

Raman and IR spectroscopic studies of fenamates - Conformational differences in polymorphs of flufenamic acid, mefenamic acid and tolfenamic acid.

Jabeen S, Dines TJ, Leharne SA, Chowdhry BZ.SourceSchool of Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent ME4 4TB, UK.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2012 Oct;96:972-85. doi: 10.1016/j.saa.2012.07.129. Epub 2012 Aug 10.
Solid-state Raman and IR spectra of two polymorphic forms of each of three fenamates (flufenamic acid, mefenamic acid and tolfenamic acid) display subtle but highly reproducible differences. Many of these spectral differences can be ascribed to different conformations of these molecules, involving t
PMID 22954807

Japanese Journal

Effect of N-Phenylanthranilic Acid Scaffold Nonsteroidal Anti-inflammatory Drugs on the Mitochondrial Permeability Transition

Biological and Pharmaceutical Bulletin 39(2), 278-284, 2016
NAID 130005122365

Apoptotic effect of tolfenamic acid on MDA-MB-231 breast cancer cells and xenograft tumors

Journal of Clinical Biochemistry and Nutrition 53(1), 21-26, 2013
NAID 130004879335

9,10-Phenanthrenequinone Induces Monocytic Differentiation of U937 Cells through Regulating Expression of Aldo-Keto Reductase 1C3

Biological and Pharmaceutical Bulletin 35(9), 1598-1602, 2012
NAID 130001872073

「トルフェナム酸」

Tolfenamic acid
Systematic (IUPAC) name
	2-[(3-chloro-2-methylphenyl)amino]benzoic acid)
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	Prescription Only (S4) (AU)
Routes	oral
Identifiers
CAS number	13710-19-5
ATC code	M01AG02
PubChem	CID 610479
ChemSpider	530683
UNII	3G943U18KM
KEGG	D01183
ChEBI	CHEBI:32243
ChEMBL	CHEMBL121626
Chemical data
Formula	C14H12ClNO2
Mol. mass	261.707 g/mol
	SMILES Clc2cccc(Nc1ccccc1C(=O)O)c2C;
	InChI InChI=1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18) ; Key:YEZNLOUZAIOMLT-UHFFFAOYSA-N ;
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　　[★]

英: tolfenamic acid
商: クロタム

フェナム酸系非ステロイド性抗炎症薬

[Andersen-1] Kim Vilbour Andersen, Sine Larsen, Børge Alhede, Niels Gelting and Ole Buchardt (1989). = P29890001443 "Characterization of two polymorphic forms of tolfenamic acid, N-(2-methyl-3-chlorophenyl)anthranilic acid: their crystal structures and relative stabilities". J. Chem. Soc., Perkin Trans. 2 (10): 1443–1447. doi:10.1039/P29890001443.

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案内

tolfenamic acid