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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/07/29 06:25:01」(JST)

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  • Innovative mechanisms of action for pharmaceutical cognitive enhancement: A systematic review.
  • Fond G1, Micoulaud-Franchi JA2, Brunel L3, Macgregor A4, Miot S5, Lopez R6, Richieri R7, Abbar M8, Lancon C2, Repantis D9.
  • Psychiatry research.Psychiatry Res.2015 Sep 30;229(1-2):12-20. doi: 10.1016/j.psychres.2015.07.006. Epub 2015 Jul 8.
  • Pharmacological cognitive enhancement refers to improvement in cognitive functions after drug use in healthy individuals. This popular topic attracts attention both from the general public and the scientific community. The objective was to explore innovative mechanisms of psychostimulant's action, w
  • PMID 26187342
  • Salvianolic acid B as a substrate and weak catechol-O-methyltransferase inhibitor in rats.
  • Qi Q1, Cao L, Li F, Wang H, Liu H, Hao H, Hao K.
  • Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2015 Sep;45(9):820-7. doi: 10.3109/00498254.2015.1017753. Epub 2015 Jun 12.
  • 1. The aim of this study was to investigate the biotransformation of salvianolic acid B (SAB) by catechol-O-methyltransferase (COMT) and its interaction with levodopa (l-DOPA) methylation in rats. 2. The enzyme kinetics of SAB were studied after incubation with rat COMT. The in vivo SAB and 3-mo
  • PMID 25869243
  • Optimization and pharmacological validation of a set-shifting procedure for assessing executive function in rats.
  • Troudet R1, Detrait E1, Hanon E1, Lamberty Y2.
  • Journal of neuroscience methods.J Neurosci Methods.2015 Aug 19. pii: S0165-0270(15)00303-9. doi: 10.1016/j.jneumeth.2015.08.012. [Epub ahead of print]
  • BACKGROUND: Set-shifting tests represent a reliable paradigm to assess executive functions in humans and animals. In the rat, set-shifting in a cross-maze is a recognized method. In this test, rats must learn an egocentric rule to locate food reinforcement. Once acquired, a second rule, based on vis
  • PMID 26296285


  • Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and D-amphetamine, but unaffected by the COMT inhibitor tolcapone
  • Neuroscience research : the official journal of the Japan Neuroscience Society 69(1), 41-50, 2011-01-01
  • NAID 10028190089
  • Identification of metabolite profiles of the catechol-O-methyl transferase inhibitor tolcapone in rat urine using LC/MS-based metabonomics analysis
  • SUN Jinchun,VON TUNGELN Linda S.,HINES Wade,BEGER Richard D.
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 877(24), 2557-2565, 2009-08-15
  • NAID 10028022264
  • 薬物療法 主な治療薬の種類と特徴 COMT阻害薬--概要,薬理作用,用法・用量,有用性,副作用とその対策 (パーキンソン病--基礎・臨床研究のアップデート) -- (治療)


Do not stop using tolcapone suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using tolcapone. You may have increased sexual urges, unusual urges to ...
Clinical and research information on drug-induced liver injury. ... Case 1. Acute liver failure attributed to tolcapone. [Modified from: Spahr L, Rubbia-Brandt L, Burkhard PR, Assal F, Hadengue A. Tolcapone-related fulminant hepatitis ...


comparison of Tolcapone and EntacaponeTasmar Tasmar (tolcapone) 100 mgLe médicament tolcapone (Tasmar) rend Tolcapone Chemical StructureLow Dopamine in Frontal Cortex Blamed For Tasmar - patient information, description